The Difference of Average Mean Platelet Volume (MPV) Values in Stable Angina Pectoris Patients with Symptoms of Depression and without Symptoms of Depression
Arief Wibawa(1*), Agus Siswanto(2), Hariadi Hariawan(3)
(1) 
(2) 
(3) 
(*) Corresponding Author
Abstract
Background: Depression is an independent predictor of cardiovascular events. Increased platelet reactivity is one of several possible mechanisms proposed to explain the relationship between psychosocial factors to coronary heart disease. Mean platelet volume (MPV) is an indicator of platelet activation. MPV associated with major cardiovascular events in coronary heart disease.
Objective: This study aimed to determine the average difference of mean platelet volume (MPV) in stable angina pectoris patients with symptoms of depression and without symptoms of depression.
Methods: The study design was a cross-sectional study. Sampling was carried out in sequence from Stable Angina Pectoris patients who were treated in the internal medicine department of Dr. Sardjito hospital Yogyakarta. MPV and HAD score were measured once on admission. Data presented as a descriptive analysis of the subjects' characteristics on average and standard deviation. The difference average of MPVbetween Stable Angina Pectoris patients with symptoms, depression and without symptoms depression assessed with Pearson's correlation. The results were considered at the signifi cance level of p <0.05.
Results: There were 40 subjects, consisting of 20 Stable Angina Pectoris patients with symptoms, depression and 20 Stable Angina Pectoris without symptoms depression. The difference average of MPV in this study was 7.56 ± 0.95 fl . Average MPV in Stable Angina Pectoris patients with symptoms depression was 8.45 ± 0.82 fl and without symptoms depression was 7.68 ± 0.99 fl with p = 0.009.
Conclusion: In this study, there was a statistically signifi cant difference of average MPV values in stable angina pectoris patients with symptoms of depression and patients without symptoms of depression.
Keywords
Full Text:
PDFReferences
Yoon S.G., Jung M.E. and Her S.H., 2011. Effect of Percutaneous Coronary Intervention on Depressive Mood in Elderly Patients, Journal Korean Geritr Soc; 15(2) J: 107-108
Januzzi S.C., Stein T.A., and Pasternak R.C., 2000. The Influence of Anxiety and Depression on Outcome of Patients with Coronary Artery Disease, Arch Intern Med; Vol. 160(10):1915-1916
Lett,H.S., James A., Blumenthal, Michael A. Babyak, and Andrew S., 2004. Depression as a Risk Factor for Coronary Artery Disease: Evidence,Mechanisms, and Treatment, Journal Psychosomatic Medicine; 66: 305 (abstract)
Yang A., Pizzuli L., and Luderitz R., 2006. Mean platelet volume as a marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris, Thrombosis research; 117: 371-377
Aşikar K., Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: an observational study (Anadolu Kardiyol Derg 2012; 12: 35-9).
Mumpuni, H. 2011. Hubungan Mean Platelet Volume (MPV) dengan Kejadian Kardiovaskular Mayor pada Penderita Sindroma Koroner Akut Selama Perawatan di Rumah Sakit.Tesis.Universitas Gadjah Mada Yogyakarta.
Larsson PT, Wallen NH, Hjemdahl P, 1993). Norepinephrine induced human platelet activation in vivo is only partly counteracted by aspirin.Circulation 1994; 89: 1951-7.
Yusuf S, Hawkin S, Ounpuu S, et al, 2004, Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004; 364:937– 952. [PubMed: 15364185]
Gray H.H., Keith D. Dawkins, John M. Morgan, and Iain A. Simpson, 2002. Lecture notes cardiology, Edisi 4, Erlangga Medical Series, Jakarta, 107-150.
Long B.C., 1996. Medical and Surgical Nursing–A nursing process approach, The C.V Mosby Company St. Louis, USA.
Burg M.M., Stress Behavior and Heart Disease, www.med.yale.edu/library/heartbk/8pdf
Parakh, K., Sakhuja, A., Bhat, U., and Ziegelstein, R.C. 2008. Platelet function inpatients with depression. Southern Medical
Journal 101:612-7.
DOI: https://doi.org/10.22146/acta%20interna.22392
Article Metrics
Abstract views : 1187 | views : 627Refbacks
- There are currently no refbacks.
Copyright (c) 2017 Acta Interna The Journal of Internal Medicine
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Acta Interna The Journal of Internal Medicine Indexed by:
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.