Synthesis and Biological Activity of Ni(II), La(III), and Ce(IV) Complexes with 8-Hydroxy-7-iodo-6-((4-sulfophenyl)diazinyl)quinoline-5-sulfonic Acid Ligand

Noora Qasem Muhi; Alyaa Khider Abbas

doi:10.22146/ijc.110573

Synthesis and Biological Activity of Ni(II), La(III), and Ce(IV) Complexes with 8-Hydroxy-7-iodo-6-((4-sulfophenyl)diazinyl)quinoline-5-sulfonic Acid Ligand

https://doi.org/10.22146/ijc.110573

Noora Qasem Muhi^(1*), Alyaa Khider Abbas⁽²⁾

(1) Department of Chemistry, College of Science, University of Baghdad, Al Jadriya Street, Baghdad 10071, Iraq
(2) Department of Chemistry, College of Science, University of Baghdad, Al Jadriya Street, Baghdad 10071, Iraq
(*) Corresponding Author

Abstract

In this study, a new azo ligand, 8-hydroxy-7-iodo-6-((4-sulfophenyl)diazinyl)quinoline-5-sulfonic acid (HAQ), was synthesized from 8-hydroxy-7-iodo-quinoline-5-sulfonic acid using a diazotization-coupling procedure and then complexed with La(III), Ni(II), and Ce(IV) ions. The ligand and its metal complexes were analyzed using elemental analysis, FTIR, UV-vis, ¹H-NMR, TGA, SEM, ICP, and XRD techniques. Spectral and analytical results indicated the effective coordination of oxygen and nitrogen donor atoms, resulting in stable 1:1 (metal:ligand) of [La(HAQ)Cl₂(H₂O)₂]·5H₂O, and (1:2) of [Ce(HAQ)₂(SO₄)]·H₂O and [Ni(HAQ)₂(H₂O)₂]·4H₂O complexes. Thermal analysis has revealed that metal complexes are more thermally stable than their corresponding free ligands. SEM showed significant morphological modifications during complexation, whereas XRD patterns revealed an increase in crystallinity in the metal complexes. The antioxidant characteristics of the synthesized compounds were evaluated using the phosphomolybdate technique, with the Ce(IV) complex displaying the highest activity, most likely due to its redox capacity. Overall, the results highlight the potential of HAQ and its metal complexes as promising candidates for antioxidant and anticancer applications. These findings warrant further mechanistic studies and in vivo evaluations.

Keywords

ferron-azo ligand; lanthanide; transition metal complexes; antioxidant activity; cytotoxicity

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DOI: https://doi.org/10.22146/ijc.110573