Surface Modification of Multi-Walled Carbon Nanotubes with Polysaccharides

https://doi.org/10.22146/ajche.69866

Francisca Larasati(1), Yuni Kusumastuti(2*), Aswati Mindaryani(3), Rochmadi Rochmadi(4), Murni Handayani(5)

(1) Department of Chemical Engineering, Universitas Gadjah Mada, Jl. Grafika 2, 55281, Yogyakarta Indonesia
(2) Department of Chemical Engineering, Universitas Gadjah Mada, Jl. Grafika 2, 55281, Yogyakarta Indonesia
(3) Department of Chemical Engineering, Universitas Gadjah Mada, Jl. Grafika 2, 55281, Yogyakarta Indonesia
(4) Department of Chemical Engineering, Universitas Gadjah Mada, Jl. Grafika 2, 55281, Yogyakarta Indonesia
(5) Research Centre for Advanced Materials - National Research and Innovation Agency (BRIN), Kawasan Puspiptek,Tangerang Selatan, 15314, Banten, Indonesia
(*) Corresponding Author

Abstract


Multi-walled carbon nanotubes (MWCNTs) are known as efficient drug carriers. To improve their interaction with other materials, surface modification of MWCNTs is necessary. In this work, MWCNTs were functionalized with acid and polysaccharides (chitosan and gelatin). The functionalization process was done via modification with acid solutions of nitric acid, sulfuric acid, and a mixture of nitric acid-sulfuric acid first, followed by functionalization with chitosan and gelatin. To achieve the optimum condition of MWCNTs functionalization, the reaction time, temperature, and acid ratio were varied. Furthermore, the effect of chitosan and gelatin addition into MWCNTs was studied at various mass ratios. The synthesized materials were characterized by Fourier transform infrared spectrophotometer, Boehm titration, and dispersion test. The Boehm titration results showed that the acid functional groups had been attached successfully to MWCNTs surface. The amount of acid functional groups increased along with reaction time. The highest amount of acidic group obtained from the data was 2.33 mmol/g. It was achieved when MWCNTs reacted with nitric acid for 24 hours. Temperature and acid ratio variations on the MWCNTs functionalization did not provide significant results. From the FTIR data, sharp peaks at 3480 cm-1 and 1040 cm-1 indicates a -CONH bond, which shows that chitosan and gelatin have been successfully grafted onto MWCNTs surface via an amide linkage. Moreover, the dispersion test showed that the functionalized materials were stable for 48 hours.


Keywords


MWCNTs, Surface functionalizations, Drug carrier, Polysaccharides, Chitosan, Gelatin

Full Text:

PDF


References

Aslani, M., Meskinfam, M., & Aghabozorg, H., 2017. “In Situ biomimetic synthesis of gelatin-carbon nanotube-hydroxyapatite biocomposites as bone filler”, Orient. J. Chem, 33, 235-241.

Boncel, S., Zając, P. and Koziol, K.K., 2013. “Liberation of drugs from multi-wall carbon nanotube carriers”, Journal Control. Release, 169(1-2), 126-140.

Carson, L., Kelly-Brown, C., Stewart, M., Oki, A., Regisford, G., Luo, Z., & Bakhmutov, V. I., 2009. “Synthesis and characterization of chitosan–carbon nanotube composites”, Mater. Lett., 63(6-7), 617-620.

Cirillo, G., Hampel, S., Spizzirri, U.G., Parisi, O.I., Picci, N. and Iemma, F., 2014. “Carbon nanotubes hybrid hydrogels in drug delivery: A perspective review”, BioMed Res. Inter., 2014, 825017.

Datsyuk, V., Kalyva, M., Papagelis, K., Parthenios, J., Tasis, D., Siokou, A., Kallitsis, I., and Galiotis, C., 2008. “Chemical oxidation of multi-walled carbon nanotubes”, Carbon, 46(6), 833-840.

Hsan, N., Dutta, P. K., Kumar, S., Das, N., & Koh, J., 2020. “Capture and chemical fixation of carbon dioxide by chitosan grafted multi-walled carbon nanotubes”, J. CO2 Util., 41, 101237.

Kwon, S., Singh, R. K., Perez, R. A., Abou Neel, E. A., Kim, H.-W., dan Chrzanowski, W., 2013. “Silica-based mesoporous nanoparticles for controlled drug delivery”, J. Tissue Eng., 4, 204173141350335.

Kwok, Karl & Vincent, Erica & Gibson, James, 2017. Pharmacology and Therapeutics for Dentistry (7th edition): Antineoplastic Drugs, Elsevier.

Larasati, F. (2021). Kinetic and Isotherm Studies of Functionalized Multi-Walled Carbon Nanotube (MWCNT) with Biopolymer Variations as Drug Carrier [Master’s thesis, Universitas Gadjah Mada]. ETD UGM: Theses and Dissertations Repository. http://etd.repository.ugm.ac.id/penelitian/detail/203068

Le Hoa, T.M., 2018. “Characterization of multi-walled carbon nanotubes functionalized by a mixture of HNO3/H2SO4”, Diam. Relat. Mater., 89, 43-51.

Lombardo, D., Kiselev, M.A. and Caccamo, M.T., 2019. “Smart nanoparticles for drug delivery application: development of versatile nanocarrier platforms in biotechnology and nanomedicine”, J. Nanomater., 2019, 3702518.

Mahajan, S., Patharkar, A., Kuche, K., Maheshwari, R., Deb, P.K., Kalia, K. and Tekade, R.K., 2018. “Functionalized carbon nanotubes as emerging delivery system for the treatment of cancer”, Int. J. Pharm., 548(1), 540-558.

Malek, S.K., Gabris, M.A., Jume, B.H., Baradaran, R., Aziz, M., Abd Karim, K.J.B. and Nodeh, H.R., 2019. “Adsorption and in vitro release study of curcumin form polyethyleneglycol functionalized multi walled carbon nanotube: kinetic and isotherm study”, DARU J. Pharm. Sci., 27(1), 9-20.

Moore, T.L., Grimes, S.W., Lewis, R.L. and Alexis, F., 2014. “Multilayered polymer-coated carbon nanotubes to deliver dasatinib”, Mol. Pharm., 11(1), 276-282.

Putri, R. G., Syafera, Y., Larasati, F., Putri, N. R. E., Handayani, M., & Kusumastuti, Y., 2020. “Effect of reaction time on modification of multi-walled carbon nanotubes with HNO3”. IOP Conference Series: Mater. Sci. Eng., 742(1), 012038.

Saleh, T. A., 2011. “The influence of treatment temperature on the acidity of MWCNT oxidized by HNO3 or a mixture of HNO3/H2SO4”, Appl. Surf. Sci., 257(17), 7746-7751.

Sharmeen, S., Rahman, A. M., Lubna, M. M., Salem, K. S., Islam, R., & Khan, M. A., 2018. “Polyethylene glycol functionalized carbon nanotubes/gelatin-chitosan nanocomposite: An approach for significant drug release”, Bioact. Mater., 3(3), 236-244.

Sobh, R. A., Nasr, H. E. S., & Mohamed, W. S., 2019. “Formulation and in vitro characterization of anticancer drugs encapsulated chitosan/multi-walled carbon nanotube nanocomposites”, J Appl Pharm Sci, 9, 32-40.

Wong, B.S., Yoong, S.L., Jagusiak, A., Panczyk, T., Ho, H.K., Ang, W.H. and Pastorin, G., 2013. “Carbon nanotubes for delivery of small molecule drugs”, Adv. Drug Deliv. Rev., 65(15), 1964-2015.

Yuliantoro, H., Kusumastuti, Y., Mindaryani, A., Handayani, M., & Rochmadi., 2021. “Functionalization of single-walled carbon nanotubes with a HNO3/H2SO4 mixture through different treatments: A DFT supported study”, AIP Conf. Proceed., 2349(1), 020071



DOI: https://doi.org/10.22146/ajche.69866

Article Metrics

Abstract views : 429 | views : 177

Refbacks

  • There are currently no refbacks.


ASEAN Journal of Chemical Engineering  (print ISSN 1655-4418; online ISSN 2655-5409) is published by Chemical Engineering Department, Faculty of Engineering, Universitas Gadjah Mada.