Swamedikasi diabetes mellitus dengan daun ceplikan (Ruellia tuberosa L.): kajian kemanfaatan pada profil lipid serum secara praklinik
Ety Yuni Ristanti(1*), Wiryatun Lestariana(2), Lily Arsanti Lestari(3)
(1) Politeknik Kesehatan Departemen Kesehatan RI Maluku
(2) Bagian Biokimia Faluktas Kedokteran Universitas Gadjah Mada
(3) Program Studi Gizi Kesehatan Universitas Gadjah Mada
(*) Corresponding Author
Abstract
Background: Self-medication by using ceplikan leaves (Ruellia tuberosa L.) has been practiced in society for many times in the after-boiled form. It had been proved that liquid extract of ceplikan leaves (Ruellia tuberosa L.) was able to reduce blood glucose level on diabetic rat. It is also well known among diabetes mellitus patient that it has following effect on increasing triglyceride and reducing HDL-cholesterol level.
Objective: This research was aimed to give scientific evidence on the society habit on self-medication by using ceplikan leaves (Ruellia tuberosa L.) by examining its oral administration on serum lipid profile pre-clinically.
Method: Two months old Rattus novergicus within average weight of 150-200 g were divided into experimental and control groups. The control group consisted of 6 normal rats; while the experimental group consisted of 24 alloxan induced-diabetic rats. The experimental groups were divided into four groups i.e. non-treatment group and oral administrations of Ruellia tuberosa L. liquid extract with different concentrations that were 1.6 mg, 3.2 mg, and 6.4 mg, respectively. The feeds were given ad libitum. The oral administrations of Ruellia tuberosa L. liquid extract were given everyday for 30 days. In the end of the treatment, all rats were fastened and the blood was taken from the eye and being observed for its serum lipid profile. The data were analyzed statistically by using ANOVA and Tukey’s HSD mean difference tests.
Results: The results showed that oral administration of 3.2 mg Ruellia tuberosa L. liquid extract was significantly reduced triglyceride and LDL-cholesterol level (p < 0,05) and increased HDL-cholesterol level (p < 0,05).
Conclusion: The 3.2 mg of Ruellia tuberosa L. liquid extract was able to reduce triglyceride and LDL-cholesterol level and increase HDL-cholesterol level. Moreover, ceplikan leaves (Ruellia tuberose L.) could be taken as traditional drugs in a non-formal way with control on dietary intake and regular physical exercise.
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Asdie AH. Patogenesis dan Terapi Diabetes Mellitus Tipe 2. Yogyakarta: Medika FK UGM; 2000.
Waspadji S. Diabetes Mellitus: Mekanisme Dasar dan Pengelolaan yang Rasional dalam Penatalaksanaan Diabetes Mellitus Terpadu. Jakarta: Pusat Diabetes dan Lipid RSUP Nasional RSCM dan FKUI; 2005. p. 21-32.
Goldberg Jl. Diabetic Dyslipidemia: Causes and Consequences. J Clin Endocrinol Metab 2001;86(3):956-71.
Trivedi NA, Mazumdar B, Bhatt JD, Hemavathi KG. Effect of Shilajit on Blood Glucose and Lipid profile in Alloxan Induced Diabetic Rats. Indian J Pharmacol 2004;36(6):373-6.
Hussein HM, El-Sayed EM, Said AA. Antihyperglycemic, Antihiperlipidemic and Antioxidant Effect of Zizyphus spina christi and Zizyphus jujuba in Alloxan Diabetic Rats. Int J Pharmacol 2006;2(5):563–70.
Tandri TH. Pengaruh Pemberian Ekstrak Air Daun Ceplikan (Ruellia tuberosa L.) terhadap Kadar Glukosa Darah dan Gambaran Histologis Sel Beta Pankreas pada Tikus Putih (Rattus norvegicus) Diabetes Melitus [tesis]. Yogyakarta: Universitas Gadjah Mada; 2008.
Fwu Lin C, Ling Huang Y, Ying Cheng L, Jyi Sheu S, Chih Chen C. Bioactive Flavonoid from Ruellia tuberosa L. J Chin Med 2006;17(3):103-9.
Li M, Qu W, Wang Y, Wan H, Tian C. Hypoglycemic Effect of Saponin from Tribulus terrestris. Zhong Yao Cai 2002;25(6):420-2.
Anief M. Ilmu Meracik Obat Teori dan Praktik. Yogyakarta: Gadjah Mada University Press; 1999.
Perkeni. Konsensus Pengelolaan Diabetes Melitus Tipe 2 Di Indonesia. Jakarta: PB Perkeni; 2006.
Suyono S. Patofisiologi Diabetes Mellitus. In: Soegondo S, Soewondo P, Subekti I, editors. Penatalaksanaan Diabetes Mellitus Terpadu. Jakarta: Pusat Diabetes dan Lipid RSUP Nasional RSCM dan FKUI Bekerja Sama dengan Departemen Kesehatan RI dan WHO; 2005. p. 5-10.
Sreemantula S, Kilari EK, Vardhan VA, Jaladi R. Influence of Antioxidant (L-ascorbic acid) on Tolbutamide Induced Hypoglycaemia/Antihyperglycaemia in Normal and Diabetic Rats. BMC Endocr Disord 2005; 5(2): 1-5.
Yassin MM, Mwafy SN. Protective Potential of Glimepirid and Nerium Oelander Exctract on Lipid Profile, Body Growth Rate, and Renal Function in Streptozotocin Induced Diabetic Rats. Turk J Biol 2007;31:95–102.
Li Xue W, She Li X, Zhang J, Hui Liu Y, Lun Wang Z, Juan Zhang R. Effect of Trigonella foenum-graecum (fenugreek) Extract on Blood Glucose, Blood Lipid and Hemorheological Properties in Streptozotocin-Induced Diabetic Rats. Asia Pac J Clin Nutr 2007;16(Suppl I): 422-6.
Budiyanto MAK. Dasar-Dasar Ilmu Gizi. Malang: Universitas Muhammadiyah Malang; 2004.
Miller A L. Antioxidant Flavonoid: Structure, Function and Clinical Usage. Altern Med Rev 1996;1(2):103–11.
Winarsi H. Isoflavon sebagai Sumber, Sifat dan Manfaatnya Pada Penyakit Degeneratif. Yogyakarta: Gadjah Mada University Press; 2005.
Almatsier S. Prinsip Dasar Gizi. Jakarta: PT Gramedia Pustaka Utama; 2003
DOI: https://doi.org/10.22146/ijcn.17569
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