Correlation Between Neutrophil To Lymphocyte Ratio With Child Turcotte Pugh In Liver Cirrhosis Patients

Wiwiek Probowati; Putut Bayupurnama; Neneng Ratnasari

doi:10.22146/actainterna.27003

Correlation Between Neutrophil To Lymphocyte Ratio With Child Turcotte Pugh In Liver Cirrhosis Patients

https://doi.org/10.22146/actainterna.27003

Wiwiek Probowati^(1*), Putut Bayupurnama⁽²⁾, Neneng Ratnasari⁽³⁾

(1)
(2)
(3)
(*) Corresponding Author

Abstract

Background: Neutrophil to lymphocyte ratio (NLR) is an index that iswidely used these days. RNL has been widely studied as a predictor of poor survival and outcome in patients with liver cirrhosis, hepatocellular carcinoma, coronary heart disease, rheumatoid arthritis, sepsis and malignancy.
Objective: To determine whether there is a correlation between NLR with a score of Child turcotte pugh (CTP) in patients with liver cirrhosis in Dr. Sardjitogeneral Hospital.
Methods :The study design was cross-sectional study. The study began in December 2014 until the number of samples are met. The subjects of this study were patients with liver cirrhosis at affordable populations undergoing inpatient and outpatient care in the Dr. Sardjito Hospital that meet the inclusion and exclusion criteria. Venous blood test to measure neutrophils,
lymphocytes, albumin, total bilirubin, INR (Internationale normalized ratio). Data presented in the form of descriptive analysis of the characteristics of the study subjects such as the mean and standard deviation values of lymphocyte and neutrophil ratio scores CTP. For analyze the correlation between NLR with CTP scores Spearman nonparametric analysis p <0.05.
Results : There are 33 subjects in the study. Based on the results of this study found a positive significant correlation between the ratio of neutrophils to lymphocytes CTP with r = 0.749 and
p= <0.0001 and obtained the formula Y = 7.797 + 0,067x. Thus increasing of neutrophils to lymphocytes ratio positive correlated with the severity of liver cirrhosis.
Conclusion. There are positive correlation between the neutrophil to lymphocyte ratio with CTP scores in patients with liver cirrhosis.

Keywords

neutrophil to lymphocyte ratio, child turcotte pugh, liver cirrhosis

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References

Biyik M, Ucar R, Solak Y, Yalcin Solak, Gokhan Gungor, Ilker Polar, Ozlem O.. Cakir,2012Blood neutrophil-tolymphocyte ratio independently predicts survival in patients with liver cirrhosis of Internal Medicine, Division of Gastroenterology, Meram School of Medicine, Eur J Gastroenterol Hepatol.Apr;25(4):435-41.

Nurdjanah, S. 2014. Jilid II. Sirosis hati. In: A.W., Sudoyo, B., Setiyohadi, I., Alwi, M., Simadibrata, S., Setiati (eds).Buku Ajar Ilmu Penyakit Dalam Edisi 6. Interna Publishing, Jakarta.pp 668- 673.

Starr S.P & Raines, D., 2011, Cirrhosis: Diagnosis, Management, and Prevention, American Family Physician, Volume 84, Number 12, hal 1353-9.

Fock RA, BlattSL, Beutler B, Pereira J, Tsucita M., De Barros FE, Study of Lymphocyte subpopulation in bone marrow in a model of protein energy malnutrition 2010: 26: 1021-1028.

Naim Alkhouri, Gareth Morris-Stiff, Carla Campbell, 2012, Neutrophil to Lymphocyte Ratio: A New Marker for Predicting Steatohepatitis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease, Liver International ;32(2):297-302.

Muhammad Sopiyudin Dahlan, 2008, Statistik untuk Kedokteran dan Kesehatan, edisi 3, Penerbit Salemba Medika.

Jeffrey I. Zwicker, Reed E. Drews, 2007, Hematologic Disorders and the Liver, Schiff’s Diseases of the Liver, 10th Edition, Chapter 12.

Cervoni JP, Thevenot T, Weil D, Muel E, Barbot O., 2012, C-reactive protein predicts short term mortality in patients with cirrhosis, J Hepatology Jun;56(6): 1299-304.

Atakan Yesil, Suleyman Cosgun, Emrulah Erdem, Koray Kochan, 2013, The Relationship between fibosis level and blood neutrophile to lymphocyte ratio in chronic HBV patients, Akademic Gastroenteroloji Dergisi: 12(2) 66-68.

Byong Sun Oh, Jeong Won Jang, Jung Hyun Kwon, 2013, Prognostic value of C-reactive protein and neutrophil-tolymphocyte ratio in patients withhepatocellular carcinoma, BMC Cancer, 13:78.

Halazun, Ming Te Kuo, Tsung Hui Hu, Sheng Nan Lu, 2013, Neutrophil to Lymphocyte Ratio as a Predictor of Response to Peginterferon plus RibavirinTherapy for Chronic Hepatitis C, Disease Markers, volume 2014:534-540.

Alpasian, Tan og Lu and Ergon ekon Karagoz, 2014, Neutrophil to lymphocyte ratio acts: as a prognostic factor for patients with advanced hepatocelluler carcinoma, European Journal of Gastroenterology &Hepatology vol 26 no 3, p 23-45.

DOI: https://doi.org/10.22146/actainterna.27003