* Corresponding Author
CORRELATION BETWEEN MAGNESIUM SERUM LEVELS AND PEAK EXPIRATORY FLOW IN CHRONIC ASTHMA PATIENTS
https://doi.org/10.22146/acta%20interna.3866 Grendi Faneri Yonarko(1*), Suhardi Darmo Atmojo(2), Barmawi Hisyam(3)
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(*) Corresponding Author
Abstract
ABSTRACT
Background: Magnesium Serum in some previous studies had been related to asthma events and severity levels. Correlation between magnesium serum levels and severity of asthma was controversies. It might be influenced by race, genetic pattern, diet and demography factor.
Objective: The objective of this study was to know relationship between magnesium serum levels and predictive PEF (Peak Expiratory Flow) in chronic asthma patients in Yogyakarta.
Method: This was a cross-sectional study; subjects were asthma patients who visited Pulmonology Outpatient Department in Dr. Sardjito General Hospital Yogyakarta, from September 2004 - March 2005. We performed clinical evaluation, magnesium serum levels (normal 0.65 mmol/L-1.04 mmol/L), predictive PEF and medications. Correlation between magnesium serum levels and PEF were analyzed by Pearson correlation test. This study used analysis of variance (anova) to analyze mean difference among more than 2 groups and multiple regressions to know the variables which influenced serum magnesium levels.
Result: There were 62 asthma patients in this study. There was no hypomagnesaemia. The mean of magnesium was 0.89 ± 0.08 mmol/L. Results showed that serum magnesium levels and predictive PEF had weak correlation (r= 0.281; p=0.027). There was no significant correlation between admission rate to Emergency Room due to asthma by magnesium levels (r=0.029 p= 0.8).
Conclusion: Results showed weak relationship serum magnesium levels and PEF in chronic asthma patients.
Keywords: bronchial asthma; serum magnesium levels, Peak Expiratory Flow rate
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Global Initiative for Asthma (GINA), 2005, Global Strategy For Asthma Management and Prevention, National Instititute of Health. www.Ginasthma.com,
Sundaru, H. 2001, Asma Bronkial, in S. Suyono, , S. Waspadji., (eds) Buku Ajar Ilmu Penyakit Dalam, Balai Penerbit FKUI p. 21-32
Reinhart, R..A., 1988, Magnesium Metabolism: a Review with Special Reference to the Relationship Between Intracellular Content and Serum Level, Arch Internal Medicine 148:2415-2420
Spivey, W. H., Skobelpff, E. M, Levin R.M., 1984, Effect of Magnesium Chloride on Rabbit Bronchial smooth Muscle, Annual Emergency Medicine 19:1107-1112
Dominguez L.J, Barbagallo, M., Lorenzo, G. D., Drago A. et al., 1998, Bronchial Reactivity and Intracellular Magnesium: a Possible Mechanism for the Bronchodilating Effects of Magnesium in Asthma, Clinical Science 95: 137-142.
Fassler, C.A., Rodriguez, M., Badesch, D.B., Stone, W.J, Marini J.J , 1985, Magnesium toxicity as a Cause of Hypotension and Hypoventilation. Arch Internal Medicine 145, 1604-1606
Britton, J., Pavord, I., Richards, K., 1994, Dietary Magnesium, Lung function, Wheezing, and Airway Hypereactivity in a Random Adult Population Sample, Lancet 344: 357-62
Alamoudi, O. S, 2000, Hipomagnesemia in Chronic Stable Asthmatics: Prevalence, Correlation with Severity and Hospitality, Europe Respiratory Journal, 16: 427- 431
Alter H. J., Thomas D. K. Hilty W. M., 2000, Intravenous Magnesium as an Adjuvant in Acute Bronkospasme: A Meta Analysis, Annals of Emergency Medicine vol 36:191-197.
Ciarallo, L., Broisseau, D. Reinert, S., 2000, Higher Dose Intravenous Magnesium Therapy for Children with Moderate to Severe Acute Asthma, Arch Pediatric Adolescence Med ; 154 (10):979-83
Silverman R. A., Osborn H. Runge J., Gallagher E. J., 2002, IV Magnesium Sulfate in the Treatment of Acute Severe Asthma, a Multicenter Randomized Controlled Trial, CHEST, 22 : 489-497.
Ian J , Johnson K , Montelpare , McAuliffe, 2002, Variability within individuals of plasma ionic magnesium concentrations, BMC Physiology, 2:6 ,www.biomedcentral.com
National Asthma Education an Prevention Program.Expert (NAEPP) ,1997, Panel Report 2: guidelines for Diagnosis and Management of Asthma, Bethesda, MD: National Institutes of Health, in B.D. Rose (Eds), UpToDate version 14.1
Prasson J.,Mani S.K.,2003, Peak Expiratory Flow vs spirometry in Patients with Asthma, www.rcjournal.com
Alamoudi, O.S., 2001, Electrolyte Disturbance in Patients With Chronic, Stable Asthma, Chest 120:431-436
Agus, Z. A.,2005 1, Causes of Hypomagnesemia, dalam B.D Rose, UpToDate ed 14.1
Agus, Z. A.,2005 2, Causes and Treatment of Hypermagnesemia, dalam B.D Rose UpToDate ed 14.1
Agus, Z. A.,2005 3, Regulation of Magnesium Balance, dalam B.D Rose UpToDate ed 14.1
Zervas, E., Papatheodorou G., 2003, Reduced Intracelluler Mg Concentration in Patients With Acute Asthma, Chest:123:113-118
Cohen J, 1977, Statistical Power Analysis for the Behavioral Science, Academy Press, p. 93
DOI: https://doi.org/10.22146/acta%20interna.3866
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