Correlation Between C-Reactive Protein And Left Ventricular Ejection Fraction InN Anterior ST Elevation Myocardial Infarction

Rosa Priambodo(1*)

(*) Corresponding Author



Background:  C-Reactive  Protein (CRP)  levels  were  found  increase  in  ST  elevation myocardial  infarction (STEMI) patients, before and after STEMI. Increase of CRP levels were able to activate complement pathway to induce inflammation by attracting neutrophil and macrophage to enter to infarcted myocardial.  Infarct expansion followed by remodeling process, led to left ventricular dysfunction and decrease of ejection fraction.

Aim: This study aimed to investigate a correlation between CRP plasma levels and left ventricular ejection fraction (LVEF) in anterior STEMI patients.

Subject and method: This study was conducted cross-sectionally. Subjects were new anterior STEMI patients, with maximum onset of 48 hours. Exclusion criteria included  evidence of infection, inflammation, history of surgery or stroke in last three months, malignancy, congestive heart failure and inferior STEMI. There were 30 subjects who met  the eligible criteria. CRP blood samples were collected at least 48 hours after onset.  LVEF measurement was done during   hospitalization. The correlation between CRP levels and LVEF was analyzed by Spearman rank correlation test.

Result: CRP levels in female subjects were higher than males [CRP median 23.4 mg/l (5.73 – 61.4 mg/l) vs. 12. 2 mg/l (5.6 – 66.5 mg/l)], but with no significance (P= 0.297). The thrombolytic therapy group had lower CRP levels than non thrombolytic therapy group [10. 7 mg/l (5.6 – 44.5 mg/l) vs. 14.7 mg/l (8.7 – 66.5 mg/l), also with no significance (P= 0.178). There was a non-significantly negative correlation between CRP level and LVEF (r = - 0.100, P= 0.597).

Conclusion: There was no correlation between CRP level and LVEF in anterior STEMI.

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