Association between Zinc Serum Level And CD4+ Count In Healthy Elderly Women At AISYIAH Elderly Club Kota Gede Yogyakarta

Niko Adhi Husni(1*), Wasilah Rochmah(2), Suhardi Darmo Atmodjo(3)

(*) Corresponding Author



Introduction. Old ages are associated with physiologic deteriorations of all organs and tissues, such as involution of thymus and decreased function of gastrointestinal tract which lead to malnutrition. Involution of thymus will caused reduction of T cell subset for instance T cell CD4+. Prevalence of nutrient deficiency in old age was high, according to a survey that 35% of subjects with age above 50 years old showed deficiency for one or more vitamins and trace-elements. Zinc as one of trace-elements has vital role for immune system.

Aim. Aims of this study are to know the mean of zinc serum level, proportions of zinc deficiency in elderly and correlation between zinc and CD4+ count.

Methods and Subjects. Design of this study is cross sectional,  with study subjects including healthy elderly women from Aisyiah elderly club at Kota Gede Yogyakarta. Elderly who were eligible with study criteria were measured height, weight, zinc serum level, and CD4+ count. Correlation test was performed to know correlation between ages, weight, body mass index (BMI), and zinc serum level with CD4+ count. Significant variables will be tested with multiple linier regressions. Level of significance is p < 0.05.

Results. A total healthy elderly women subjects were 60 persons with median of age 63.5 years old. Median zinc serum level was 5.47 umol/L with range between 3.25-             7.95 umol/L. Zinc deficiency (zinc serum level < 7.65 umol/L) occured in 95% of subjects. Mean of CD4+ count was 767.22±232.95 count/mm3. There were correlations between age, weight, and zinc serum level with CD4+ count (r= -0.296; 0.345; 0.324; 0.792, respectively). Results from linear regression model showed zinc serum level was the only variable that affect to CD4+ count (adjusted R2 = 0.622).

Conclusion. Ninety five percent of healthy elderly women at elderly club Aisyiah Kota Gede Yogyakarta suffer from zinc deficiencies, and there is strong correlation between zinc serum level and CD4+ count.


Keyword: zinc serum, CD4+ count, elderly

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Strausbagh, L.J. Special issue: emerging health care-associated infection in the geriatric population. Emerg infect dis 2001; 7. 268-271.

Darmojo, R.B. Gangguan kesehatan dan penyakit pada usia lanjut: sehat sejahtera di hari tua Dalam Suhardjono (editor) Bunga rampai karangan ilmiah.. hal. 280-290. Semarang: Balai penerbit Universitas Diponegoro. 1996.

Rink, L. dan Seyfarth. M. Characteristic of immunologic test values in the elderly. Z Gerontol Geriatr 1997; 30. 220-225.

Soenarto. Rematik pada usia lanjut Dalam R.B. Darmojo. dan H.H. Martono (editor) Buku ajar usia lanjut (ilmu kesehatan usia lanjut) edisi kedua.. hal. 214-326. Jakarta: Balai penerbit Fakultas Kedokteran Universitas Indonesia. 2000.

Baratawidjaja, K.G. Defisiensi imun Dalam Imunologi dasar.. hal. 306-307. Jakarta: Balai penerbit Fakultas Kedokteran Universitas Indonesia. 2002.

Suhardjono dan Sari. N.K. Nutrisi optimal untuk pasien usia lanjut yang dirawat Dalam Pertemuan ilmiah tahunan perkembangan mutakhir ilmu penyakit dalam. Acta medica Indonesiana 2003; 35. 134S-138S.

Chandra, R.K. Nutrition and the immune system from birth to old age. Eur J Clin Nutr 2002; 56. S73-S76.

Goode, H.F. Naylor. J.R. dan Walker. B.E. Correction of cellular zinc depletion by oral zinc supplementation in elderly subjects. Clin Nutr 1993; 12. 29-32.

Isa, L. Luchini, A. Lodi. S. dan Giachetti, M. Blood zinc status and zinc treatment in human immunodeficiency virus-infected patients. Int J Clin Lab Res 1992; 22. 45-47.

Meerarani, P. Ramadass, P. Toborek, M. Bauer, H.C. Bauer. H. dan Hennig. B. Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor α. Am J Clin Nutr 2000; 71. 81-87.

Storandt, M. Phsychological aspects of aging Dalam I. Rossman (ed.) Clinical Geriatrics. 3rd ed.. pp. 606-655. Philadelphia: J.B. Lippincott Company. 1986.

Klapproth, J.M. dan Yang. V.W. Malabsorption Dalam T. Patel. F. Talavera. D.M. Heuman. A.J. Mechaber. dan J. Katz (editors) eMedicine 2007 [cited 2008Jan12]. Available from; URL:

Rochmah, W. Peranan nutrisi pada usia lanjut Dalam A.H. Asdie. dan R. Broto (eds) Naskah lengkap pertemuan ilmiah tahunan ilmu penyakit dalam Fakultas Kedokteran UGM.. hal. 68-72. Yogyakarta: Medika. 2000.

Keusch, G.T. Alpers. D.H. Stenson. W.F. dan Bier. D.M. The national institutes of health agenda for international research in micronutrient and infection interactions. J Infect Dis 2002; 182. S139-S142.

Daly, M.P. and Adelman. A.M. Nutritional status and involuntary weight loss. In: A.M. Adelman. M.P. Daly. and B.D. Weiss (editors) 20 COMMON PROBLEMS IN Geriatrics.. pp. 337-348. Boston: McGraw-Hill. 2001.

Reviana, Ch. 2004. Peranan mineral seng (zinc) bagi kesehatan tubuh. Cermin Dunia kedok 2004; 143. 53-54.

Weksler, M.E. Biological basic and clinical significance of immune senescence Dalam I. Rossman. (ed.) Clinical geriatrics 3rd ed.. pp. 57-67. Philadelphia: J.B. Lippincott Company. 1986.

Miller, R.A. The biology of aging and longevity Dalam W.R. Hazzard. E.L. Bierman. J.P. Blass. W.H. Ettinger Jr. dan J.B. Halter. (eds.). R. Andres. (ed. em.). Principles of geriatric medicine and gerontology 3rd ed. International ed.. pp. 3-16. New York: McGraw-Hill Inc. 1994.

Field, C.J. Johnson. I.R. dan Schley. P.D. Nutrients and their role in host resistance to infection. J Leukoc Biol 2002; 71. 16-32.

Moore, D.M. Awor. A. Downing. R.S. Were. W. Solberg. P. Tu. D. Chan. K. Hogg. R.S. dan Mermin. J. Determining eligibility for antiretroviral therapy in resource-limited settings using total lymphocyte counts. hemoglobin. and body mass index. AIDS Res Therapy 2007; 4. 1-7.

Lukito, W. Wattanapenpaiboon. N. Savige. G.S. Hutchinson. P. dan Wahlqvist. M.L. Nutritional indicators. peripheral blood lymphocyte subsets and survival in an institutionalized elderly population. Asia Pacific J Clin Nutr 2004; 13. 107-112.

Shankar, A.H. dan Prasad. A.S. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998; 68. 447S-463S.


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