The Correlation between Thyroid Hormone Levels with Functional Mobility Performance among the Geriatric Patients in Dr. Sardjito General Hospital
Henny Rumaropen(1*), M Robikhul Ikhsan(2), Raden Bowo Pramono(3)
(1) 
(2) 
(3) 
(*) Corresponding Author
Abstract
Background. Alteration of the endocrine system in the elderly people may be caused by changes in secreted hormone levels or decreased sensitivity of target organs. These changes also apply to thyroid function, which can cause disability, cognitive impairment, cardiovascular risk, and decreased muscle mass and strength in the elderly. Physiologically, there are several changes in the concentration of thyroid hormone Concentrations due to aging process, such as reduced TSH (Thyroid Stimulating Hormone), total T3 (Triiodothyronine) and free T levels, and increased rT3 (Reverse triiodothyronine), which is an inactive T (Thyroxine) metabolite in the serum. Even so,the free T4 and the total T44 remain unchanged, except for the sick. As a result, proper diagnosis and management are expected to minimize the deprivation experienced by the subjects due to a decrease in functional mobility.
Aims. The aim of the study was to assess the correlation between the levels of thyroid hormones and functional mobility among the elderly at Dr. Sardjito General Hospital, Yogyakarta.
Method. Observational descriptive and analytical study with cross-section design was performed. Subjects were recruited used a consecutive sampling method for subjects who met the inclusion and exclusion criteria. The statistical analysis used to find a correlation between the levels of the thyroid hormone and the performance of the functional mobility by Pearson Correlation test. Here the study used Spearman Correlation test if the conditions were not met the criteria. Significance limit with p < 0.05.
Results. A total of 36 research subjects who met the inclusion and exclusion criteria. The mean age was 69.67±6.164 years. Consisted of 16 (44.4%) male and 20 (55.6%) were female. The median of TSH (Thyroid Stimulating Hormone) was 1.170 (0.19-3.64) μIU/mL and the median free T was 1.280 (0.80-2.34) ng/dL. TSH level in male was more than female with same time in gait speed. The male median TSH level was 1.370 (0.60-3.64) μIU/mL and women 0.980 (0.19-3.17) μIU/mL. Slow gait speed more than thirty second (high risk of falling), the TSH mean in mas was 2.690 μIU/mL and women 1.150 μIU/mL. The test results indicate thyroid hormone level has no significant effect on functional mobility performance (timed up and go test score) in the elderly subjects (p value=0.531) and with level Free T4 (p value=0.721).
Conclusion: In this study population, thyroid hormones did not have a statistically significant correlation with functional mobility in the elderly. Males with higher serum levels and females with lower serum TSH (Thyroid Stimulating Hormone) were at increased risk of frailty.
Keywords
Full Text:
PDFReferences
References
Ceresini G, Ceda GP, Lauretani F, Maggio M, Bandinelli S, Guralnik JM, et al., 2011. Mild Tyroid Hormone Excess is Associated with a Decreased Physical Function in Elderly Men. Aging Male. 14: 213 - 9.
Van Den Beld AW, Visser TJ, Feelders RA, Grobbee De, Lambert SWJ., 2005. Thyroid Hormone Concentration, Disease, Physical Function, and Mortality in Elderly Men. J Clin Endocrinol Metab. 90:6403-9
Darmojo RB, Martono HH, Geriatri (Ilmu Kesehatan Usia Lanjut). Balai Penerbit FKUI. Jakarta.2000.
HA Bischoff, Stahelin HB, Andreas UM, Maura DI. Identifying Cut Off Point for Normal Mobility: Comparison of The Time “Up and Go” Test In Community Dwelling and Institutionalized Elderly Woman. In: Age and Ageing.British Geriatrics Society.2003;32 315-20
Shoba S. Preventing of Falls in Older Patients. Accessed online January 20, 2007, at: http://www.aafp.org/afp/20050701/81.
html
Setiati S, Laksmi PW. Gangguan Keseimbangan, Jatuh dan Fraktur. Di dalam: Sudoyo AW, Setyohadi B, Alwi I, dkk, ed. Buku Ajar Ilmu Penyakit Dalam.Edisi ke-4. Pusat Penerbitan Departemen Ilmu Penyakit Dalam FK-UI. Jakarta.2006. 1388-97
Wall JC. The Timed Get-up and Go Test Revisited: Measurement of the component Task. Journal of rehabilitation Research & Development 2000; 37: 109-114
Yeap BB, Alfonso H, Chubb SAP, et al. Higher free thyroxine levels are associated with frailty in older men: The Health in Men Study. Clin Endoc
Ajish, T.P., Jayakumar, R.V., 2012. Geriatric Thyroidology: An Update. Indian Journal of Endocrinology and Metabolism. Volume 16(4).rinol (Oxf) 2012;76: 741–748
Annewieke W. van den Beld, Theo J. Visser, Richard A. Feelders, Diederick E. Grobbee,and Steven W. J. Lamberts. 2005. Thyroid Hormone Concentrations, Disease, Physica Function, and Mortality in Elderly Men. The Journal of Clinical Endocrinology & Metabolism 90(12):6403–6409
Jacobs, M., Fox, T, 2008. Using The “Timed Up and Go/ TUG” Test to Predict Risk of Falls; from http://www.assistedlivingconsult.com/issues/.(Accesed
July 2010)
Podsiadlo, D., Richardson, S., “The Time Up and Go Test: A Test of Basic Functional Mobility for Frail Elderly Persons”, Journal American Geriatrics Society. Vol.39, 1991.
Virgini VS, Rodondi N, Cawthon PM, etal. Subclinical thyroid dysfunction, and frailty among older men. J Clin Endocrinol Metab 2015; 100:4524–4532
DOI: https://doi.org/10.22146/actainterna.61290
Article Metrics
Abstract views : 1381 | views : 1275Refbacks
- There are currently no refbacks.
Copyright (c) 2020 Acta Interna: The Journal of Internal Medicine
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Acta Interna The Journal of Internal Medicine Indexed by:
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.