Penggunaan kontrasepsi hormonal dan kejadian kanker payudara di rumah sakit Dr. Sardjito

https://doi.org/10.22146/bkm.22812

Nuratul Awaliyah(1*), Heru Pradjatmo(2), Hari Kusnanto(3)

(1) Departemen Biostatistik, Epidemiologi, dan Kesehatan Populasi, Fakultas Kedokteran, Universitas Gadjah Mada
(2) Departemen Obstetri dan Ginekologi, Fakultas Kedokteran, Universitas Gadjah Mada
(3) Departemen Biostatistik, Epidemiologi, dan Kesehatan Populasi, Fakultas Kedokteran, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


The use of hormonal contraceptives relates with the incidence of breast cancer in Dr. Sardjito Yogyakarta 

Purpose: This study aimed to determine whether women using the contraceptive pill can cause breast cancer.

Methods: A case control study was conducted August to October 2016 with 250 patients.

Results: Factors that were associated with breast cancer were: type of pill with adjusted OR = 1.66 (95% CI = 1.21 to 2.28; p = 0.001), duration of consumption with adjusted OR = 2.25 (95% CI = 1.04 to 4.84; p = 0.037), and the period of last hormonal contraception with adjusted OR = 2.41 (95% CI = 1. 15 to 5.05; p = 0.020). This study showed that the use of hormonal contraceptives raises the risk of breast cancer.

Conclusion: Women should play an active role in breast cancer prevention programs through early detection and treatment. Health services need to explain the potential risks of hormonal contraceptive.


Keywords


breast cancer; hormonal contraceptive; prevention programs



References

  1. Bott, R. Data dan informasi Kesehatan Situasi Penyakit Kanker.Igarss 2014. (1). 1-5. Doi:10.1007/s13398-014-0173-7.
  2. Kemenkes. Pusat Data dan Informasi Kementerian Kesehatan RI; 2015.
  3. WHO. International Agency for Research on Cancer (IARC) / WHO. (2012). Globocan 2012: Estimated cancer incidence, mortality, and prevalence worldwide in 2012. Retrieved from http://globocan.iarc.fr
  4. Althuis MD, Fergenbaum JH, Garcia-Closas M, Brinton LA, Madigan MP, Sherman ME. Etiology of hormone receptor–defined breast cancer: a systematic review of the literature. Cancer Epidemiology and Prevention Biomarkers. 2004 Oct 1;13(10):1558-68.
  5. Mujiati, I. Pelayanan KB Pasca Persalinan dalam Upaya Mendukung Percepatan Penurunan Angka Kematian Ibu. Buletin Jendela Data Dan Informasi Kesehatan 2014; 2:11– 16.
  6. BKKBN. Pelayanan Kontrasepsi Tabel. Jumlah dan persentase peserta kb baru kumulatif menurut metode kontrasepsi; 2015.
  7. Kemenkes. Situasi dan Analisis Keluarga Berencana. Kementerian Kesehatan Republik Indonesia; 2014.
  8. Ichida M, Kataoka A, Tsushima R, Taguchi T. No increase in breast cancer risk in Japanese women taking oral contraceptives: a case-control study investigating reproductive, menstrual and familial risk factors for breast cancer. Asian Pac J Cancer Prev. 2015;16(9):3685-90.
  9. Narod SA, Dubé MP, Klijn J, Lubinski J, Lynch HT, Ghadirian P, Provencher D, Heimdal K, Moller P, Robson M, Offit K. Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Journal of the National Cancer Institute. 2002 Dec 4;94(23):1773-9.
  10. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. The Lancet. 1996 Jun 22;347(9017):1713-27.
  11. Abidin, Syahrir, H., & Richa. Faktor Risiko Kejadian Kanker Payudara di RSUD Labuang Baji Makassar. Ilmiah Kesehatan Diagnosis 2014;4: 236-242
  12. Kadrianti, E. Faktor Risiko Kejadian Kanker Payudar Di RSUP DR Wahidin Sudirohusodo Makasar 2011;17: 1–9.
  13. Susetio, B. anyar. Kanker Payudara Di RSUP Dr. Sardjito. UGM;2011.
  14. Sihombing, M., Sapardin, A. N., Penelitian, B., & Ri, K. K. (n.d.). Faktor Risiko Tumor Payudara Pada…..(Marice S, Aprildah Nur S).
  15. Lee NC, Rosero-Bixby L, Oberle MW, Grimaldo Vásquez C, Whatley AS, Rovira EZ. A case-control study of breast cancer and hormonal contraception in Costa Rica.
  16. Li CI, Beaber EF, Tang MT, Porter PL, Daling JR, Malone KE. Effect of depo-medroxyprogesterone acetate on breast cancer risk among women 20-44 years of age. Cancer research. 2012 Feb 27:canres-4064.
  17. Piasecka D, Składanowski AC, Kordek R, Romańska HM, Sądej R. Aspects of progesterone receptor (PR) activity regulation-impact on breast cancer progression. Postepy biochemii. 2015;61(2):198-206.
  18. White E1, Malone KE, Weiss NS, D. J. Breast cancer among young;2014.
  19. La Vecchia C, Negri E, Franceschi S, Talamini R, Amadori D, Filiberti R, Conti E, Montella M, Veronesi A, Parazzjni F, Ferraroni M. Oral contraceptives and breast cancer: a cooperative Italian study. International journal of cancer. 1995 Jan 17;60(2):163-7.
  20. Strom BL, Berlin JA, Weber AL, Norman SA, Bernstein L, Burkman RT, Daling JR, Deapen D, Folger SG, Malone KE, Marchbanks PA. Absence of an effect of injectable and implantable progestin-only contraceptives on subsequent risk of breast cancer. Contraception. 2004 May 1;69(5):353-60.
  21. Madelenat, P., & Koskas, M. [Update on the progestin-only contraception]. Journal de Gynécologie, Obstétrique et Biologie de La Reproduction 2018. http://doi.org/10.1016/j.jgyn.2008.06.013
  22. Karim SM, Baeshen W, Neamatullah SN, Bin B. Oral contraceptives, abortion and breast cancer risk: a case control study in Saudi Arabia. Asian Pac J Cancer Prev. 2015;16(9):3957-60.
  23. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: a cancer journal for clinicians. 2011 Mar 1;61(2):69-90.
  24. Brinton LA, Gammon MD, Malone KE, Schoenberg JB, Daling JR, Coates RJ. Modification of oral contraceptive relationships on breast cancer risk by selected factors among younger women. Contraception. 1997 Apr 1;55(4):197-203.
  25. Indrati R. Faktor Faktor Risiko yang Berpengaruh Terhadap Kejadian Kanker Payudara Wanita. Jurnal Epidemiologi. 2005.
  26. Ardiana A, Negara HW. Analisis Faktor Risiko Reproduksi yang Berhubungan dengan Kejadian Kanker Payudara pada Wanita. Jurnal Keperawatan Padjadjaran. 2013;1(2).
  27. Gaffield ME, Culwell KR, Ravi A. Oral contraceptives and family history of breast cancer. Contraception. 2009 Oct 1;80(4):372-80.
  28. Iatrakis G, Iavazzo C, Zervoudis S, Koumousidis A, Sofoudis C, Kalampokas T, Salakos N. The role of oral contraception use in the occurrence of breast cancer. A retrospective study of 405 patients. Clinical and experimental obstetrics & gynecology. 2011;38(3):225-7.
  29. Rohan TE, McMichael AJ. Oral contraceptive agents and breast cancer: a population-based case-control study. The Medical Journal of Australia. 1988 Nov;149(10):520-6.
  30. Anggorowati L. Faktor risiko kanker payudara wanita. Jurnal Kesehatan Masyarakat. 2013;8(2).
  31. Kallel M, Elloumi F, Khabir A, Ghorbal L, Chaabouni S, Amouri H, Frikha M, Daoud J. Breast cancer in young women in southern Tunisia: Anatomical study and clinical prognostic factors: About a series of 83 patients. Reports of Practical Oncology & Radiotherapy. 2015 May 1;20(3):155-60.



DOI: https://doi.org/10.22146/bkm.22812

Article Metrics

Abstract views : 3034 | views : 4098

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2017 Berita Kedokteran Masyarakat



Berita Kedokteran Masyarakat ISSN 0215-1936 (PRINT), ISSN: 2614-8412 (ONLINE).

Indexed by:

 

Web Analytics Visitor Counter