Relationship Between Systemic Lupus Activity Measurement (SLAM) Score and Mortality in Systemic Lupus Erytemathosus (SLE) Inpatients

https://doi.org/10.22146/acta%20interna.5729

Ayu Paramaiswari(1*), Nyoman Kertia(2), Deddy Wachid Achadiyono(3)

(1) 
(2) 
(3) 
(*) Corresponding Author

Abstract


ABSTRACT
Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder that can be severe and life threatening. Mortality in SLE may due to lupus activity or long-term sequel. Systemic Lupus Activity Measurement (SLAM) score is a tool that can count lupus disease activity inpatients.
Aims: To analyze the relationship between SLAM score and mortality in lupus inpatients.
Methods: Retrospective cohort study used for reaching objective of the study. Lupus inpatients was used as research population. Medical record was used as study data collection over periods of 2006 until 2011. Independent variable was a SLAM score. The cut point of SLAM score was made based on the mean of SLAM score (16.7 point score). Dependent variable was mortality.
Results: There were differences between number of ACR criteria fi ndings, pneumonia, heart rate with SLAM score (p value 0.001; 0.001; 0.002 respectively).There was a difference of median survival between less and more than 16.7 point score, 45 and 28 respectively (p 0.034). There was a relationship between SLAM score (more than 16.7 point score) and mortality HR 2.78 (96% CI 1.01-7.53). There was a difference of mortality incidence between more and less than 16.7 point score, 0.35 and 0.10 respectively. There was a relationship between SLAM score (more than 16.7 point score) and mortality RR 3.5 (95% CI). Mortality in lupus inpatients was 23%.
Conclusion: There was a relationship between SLAM score and mortality on lupus inpatients.
Keywords: SLE, SLAM, Mortality


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References

REFERENCES

Kyttaris V, Katsiari C, Juang Y, Tsokos G (2005). New insight into the pathogenesis of systemic lupus erythematosus.Current Rheumatology Reports 7, 469-475.

Wu Y, Huang Z, Shi Y, Cai B, Wang L, Ying B, Hu C, Li Y, Liang W (2009). Systemic lupus erythematosus (SLE) risk factors: Novel proteins detected from familial SLE using proteomics. Labmedicine 40 (7), 408-4011.

Bernatsky S et al (2006). Mortality in Systemic Lupus Erithematosus.Arthritis & Rheumatism 54, 2550-2557.

Lopez R, Davidson J, Beeby M, Egger P, Isenberg D (2012). Lupus disease activity and the risk of subsequent organ damage and mortality in large lupus cohort. Rheumatology 51, 491-498.

Bae SC, Koh HK, Chang DK, Kim MH, Park JK, Kim SY (2001). Reliability and validity of systemic lupus measure-revised (SLAM-R) for measuring clinical disease activity in systemic lupus erythematosus. Lupus 10, 405-409.

Lam GKW, Petri M (2005). Assessment of systemic lupus erythematosus.Clin Exp Rheumatol 23 (Suppl.39).S120-S132.

Romero-Diaz J, Isenberg D, Ramsey- Goldman R (2011). Measures of adult systemic lupus erythematosus.Arthritis Care & Research 63 (S11), S37-S46.

Nacach AZ, Yanez P, Jimenez-Balderas FJ, Camargo-Coronel A (2007).Disease Activity, damage, and survival in Mexican patients with acute severe systemic lupus erithematosus.Lupus 16, 997-1000.

Calvo-alen J, Reveille JD, Rodrigues- Valverde V, McGwin G, Baethge BA, Friedman AW, Alarcon GS (2003). Clinical, immunogenetic and outcome features of Hispanic systemic lupus erythemoatosus patients of different ethnic ancestry Lupus12, 377-385

Apte M, McGwin G, Vila L, Kaslow R, Alarcon G, Reveille J (2008).Associated factors and impact of myocarditis in patients with SLE from LUMINA, a multiethnic US cohort.Rheumatology (47), 362-367.

Teh CL, Ling GR (2013). Causes and predictors of mortality in hospitalized lupus patient in Sarawak General Hospital, Malaysia. Lupus 22, 106-111.



DOI: https://doi.org/10.22146/acta%20interna.5729

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