OPTIMATIZATION OF SUCROSE AND ASPARTAME COMPOSITION AS SWEETENING AGENT IN MENGKUDU FRUIT ETHANOLIC EXTRACT EFFERVESCENT-TABLET FORMULATION

https://doi.org/10.22146/tradmedj.8252

Galih Pratiwi(1), Triana Hertiani(2*), Mufrod Mufrod(3)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Mengkudu (Morinda citrifolia L.) has been widely used as traditional medicine. Its unpleasant smell and flavor urge a more acceptable dosage formulation. The aim of this research was to optimize the composition of sucrose and aspartame as sweetening agent in effervescent tablet formulation by using Simplex Lattice Design method. Effervescent tablets were produced by fusion method in five (5) different formulas, i.e. formula I (100% sucrose), II (suucrose-aspartame=75%:25%), III (sucrose-aspartame=50%:50%), IV (sucrose-aspartame=25%:75) dan V (100% aspartame). Effervescent granules were evaluated for mass density, flowing time, tapping index and compactibility characteristics. The effervescent tablets were tested for weight uniformity, hardness, friability, and disintegration time characteristics as well as TLC profile chromatogram. Data was analyzed by one way ANOVA, Scheffe method and Kruskall-Wallis with significance level 95%. The tablet acceptability was tested among 30 respondents. The results showed that the different composition of sucrose-aspartame influence the physical characteristics of granules and tablets effervescent produced. More sucrose content will increase the hardness, lower the friability but prolong the disintegration time. 70% respondents chose formula III as the best formula. Evaluation of SLD data recommended sucrose and aspartame in 42:58 proportion as the most optimum formula.

Keywords


mengkudu, effervescent tablet, sucrose, aspartame, SLD



References

Adyana, I.K., Yulinah, E., Soemardji, A.A., Kumolosari, E., Iwo, M.I., Sigit, J.I., dan Suwendar, 2004, Uji Aktivitas Antidiabetes Ekstrak Etanol Buah Mengkudu (Morinda citrifolia L.), Acta Pharmaceutica Indonesia, Vol. XXIX, No. 2, 2004 - 43

Ansel, H. C., Popovich, N. G., and Allen, L.V., 2005, Pharmaceutical Dosage Forms and Drug Delivery System, 8th Ed., Philadelpia, Lippincott Williams and Walkins, 133-200

Asahina, A.Y., Ebesu, J.S.M., Ichinotsubo, D., Tongson J, and Hokama, Y., 1994, Effect of okadaic acid (OA) and Noni fruit extraction in the synthesis of tumor necrosis factor-a (TNF-a) by peripheral blood mononuclear (PBN) cells in vitro. The Procedings of the International Symposium of Ciguatera and Marine Natural Products, 197-205 cit Wang, M.Y., West, B.J., Jensen, C.J., Nowicki, D., Chen, S., Palu, A.K., and Anderson, G., 2002, Morinda citrifolia (Noni): A literature review and recent advances in Noni research, Acta Pharmacologica Sinica, 23 (13): 1127–1141

Bangun, A. P dan Sarwono, B., 2002, Khasiat dan Manfaat Mengkudu, Bogor, Agromedia Pustaka, 5-24

Bolton, S., 1997, Optimization techniques. In: Pharmaceutical Statistics:

Practical and Clinical Applications, 3rd ed., New York, Marcel Dekker Inc., 610-619

DepKes RI, 1979, Farmakope Indonesia, Edisi III, Jakarta Departemen Kesehatan Republik Indonesia

Fonner, D.E., Anderson, H.R., and Banker, G.S., 1981, Granulation and Tablet Characteristic, In: Lieberman, H.A., Lachman, L., (Eds.), Pharmaceutical Dosage Forms : Tablets, New York, Marcel Dekker Inc., 2, 216-231

Hokama, Y., 1993, The effect of Noni fruit extract (Morinda citrifolia, Indian mulberry) on thymocytes of BALB/c mouse, FASEBJ, 7(10), A866 cit Wang, M.Y., West, B.J., Jensen, C.J., Nowicki, D., Chen, S., Palu, A.K., and Anderson, G., 2002, Morinda citrifolia (Noni): A literature review and recent advances in Noni research, Acta Pharmacologica Sinica, 23 (13): 1127–1141

Khankari and Hontz, 1997, Binder and Solvent, in: Parikh, M., Handbook Of Pharmaceutical Granulation Technology, Volume 8, New York, Marcel Dekker, Inc., 66-67

Lee, R.E., 2001, Effervescent tablets: Key facts about a unique, effective dosage form, Amerilab Technologies, New Hope

Mohrle, R., 1980, Effervescent Tablets in: Lieberman, H.A., Lachman, L.S., (Eds), Pharmaceutical Dosage Forms: Tablets, Vol. 1, New York, Marcel Dekker Inc., 225-255

Noor, S.U. dan Ratih, D., 2008, Uji Aktivitas Imunomodulator Ekstrak Etanol Buah Mengkudu (Morinda citrifolia L.), dalam Prosiding Kongres Ilmiah XVI Ikatan Sarjana Farmasi Indonesia 2008, ISFI, Yogyakarta

Parrott, E. L., 1971, Pharmaceutical Technology Fundamental Pharmaceutics, 3th Ed. Minneapolis, Burgess Publishing Company, 64-68, 82

Ramamoorthy P. K., and Bono A., 2007, Antioxidant Activity, Total Phenolic and Flavonoid Content Of Morinda citrifolia Fruit Extracts From Various Extraction Processes, Vol 2 (2007) 70-80

Samsi, M., 2007, Ekstrak Benalu Teh (Scurrula oortiana) Sebagai Imunomodulator dan Antitumor Infeksi MDV, Disertasi, Bogor, Institut Pertanian Bogor

Sasmito, E., Yuniarti, N., dan Soegihardjo, C.J., 2008, Mekanisme imunomodulator ekstrak buah mengkudu (Morinda citrifolia L.) pada mencit Balb/c yang diinduksi vaksin Hepatitis B, MOT, 13(43)

Shotton, E., Hersey, J. A., and Wray, P.E., 1976, Compaction and Compression, In: Lachman, L., Lieberman, H.A., Kanig, J.L., (Eds), The Theory and Practice of Industrial Pharmacy, 2nd Ed., Philadelpia, Lea and Febiger, 296-318

Sugita, S., 2006, Pengaruh Kadar PEG 6000 terhadap Mutu Fisik Tablet Ekstrak Mengkudu dalam Dispersi Padat Ekstrak Mengkudu-PEG 6000 yang Dibuat secara Cetak Langsung, Tesis, Surabaya, Universitas Airlangga

Sulistyaningsih, Y., 2002, Pembuatan Tablet Ekstrak Kering Buah Mengkudu (Morinda citrifolia L.) dengan Variasi Bahan Pengisi Menggunakan Metode Granulasi Kering, Skripsi, Yogyakarta, Fakultas Farmasi Universitas Gadjah Mada

Thomas, A.N.S, 2001, Tanaman Obat Tradisional, Jilid 1, Yogyakarta, Kanisius, 64

Wang, M.Y., West, B.J., Jensen, C.J., Nowicki, D., Chen, S., Palu, A.K., and Anderson, G., 2002, Morinda citrifolia (Noni): A literature review and recent advances in Noni research, Acta Pharmacologica Sinica, 23 (13): 1127–1141

Winarti, C., 2005, Peluang Pengembangan Minuman Fungsional dari Buah Mengkudu (Morinda citrifolia), Bogor, Balai Besar Penelitian dan Pengembangan Pasca Panen Pertanian



DOI: https://doi.org/10.22146/tradmedj.8252

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