Peranan kadar nitrit oksida (NO) darah dan asupan lemak pada pasien hipertensi dan tidak hipertensi

https://doi.org/10.22146/ijcn.18847

Pudji Astutik(1*), Bambang Wirjatmadi(2), Merryana Adriani(3)

(1) Program Magister Fakultas Kesehatan Masyarakat Universitas Airlangga Surabaya
(2) Fakultas Kesehatan Masyarakat Universitas Airlangga Surabaya
(3) Fakultas Kesehatan Masyarakat Universitas Airlangga Surabaya
(*) Corresponding Author

Abstract


Background: Hypertension is closely related to impaired endothelial dependent vasodilation due to decreasing availability of blood nitric oxide (NO) and high fat intake.

Objective: To analyze blood NO and fat intake differences in patients with hypertension andnon hypertension.

Method: The study was a cross-sectional design and sampling was carried out in Sidoarjo District Hospital. Subjects of the study were 24 patients aged between 40 to 65 years, which consist of 12 cases and 12 controls. Measurement of blood NO and recall of fat intake were performed.

Results: Blood NO in hypertension andnon hypertension patients were 72.333 ± 40.511µM and 116.083 ± 46.962 µM respectively. Fat consumption in hypertension andnon hypertension were 51.52 ± 5.99 g and 41.65 ± 8.32 g respectively. Two independent samples t-test showed meaningful differences in the levels of blood NO (p=0.023) as well as fat intake (p=0.004) between the hypertension andnon hypertension patients.

Conclusion: There is a difference in the levels of blood NO and fat intake in patients with hypertension andnon hypertension.


Keywords


hypertension; nitric oxide; fat consumption level

Full Text:

PDF


References

Surkesnas. Laporan survei kesehatan rumah tangga (SKRT), studi morbiditas dan disabilitas. Jakarta: Badan Penelitian dan Pengembangan Kesehatan, Departemen Kesehatan; 2004.

Yogiantoro M. Hipertensi esensial dalam buku ajar ilmu penyakit dalam jilid I edisi IV. Jakarta: Fakultas Kedokteran Universitas Indonesia; 2006.

Badan Penelitian dan Pengembangan. Survei nasional (Surkesnas) 2004: SKRT 2004 - vol 2: status kesehatan masyarakat Indonesia. Jakarta: Badan Penelitian dan Pengembangan Kesehatan; 2005.

Kemenkes RI. Profil kesehatan Indonesia 2010. Jakarta: Kemenkes RI; 2011.

Yundini. Faktor resiko hipertensi. Jakarta: Warta Pengendalian Penyakit tidak Menular; 2006.

Rohman SD. Oxidative stress and cardiovascular injury. Dalam Kumpulan Makalah PIT Nasional IV PDS PATKLIN; 2005 Nov 25-27; Malang.

Haris S, Tambunan T. Hipertensi pada sindrom metabolik. Sari Pediatri 2009;11(4):257-63.

Torrance B, McGuire KA, Lewanczuk R, McGavock J. Overweight, physical activity and high blood pressure in children: a review of the literature. Vasc Health Risk Manag 2007;3(1):139-49.

Setiati. Buku ajar ilmu penyakit dalam jilid III. Jakarta: Pusat Penerbitan Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia; 2006.

Hartanto. Patofisiologis: konsep klinis proses-proses penyakit edisi 6. Jakarta: EGC; 2005.

Kuntoro. Metode sampling dan penentuan besar sampel. Surabaya: Pustaka Melati; 2010.

Slamet S, Rossa E. Peran F2-isoprostan dan nitrik oksida sebagai penanda stres oksidatif dan disfungsi endotel pada penderita preeklamsi. Jurnal Kesehatan Masyarakat 2007;7(1):47-54.

Tyagi N, Sedoris KC, Steed M, Ovechkin AV, Moshal KS, Tyagi SC. Mechanisms of homocysteine induced oxidative stress. Am J Physiol Heart Circ Physiol 2005;289(6):2649-56.

Ikrar T. Nitric oxide berperan dalam pencegahan dan penyembuhan penyakit jantung dan pembuluh darah. [series online] 2012 [cited 2013 Jan 7]. Available from: URL: http.//kabarinews.com/nitric-oxide-berperan-dalam-pencegahan-dan-penyembuhan-penyakit-jantung-dan-pembuluh-darah/49513

Taniyama Y, Griendling KK. Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension 2003;42(6):1075-81.

Martalina KT, Sulchan M. Hight fat intake and sport activity as risk factors of obesity hypertension in early adolescence. Journal of Nutrition Collage 2012;1:169-78.

Wang Y, Lobstein T. Worldwife trends in childood overweight on obesity. Int J Pediatr Obes 2006;1(1):11-25.

Chao CL, Kuo TL, Lee YT. Effect of methionine-induced hyperhomosistein on endothelium-dependent vasodilatation and oxidative status in healthy adults. Circulation 2010;101(5):485-90.

Taddei S, Virdis A, Ghiadoni L, Salvetti G, Salvetti A. Endothelial dysfunction in hypertension. J Nephrol 2000;13(3):205-10.

Sugiarto A. Faktor-faktor resiko hipertensi grade II pada masyarakat (studi kasus di Kabupaten Karanganyar) [Tesis]. Semarang: Universitas Diponegoro; 2007.

Manurung E. Hubungan antara asupan asam lemak tak jenuh tunggal dengan kadar kolestrol HDL plasma penderita penyakit jantung koroner [Tesis]. Jakarta: Program Magister Sains Ilmu Gizi Klinik Universitas Indonesia; 2004.

Farketich. Links among depression, race hipertension, and the heart. USA: J. Clins Hypertens 2 (6) Le Jacq Communications; 2005.



DOI: https://doi.org/10.22146/ijcn.18847

Article Metrics

Abstract views : 7611 | views : 11869

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 Jurnal Gizi Klinik Indonesia (The Indonesian Journal of Clinical Nutrition)

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Gizi Klinik Indonesia (JGKI) Indexed by:
 
  

  free
web stats View My Stats