Korelasi indeks trigliserida glukosa terhadap tingkat keparahan neuropati perifer diabetik pada stroke iskemik
https://doi.org/10.22146/bns.v21i1.109493 Rahma Yuniar Faradyni(1*), Ismail Setyopranoto(2), Indra Sari Kusuma Harahap(3)
(1) Gadjah Mada University
(2) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan, Universitas Gadjah Mada, Yogyakarta/RSUP Dr Sardjito
(3) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan, Universitas Gadjah Mada, Yogyakarta/RSUP Dr Sardjito
(*) Corresponding Author
Abstract
Background: Diabetic peripheral neuropathy is a complication of diabetes mellitus that occurs in approximately 50% of patients and is the leading cause of increased morbidity and mortality. The Triglyceride-Glucose Index (TyG) can be an alternative, more accessible indicator for assessing insulin resistance. Insulin resistance plays a role in macrovascular and microvascular complications, including neuropathy and ischemic stroke.
Objective: This study aims to examine the correlation between the TyG Index and the severity of diabetic peripheral neuropathy based on the NDS-INA score in ischemic stroke patients.
Methods: This study used a cross-sectional design. Medical records were used to obtain laboratory data, and the severity of diabetic neuropathy was assessed using the Neuropathy Disability Score–Indonesian Version (NDS-INA) based on physical examination results. The correlation between laboratory data in the form of the triglyceride-glucose index (TyG) profile and the severity of diabetic peripheral neuropathy was analyzed statistically.
Results: Of the 85 patients, 51.8% had moderate to severe diabetic peripheral neuropathy. Correlation tests showed a significant positive correlation between the TyG index and the severity of diabetic peripheral neuropathy (p=0.001; r=0.382). Bivariate tests showed a significant relationship between the TyG index and the severity of diabetic peripheral neuropathy (p=0.001; OR 6.75).
Conclusion: The results showed that the higher the TyG index, the more severe the diabetic peripheral neuropathy in ischemic stroke patients.
ABSTRAK
Latar Belakang: Neuropati perifer diabetik merupakan komplikasi diabetes melitus yang terjadi pada sekitar 50% pasien dan merupakan penyebab utama peningkatan morbiditas dan mortalitas. Indeks trigliserida glukosa (TyG) dapat menjadi alternatif indikator yang lebih mudah diakses untuk menilai resistensi insulin. Resistensi insulin berperan dalam komplikasi makrovaskular dan mikrovaskular, termasuk neuropati dan stroke iskemik.
Tujuan: Penelitian ini bertujuan untuk mengkaji korelasi antara indeks TyG dan keparahan neuropati perifer diabetik berdasarkan skor NDS-INA pada pasien stroke iskemik.
Metode: Penelitian ini menggunakan desain potong lintang. Data rekam medis digunakan untuk memperoleh data laboratorium dan tingkat keparahan neuropati diabetik dinilai menggunakan skor Neuropathy Disability Score–Indonesian Version (NDS-INA) berdasarkan hasil pemeriksaan fisik. Korelasi antara data laboratorium berupa profil indeks TyG dengan tingkat keparahan neuropati perifer diabetik dianalisis secara statistik.
Hasil: Dari 85 pasien, sebanyak 51,8% memiliki tingkat keparahan neuropati perifer diabetik sedang-berat. Uji korelasi menunjukkan korelasi positif yang signifikan antara indeks TyG dengan tingkat keparahan neuropati perifer diabetik (p=0,001; r=0,382). Uji bivariat menunjukkan hubungan yang signifikan antara indeks TyG dan tingkat keparahan neuropati perifer diabetik (p=0,001; OR 6,75).
Kesimpulan: Hasil penelitian menunjukkan bahwa semakin besar kadar indeks TyG maka semakin berat tingkat keparahan neuropati perifer diabetik pada pasien stroke iskemikKeywords
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DOI: https://doi.org/10.22146/bns.v21i1.109493
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