* Corresponding Author
The Difference Plasma Levels of Endotelin-1 in Type 2 Diabetes Mellitus Women with and without Hypertension
https://doi.org/10.22146/acta%20interna.22356 Enita Rahmawati Kurniatmaja(1*), Hemi Sinorita(2), Lutfan Budi Purnomo(3)
(1)
(2)
(3)
(*) Corresponding Author
Abstract
Background. Diabetes and hypertension are related to each other and have a strong pre-disposition on the incidence of atherosclerosis. The incidence of hypertension 2 times greater in patients with DM than non DM. Endothelial dysfunction underlies these events. Endothelial markers, endothelin-1 is known to affect blood pressure.
Aim. The aim of this study is to determine the difference plasma levels of endothelin-1 in type 2 diabetes mellitus in women with and without hypertension.
Methods. The cross sectional design was conducted on women with type 2 diabetes mellitus with and without hypertension at metabolic and endocrinology clinic, Dr. Sardjito General Hospital Yogyakarta from July 2010 until the sample met the criterias. Subjects were divided into two groups, type 2 DM woman with hypertension groups and without hypertension. ELISA sandwich’s method was used to measure plasma levels of endothelin-1. Characteristics of the study are presented in the form of mean Kurniaatmaja et al.
Results. In this research, the plasma levels of endothelin-1 in in type 2 diabetes mellitus in women with hypertension (n=32) and without hypertension (n=32) respectively 19.17±7.53 ng/ml and 13.75±6.19 ng/dl, and this difference was stastistically signifi cant with p= 0.003 CI 95% -8.87 to -1.97.
Conclusion. Plasma levels of endothelin-1 in type 2 diabetes woman with hypertension higher than without hypertension.
Keywords
Full Text:
PDFReferences
Cockram, C. S. , 2000. The epidemiology of diabetes mellitus in the Asia- Pacifi cregion. HKMJ; 6: 43-52. Schneider, J. G.,Tilly, N., Hierl, T., Sommer, U., Hamann, A., Dugi, K., Leidig-Bruckner, G., Kasperk, C. 2002. Elevated P lasma E ndothelin-1 L evels in Diabetes M ellitus. Am J Hyperten s; 15 (11): 967-72.
Suyono, S. 200 9. Diabetes Mellitus in
Indonesia. In: Aru, W, S., Bambang, S., K.,
A., Marcellus, SK, Siti, S., (eds). Textbook
of Medicine, Volume III. Issue 5. Faculty of
medicine, University of Indonesia: 187 3-79.
Epstein, M., Sowers, JR 1992. Diabetes
Mellitus and Hypertension. Hypertension;
(5): 403-18. Iglarz, M., Schiffrin, EL 2003.
Role of endothelin-1 in Hypertension.
Current Hypertension Reports; 5: 144-148.
Chakrabarti, S., Khan, ZA, Cukiernik,
M., Fukuda, G., Chen, S., Mukherjee,
S., 2002. Alteration of Endothelins: A
Common pathogenetic Mechanism in
Chronic Diabetic Complications. Int.
JNL. Experimental Diab. Res; 3: 217-231.
Aziza, L., Sja'bani, M., Haryana, SM, Soesatyo,
M., Sahadev, AH 2011. Endothelin-1
relationship with Hypertension in
Population Mlati, Sleman, Yogyakarta,
Indonesia. Indon J Med Assoc; 61: 237-42.
Dahlan, SM 2006. Large Sample in
Medical and Health Research. Jakarta.
PT.ARKANS: 14-102.
Perkumpulan Endokrinologi Indonesia
(PERKENI). Pengelolaan Diabetes
Melitus Tipe 2. Dalam Soewondo,
P (eds). Konsensus dan Pencegahan
Diabetes Mellitus Tipe-2 di Indonesia. PB
PERKENI. 2011: 6-47.
Takahashi, K., Ghatei, M.A., Lam, H.C.,
O’Halloran, D.J., Bloom, S.R. Elevated
Plasma Endothelin in Patients with
Diabetes mellitus. Diabetologia. 1990;
: 306-310.
Yang, W., Lu, J., Weng, J., Jia, W., Ji, L.,
Xiao, J. Prevalence of Diabetes among Men
and Women in China. New Engl J Med.
; 362: 12.
Ferrara, C. M., Golgberg, A.P., Nicklas, B.J.,
Sorkin, J.D., Ryan, A.S. Sex differences in
insulin action and body fat distribution
in overweight and obese middle-aged and
older men and Women in Appl Physiol
Nutr Metab. 2008;33(4): 784-790.
Ak, G., Buyukberber, S., Sevinc, A., Turk,
H.M., Ates, M., Sari, R., et al. The relation
between plasma endothelin-1 levels and
metabolic control, risk factors, treatment
modalities, and diabetic microangiopathy
in patients with type 2 diabetes mellitus.
J Diabs Compl. 2001;15(3):150
World Health Organization. Obesity :
Preventing and Managing the Global
Epidemic. World health organ tech rep
ser. 2000: 894.
Sanchez, S.S., Aybar, M.J., Velarde, M.S.,
Prado, M.M.,Carrizo, T. Relationship between
plasma endothelin-1 and Glycemic control
in type 2 Diabetes mellitus. Horm Metab res.
; 33:748-51.
Chobanian, A.V., Bakris, G.L., Black, H.R.,
Cushman, W.C., Green, L.A., Izzo, Z.L.
Jr., Jones, D.W., Materson, B.J., Oparil, S.,
Wright, J.T.Jr., Roccella, E.J. Joint National
Committee on Prevention, Detection,
Evaluation, and Treatment of High
Blood Pressure, National Heart, Lung,
and Blood Institute, National High Blood
Pressure Education Program Coordinating
Committee. Seventh report of the Joint
National Committee on Prevention,
Detection, Evaluation, and Treatment of
High Blood Pressure. Hypertension. 2003;
: 1206-52.
Bakris, G. Maximizing cardiorenal benefi t in
the management of hypertension: achieve
blood pressure goal, J Clin Hypertens
(Greenwich). 1999; 1:141-147.
Singh, U., Singh, R.G., Singh, S., Singh, S.
Plasma Endothelin Level in Hypertension
and Diabetes Mellitus. Med. Case Stud.
; 2(6) : 50-53.
Skalska, A.B., Pietrzyckab, A., Stepniewskib,
M. Correlation of endothelin-1 plasma
levels with plasma antioxidant capacity in
elderly patients treated for hypertension.
Clinical Biochemistry. 2009; 3: 42(4-5):
-364
Schneider, J.G., Tilly, N., Hierl, T., Sommer,
U., Hamann, A., Dugi, K., Leidig-
Bruckner, G., Kasperk, C. Elevated Plasma
Endothelin-1 Levels in Diabetes Mellitus.
Am J Hypertens. 2002; 15(11) : 967-72.
DOI: https://doi.org/10.22146/acta%20interna.22356
Article Metrics
Abstract views : 1010
| 
views : 553
Refbacks
- There are currently no refbacks.
Copyright (c) 2017 Acta Interna The Journal of Internal Medicine
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Acta Interna The Journal of Internal Medicine Indexed by:
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.