IMPACT OF REPEATED ORAL DOSE OF MONOCROTOPHOS ON BLOOD ACETYLCHOLINESTERASE ACTIVITY IN GOAT (Capra hircus Linn)



M. Arifin(1*), N.P. Roxas(2), A.W. Tejada(3)

(1) Faculty of Animal Science, Diponegoro University, Semarang Indonesia
(2) Institute of Animal Science, College of Agriculture ,UP Los Banos, Philippines
(3) National Crops Protection Center, College of Agriculture, UP Los Banos, Philippines
(*) Corresponding Author

Abstract


Study on blood acetylcholine (AChE) inhibition due to monocrotophos poisoning on
goats was carried out by repeated oral dose followed by blood collection. Twelve yearling local male goats were fed daily with I20 gram of commercial concentrate (17% CP), and Napier grass ad Iibitum. The animals were treated orally with 0.006 mg/kg body weight of monocrotophos for 36 days dosing period. Blood samples from each animal were collected before dose treatment and afier every 3 days during the dosing period. It was observed that even with repeated daily oral dose of monocrotophos, there was no apparent adverse effect on the state of the animals’ health as well as the occurrence of any toxic symptoms, although the blood AChE inhibition was noticed. Observation on blood acetylcholinesterase indicated that its activity was inhibited by 21.59 a 4.16% (from 3.3 X 10*‘ 1 1.05 X 10*‘ to 2.4 X 1o'*‘i 7.0 X 10"’ mole substrate! rninute/liter blood). The blood acetylcholinesterase inhibition rate gradually increased up to day 9 of the dosing period followed by a relatively constant fluctuation.


Keywords


Repeated oral dose, Monocrotophos, Blood acetylcholinesterase activity, Goat

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