The Influence of Menthol in Ethanol Extract of Meniran Gel (Phyllanthus niruri L.) as a Hair Growth Promoter in Male Wistar Rats

https://doi.org/10.22146/mot.37303

Sri Luliana(1), Rise Desnita(2), Utia Mufliha(3*)

(1) Department of Pharmacy, Faculty of Medicine, Tanjungpura University, Pontianak, Kalimantan Barat
(2) Department of Pharmacy, Faculty of Medicine, Tanjungpura University, Pontianak, Kalimantan Barat
(3) Department of Pharmacy, Faculty of Medicine, Tanjungpura University, Pontianak, Kalimantan Barat
(*) Corresponding Author

Abstract


Phyllanthus niruri L. is known to promote hair growth. Menthol is one of the enhancers which promotes drug penetration into the skin. The aim of this research is to determine the potential of menthol in P. niruri Ethanol Extracts gel preparation as a hair growth promoter. The test animals were randomized into 4 groups: normal group, negative control (gel without extract and menthol), E1 group (Ethanol Extracts of P. niruri 5% gel without menthol) and E2 group (Ethanol Extracts of P. niruri 5% gel with menthol). Hair growth activity test was conducted by applying the gel on the rats’ back, and hair length was measured on the 7th, 14th and 21st days, while the hair was weighed on the 21st day. The results showed that the E2 group had an average hair length and hair weight of 12.45±3.457 mm and hair weight of 28.53±7.681 mg, greater than the E1 group of 10.67±2.455 mm and 19.87±9.552 mg respectively. Based on these results, it can be concluded that adding menthol in P. niruri Ethanol Extract gel preparation can influence hair growth and thickness.

Keywords


Ekstrak meniran; Gel; Enhancer; Aktivitas pertumbuhan rambut

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References

Adeneye, A.A., 2012. The leaf and seed aqueous extract of Phyllanthus amarus improves insulin resistance diabetes in experimental animal studies. Journal of Ethnopharmacology, 144(3), pp.705–11.

Aldi, Y., Rasyadi, Y. & Handayani, D., 2014. Immunomodulatory Activity of Meniran Extracts (Phyllanthus niruri Linn.) on Broiler Chickens. Jurnal Sains Farmasi & Klinis, 1(1), pp.20–26.

Bagalkotkar, G. et al., 2006. Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review. The Journal of pharmacy and pharmacology, 58, pp.1559–1570.

Da’i, M. et al., 2016. Antioxidant activity of Phyllanthus niruri L . herbs : in vitro and in vivo models and isolation of active compound. Nasional Journal of Physiology, Pharmacy and Pharmacology, 6(1), pp.32–38.

Darwis, D., 2008, ‘Uji praklinis pembalut luka hidrogel berbasis PVP steril iradiasi menggunakan tikus putih : Evaluasi iritasi dan sensitisasi’, Jurnal Ilmiah Aplikasi Isotop dan Radiasi, 4(1): pp 51-59.

Departemen Kesehatan Republik Indonesia, 2008, Farmakope herbal Indonesia, Edisi 1, Jakarta, Departemen Kesehatan Republik Indonesia, pp. 100-102.

Edityaningrum, C.A. & Heni, R., 2015, ‘Peningkatan stabilitas kurkumin melalui pembentukan kompleks kurkumin-b-siklodekstrin nanopartikel dalam bentuk gel’, Pharmaciana, 5(1), pp. 53–60.

Garg, A., Deepika, A., Sanjay, G. & Anil, K.S., 2002, ‘Spreading of semisolid formulations’, Pharmaceutical technology, pp. 84–105.

Hiipakka, R.A., Han, Z.Z., Wei, D., Qing, D. & Shutsung, L., 2002, ‘Structure –activity relationships for inhibition of human 5α-reductases by polyphenols’, Biochemical Pharmacology, pp. 1165-1176.

Kamatou, G.P.P., Ilze, V., Alvaro, M.V. & Brian M.L., 2013, ‘Menthol: A simple monoterpene with remarkable biological properties’, Phytochemistry, pp. 1-11.

Kepala BPOM RI, 2014, Peraturan kepala badan pengawas obat dan makanan Republik Indonesia nomor 7 tahun 2014 tentang pedoman uji toksisitas nonklinik secara in vivo, Jakarta, BPOM.

Kaushik, R., Gupta, D. & Yadav., R., 2011, ‘Alopecia: Herbal Remedies: A review’, IJPSR, 2(7), pp. 1631-1637.

Moghimipour, E., Salimi, A. & Jahromi, A.T., 2018. Influence of Chemical Permeation Enhancers on the in vitro Skin Permeation of Minoxidil through Excised Rat Skin: A Mechanistic Study. Iranian Journal of Pharmaceutical Sciences, 14(1), pp.97–110.

Oh, J.Y., Park, M.A. & Kim, Y.C., 2014. Peppermint oil promotes hair growth without toxic signs. Toxicological Research, 30(4), pp.297–304.

Patel, S., Vikas, S., Nagendra, S.C., Mayank, T. & Vinod, K.D., 2015, Evaluation of hair growth promoting activity of Phyllanthus niruri’, Avicenna J Phytomed, 5(6), pp. 512–519.

Patel, J.R. et al., 2011. Phyllanthus amarus: Ethnomedicinal uses, phytochemistry and pharmacology: A review. Journal of Ethnopharmacology, 138, pp.286–313.

Patel, S. et al., 2015. Hair Growth: Focus on Herbal Therapeutic Agent. Current Drug Discovery Technologies, 12, pp.21–42.

Rajesh, N., Siddaramaiah, Gowda, D.V., Somashekar, C.N., 2010, ‘Formulation and evaluation of biopolymer based transdermal drug delivery’, Int J Pharmacy Pharm Sci, 2(2), pp. 142-147.

Thorat, R., 2010, ‘Herbal treatment for hair loss’, Int J Pharm Technol, 2(4), pp. 497–503.

Verma, S., Hitender, S. & Munish, G., 2014, ‘Phyllanthus amarus: A Review’, JPP, 3(2), pp.18-22.




DOI: https://doi.org/10.22146/mot.37303

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