Usia menarche sebagai faktor risiko kejadian preeklamsia dan eklamsia

Astrid Kizy Primadani(1*), Elisabeth S Herini(2), Djaswadi Dasuki(3)

(1) Departemen Biostatistik, Epidemiologi dan Kesehatan Populasi Fakultas Kedokteran Universitas Gadjah Mada
(2) Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Gadjah Mada
(3) Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Gadjah Mada
(*) Corresponding Author


Age of menarche as a risk factor for preeclampsia and eclampsia


The purpose of this study is to determine the effect of menarche age on the incidence of preeclampsia and eclampsia.


The observational study with the case-control design was conducted involving 90 pregnant and postpartum women. The bivariable analysis used T-test and McNemar test, while multivariable analysis using conditional logistic regression.


The average age of menarche in the preeclampsia group was one year younger than the non-preeclampsia group. Any increase in one year of age of menarche lowers the risk of preeclampsia and eclampsia by 78%. Risk factors for preeclampsia are increased in pregnant women at age> 35 years and have body mass index before pregnancy> 25 kg/m2.


There is a significant relationship between age of menarche and the incidence of preeclampsia and eclampsia. Body mass index before pregnancy is a confounding factor of the association between age of menarche and the incidence of preeclampsia and eclampsia.


preeclampsia; eclampsia; age of menarche; case-control; body mass index


  1. Cunningham, F, G., Corton, M, M., Leveno, K., and Bloom, S., William Obstetrics, 24eth ed, McGraw-Hill Education, USA; 2014.
  2. SDKI. Survei Demografi dan Kesehatan Indonesia Tahun 2012; 2012.
  3. Bilano, V.L., Ota, E., Ganchimeg, T., Mori, R. and Souza, J.P. Risk factors of pre-eclampsia/eclampsia and its adverse outcomes in low-and middle-income countries: a WHO secondary analysis, PLOS one 2014;9(3): e91198.
  4. Ros, H.S., Lichtenstein, P., Ekbom, A. and Cnattingius, S. Tall or short? Twenty years after preeclampsia exposure in utero: comparisons of final height, body mass index, waist-to-hip ratio, and age at menarche among women, exposed and unexposed to preeclampsia during fetal life, Pediatric research 2001;49(6): 763-769.
  5. Haelterman, E., Marcoux, S., Croteau, A. and Dramaix, M. Population-based study on occupational risk factors for preeclampsia and gestational hypertension. Scand J Work Environ Health 2007;33(4): 304-317.
  6. Rudra, C.L. and Williams, M.A. BMI as a modifying factor in the relations between age at menarche, menstrual cycle characteristics, and risk of preeclampsia, Gynecological endocrinology 2005;21(4): 200-205.
  7. Abetew, D.F., Enquobahrie, D.A., Dishi, M., Rudra, C.B., Miller, R.S. and Williams, M.A. Age at menarche, menstrual characteristics, and risk of preeclampsia, ISRN obstetrics and gynecology; 2011. Accessed:
  8. Lai, T.C., Leung, G.M. and Schooling, C.M. Maternal Age of Menarche and Blood Pressure in Adolescence: Evidence from Hong Kong’s “Children of 1997” Birth Cohort. PLoS One 2016;11(7): 0159855.
  9. Kumari, N., Dash, K., Singh, R. Relationship between Maternal Age and Preeclampsia, IOSR-JDMS 2016;15(12): 55-57.
  10. Duckitt K., Harington, D. Risk factors for preeclampsia at antenatal Booking: systematic review of controlled studies, BMJ 2005;330: 549-50.
  11. Lamminpää, R., Vehviläinen-Julkunen, K., Gissler, M. and Heinonen, S. Preeclampsia complicated by advanced maternal age: a registry-based study on primiparous women in Finland 1997–2008. BMC pregnancy and childbirth 2012. Accessed:
  12. Optisari, C. dan Andayasari, L. Parity, education level and risk for (pre-) eclampsia in selected hospitals in Jakarta, Health Science Indones 2014;5(1): 35-39.
  13. Manandhar, B.L., Chongstuvivatwong, V. and Geater, A. Antenatal care and severe pre-eclampsia in Kathmandu valley, JCMC 2014;3(4): 43-47.
  14. Chang, P.J., Chu, L.C., Hsieh, W.S., Chuang, Y.L., Lin, S.J. and Chen, P.C. Working hours and risk of gestational hypertension and pre-eclampsia. Occupational medicine 2010; 60(1): 66-71.
  15. Lahiri, A., Bandyopadhyay, S., Adhya, S., Ghosh, S., Ray, S. and Haldar, S. A Study on Age at Menarche with its Relation to Pregnancy Induced Hypertension, JIAFM; 2014 36(4): 359-362.


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