Pengaruh ekstrak melon terhadap kadar HbCO pada tikus Wistar jantan yang dipapar asap rokok

https://doi.org/10.22146/ijcn.17832

Yuyun Erlina Susanti(1*), Bambang Wirjatmadi(2), Merryana Adriani(3)

(1) Fakultas Kesehatan Masyarakat, Universitas Airlangga Surabaya
(2) Departemen Gizi Masyarakat, Fakultas Kesehatan Masyarakat Universitas Airlangga
(3) Departemen Gizi Masyarakat, Fakultas Kesehatan Masyarakat Universitas Airlangga
(*) Corresponding Author

Abstract


Background: Smoking is something that is usual for most Indonesian society, especially adult males. According to Riskesdas, smoking behavior of the population trends to increase. A previous study suggested that exposure to cigarette smoke produce CO bond to hemoglobin. Melon (Cucumis melo) contains antioxidants that prevent tissue damage.

Objective: Analyze differences in levels HbCO Wistar male rats in treated and untreated extracts of melon.

Method: The research was a laboratory experiment with the post test control group design and complete random design. The subjects were 25 male Wistar rats aged 3 months. Subjects were divided into 5 groups and each group received treatment for 28 days. Data of level HbCO was collected and analyzed by Anova One Way test at 95% confidence level.

Results: The results showed a difference between the average levels of HbCO male Wistar rats (p value=0,000) treated and untreated extracts of melon.

Conclusion: Melon extracts effect on decreasing the levels of HbCO due to exposure to cigarette smoke. There were differences in levels of male Wistar rats HbCO on treated and untreated extracts of melon and be given at a dose of 250 IU/day.


Keywords


HbCO; melon extract; smoke

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References

  1. Trixie S, Amalia R. Perilaku merokok di kalangan mahasiswa Universitas Muhammadiyah Semarang. Prosiding Seminar Nasional Unimus 2010. Jurnal Unimus 2010;2(1):172-80.
  2. WHO. Global youth tobacco survey. [series online] 2014 [cited 2016 Jan 1]. Available from: URL: http://www.who.int/tobacco/surveillance/survey/gyts/country_reports.
  3. West, John B. Patofisiologi paru esensial, edisi 6. Jakarta: EGC; 2010.
  4. Amin M. Pemeriksaan dan interpretasi faal paru. PKB Pulmonologi dan Ilmu Kedokteran Respirasi Surabaya. Surabaya: FK Unair; 2013.
  5. WHO. Global adult tobacco survey. [series online] 2011 [cited 2016 Jan 1]. Available from: URL: http://www.who.int/tobacco/surveillance/survey/gats/en/.
  6. Luchese C, Simone P, Nogueira CW. Brain and lungs of rats differently affected by cigarette smoke exposure: antioxidant effect of an organoselenium compound. Pharmacol Res 2009;59(3):194-201.
  7. Wolfgang D, Karl O, Wilfried R. Oxidative stress and free radicals in COPD – implications andrelevance for treatment. Int Journal Chron Obstruct Pulmon Dis 2014;9:1207-24.
  8. Winarsi H. Antioksidan alami dan radikal bebas. Potensi dan aplikasinya dalam kesehatan. Yogyakarta: Penerbit Kanisius; 2007.
  9. Wirakusumah ES. Buah dan sayur untuk terapi. Jakarta: Penebar Swadaya; 2006.
  10. Olivia F, Alam S, Hadibroto I. Seluk beluk food suplement. Jakarta: PT Gramedia Pustaka Utama; 2014.
  11. Romao S. Theraupetic value of oral suplementation with melon superoxide dismutase and wheat gliadin combination. Nutrition 2015;31(3):430-6.
  12. Frank SB, Samuel SV, Karla MPP, Lanzetti M, Pimenta WA, Zin WA, et al. Long-term exposure to cigarette smoke impairs lung function and increase HMGB-1 expression in mice. Respir Physiol Neurobiol 2011;177(2):120-6.
  13. Harlev A, Ashok A, Sezgin OG, Amit S, Stefan SP. Smoking and male infertility: an evidence-based review. World J Mens Health 2015:33(3): 143-60.
  14. Kocyigit A, Erel O, Gur S. Effects of tobacco smoking on plasma selenium, zinc, copper and iron concentrations andrelated antioxidative enzyme activities. Clin Biochem 2001;34(8):629-33.
  15. Soemirat JD, Roosmini, Indah RS, Khatarina O. Toksikologi lingkungan. Yogyakarta: Gajah Mada University Press; 2009.
  16. ATSDR. Toxicological profile for carbon monoxide poisoning. [series online] 2016 [cited 2016 Mar 1]. Available from: URL: https://www.atsdr.cdc.gov/ToxProfiles/index.asp.
  17. Renard D, Robert P, Lavenant L, Melcion D, Popineau Y, Schmitt C, et al. Biopolymericcolloidal carriers for encapsulation or controlled release applications. Int J Pharm 2002;242(1-2):163-6.
  18. Mauguet MC, Legrand J, Brujes L, Carnelle G, Larre C, Popineau Y. Gliadin matrix for microencapsulation processes by simplecoacervation method. J Microencapsul 2002;19(3):377-84.
  19. Ezpeleta I, Arangoa MA, Irache JM, Stainmesse S, Chabenet C, Orecchioni AM. Preparation of ulex europaeuslectin-gliadin nanoparticle conjugates and their interaction with gastrointestinalmucus. Int J Pharm 1999;191(1):25-32.
  20. Fassano A, Not T, Wang W, Uzzau S, Berti I, Goldblum SE. Zonulin, a newly discovered modulator of in-testinal permeability, and its expression in celiac disease. Lancet 2000;355(9214):1518-9.
  21. Calderon DB, Yepiz-Plascencia, Bøg-Hanse N. Hydrophobic interactions between gliadin and proteins and celiac disease. Life Sci 1996;59(23):1951-60.



DOI: https://doi.org/10.22146/ijcn.17832

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