Pengaruh pemberian yogurt sinbiotik tepung pisang tanduk terhadap profil lipid tikus sindrom metabolik

https://doi.org/10.22146/ijcn.19369

Zana Fitriana Octavia(1*), Kis Djamiatun(2), Nyoman Suci(3)

(1) Program Studi Magister Ilmu Gizi, Fakultas Kedokteran Universitas Diponegoro
(2) Bagian Biomedik, Fakultas Kedokteran Universitas Diponegoro
(3) Bagian Patologi Klinik, Fakultas Kedokteran Universitas Diponegoro / Rumah Sakit Umum Pusat Dr. Karyadi
(*) Corresponding Author

Abstract


Background: The metabolic syndrome, which is characterized by hyperglycemia, obesity, dyslipidemia, hypertension, prothrombic and proinflamatory state, is a risk factor for cardiovascular disease and diabetes mellitus. The synbiotic yogurt of tanduk banana (Musa paradisiaca fa. corniculata) flour contains lactic acid bacteria, fructooligosaccarides, flavonoids, and vitamin C which all of them play role in improving the lipid profile.

Objective: The aim of this study was to prove the effect of synbiotic yogurt of tanduk banana flour on lipid profile of metabolic syndrome rats.

Method: This study was an true experimental with pre-post test  control group design. The subject of this study were 18 metabolic syndrome male Wistar rats divided into 3 groups,i.e control group (standart diet), intervention group I (standart diet and synbiotic yogurt of banana flour 0,009 ml/g weight/day), and intervention group II (standart diet and synbiotic yogurt of banana flour 0,018 ml/g weight/day). The intervention period was 2 weeks. Different test before and after intervention used paired t-test. The difference test between groups used One-Way ANOVA and Kruskal wallis.

Results: The result showed that both of intervention group improved lipid profile significantly (p<0,05). The intervention group II showed more effective improvement of lipid profile significantly (p<0,05) than intervention group I. The intervention group II decreased triglycerides level 41,56%; total cholesterol level 41,39%; LDL-cholesterol level 57,5%; and increased HDL-cholesterol level 139,62%.

Conclucion: The intervention of synbiotic yogurt of  tanduk banana flour can decrease triglyceride level, total cholesterol level, LDL-cholesterol level, and increase HDL-cholesterol level.


Keywords


lipid profile; metabolic syndrome; synbiotic; wistar rats; yogurt

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References

  1. International Diabetes Federation. The IDF concencus worldwide definition of the metabolic syndrome. Journal American Medical Association 2006;213(12):1345-52.
  2. Adult Treatment Panel III. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Journal American Medical Association 2001;285(16):2486-96.
  3. World Health Organization. Obesity: preventing and managing the global epidemic. Geneva: WHO; 2000.
  4. Ford ES, Gilles WH, Mokdad AH. Increasing prevalence of the metabolic syndrome among US adults. Diabetes Care 2004; 27:2444–9.
  5. Soewondo P, Purnamasari D, Oemardi M, Soegondo S. Prevalence of Metabolic Syndrome Using NCEP/ATP III Criteria in Jakarta, Indonesia: The Jakarta Primary Non-communicable Disease Risk Factors Surveillance 2006. J Intern Med. 2010; 42(4): 199-203.
  6. Varady KA, Jones PJH. Combination Diet and Exercise Inteventions for The Treatment of Dyslipidemia: An Effective Preliminary Strategy to Lower Cholesterol Levels. J Nutr. 2005;135:1829-35.
  7. Schrezenmeir J, de Vrese M. Probiotics, Prebiotics, and Synbiotics-Approaching: A Definition. Am J Clin Nutr. 2001; 73S: 361S-4S.
  8. Standar Nasional Indonesia. Yogurt. ICS 67.100.10. SNI 2981; 2009.
  9. FAO/WHO: Evaluation of Health and Nutritional Properties in Food Including Powder Milk with Live Lactic Acid Bacteria. In Expert Consultation Report. Cordoba: World Health Organization of United Nations; 2011.p.1-56.
  10. Gustaw W, Wiater MK, Koziol J. The Influence of Selected Prebiotics on The Growth of Lactic Acid Bacteria for Bio-Yoghurt Production. Acta Sci Pol Technol Aliment. 2011; 10(4): 455-66.
  11. Jenie BSL, Widowati S, Nurjanah S. Pengembangan Produk Tepung Pisang dengan Indeks Glikemik Rendah dan Sifat Prebiotik Sebagai Bahan Pangan Fungsional. Jurnal Teknologi dan Ilmu Pangan Institut Pertanian Bogor. 2009;1-3.
  12. Karlina R, Rahayuni A. Potensi Yogurt Tanpa Lemak dengan Penambahan Tepung Pisang dan Tepung Gembili Sebagai Alternatif Menurunkan Kolesterol. Jurnal of Nutrition College. 2014; 610:1-25.
  13. Costa GT, de Abreu GC, Guimarães ABB, de Vasconcelos PRL, Guimaraes SB. Fructo­oligosaccharide Effects on Serum Cholesterol Levels: An Overview. Acta Cirúrgica Brasileira. 2015; 30(5): 366-70.
  14. Ooi LG, Liong MT. Cholesterol-Lowering Effects of Probiotics and Prebiotics: A Review of in Vivo and in Vitro Findings. Int J Mol Sci. 2010; 11: 2499-522.
  15. Roselino MN, Pauly-Silveira ND, Cavallini DCU, Celiberto LS, Pinto RA, Vendramini RC, et al. A potential synbiotic product improves the lipid profile of diabetic rats. Lipids Health Dis 2012;11(114):1-9.
  16. Moroti C, Magri LFS, Costa MDR, Cavalini DCU, Sivleri K. Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus. Lipids Health Dis 2012;11(29):1-8.
  17. World Health Organization (WHO). General Guidelines for Metodologies on Research and Evaluation of Traditional Medicine. Geneva : WHO; 2001. p.1-71
  18. Muflikhatur S, Murwani H. Perbedaan pengaruh antara ekstrak dan rebusan daun salam (Eugenia polyantha) dalam pencegahan peningkatan kadar kolesterol total pada tikus Sprague Dawley. Journal of Nutrition College 2014;3(1):142-9.
  19. Ratnawati H, Widowati W. Anticholesterol Activity of Velvet Bean (Mucuna Pruriens L.) towards Hypercholesterolemic Rats. Sains Malaysiana. 2011; 40(4): 317-21.
  20. Yuniastuti A. Pengaruh Pemberian Susu Fermentasi Lactobacillus casei Strain Shirota Terhadap Perubahan Kadar Fraksi Lipid Serum Tikus Hiperkolesterolemia. Jurnal of Nutrition College. 2004; 1-96
  21. Nikjooy S, Hashemi S. Study The Possibility of Producing Symbiotic Yogurt Containing Lactobacillus casei and Wild Thyme Extract. International Journal of Agriculture and Crop Sciences 2015; 8(1): 61-7.
  22. Ratnawati H, Widowati W. Anticholesterol Activity of Velvet Bean (Mucuna Pruriens L.) towards Hypercholesterolemic Rats. Sains Malaysiana 2011; 40(4): 317-21.
  23. Crescenzo R, Bianco F, Coppola P, Mazzoli A,Tussellino M, Carotenuto R, et al. Fructose Supplementation Worsens The Deleterious Effects of Short-Term High-Fat Feeding on Hepatic Steatosis and Lipid Metabolism in Adult Rats. Exp Physiol 2014:99(9): 1203–13.
  24. Tsalissavrina I, Wahono D, Handayani D. Pengaruh Pemberian Diet Tinggi Karbohidrat dibandingkan Diet Tinggi Lemak Terhadap Kadar Trigliserida dan HDL Darah pada Rattus novergicus galur wistar. Ilmu Gizi Kesehatan Fakultas Kedokteran Universitas Brawijaya. Jurnal Kedokteran Brawijaya. 2006; 22(2): 80-9.
  25. Prahastuti S. Konsumsi Fruktosa Berlebihan dapat Berdampak Buruk bagi Kesehatan Manusia. JKM 2011;10(2): 173-89.
  26. Ramasamy K, Shafawi ZM, Mani V, Wan HY, Majeed ABA. Hypocholesterolaemic Effects of Probiotics. Intech. 2012; 163-80.
  27. Lye HS, Rusul G, Liong MT. Removal of Cholesterol by Lactobacilli via Incorporation of and Conversion to Coprostanol. J Dairy Sci. 2010; 93: 1383-92.
  28. Khamisy AESE. Effect of Bifidobacterium and Lactobacillus acidophilus in Diabetic Rats. In The 5th Arab and 2nd International: Annual Scientific Conference. Egypt: Faculty Specific Education - Mansoura University. 2010; 2425–39.
  29. Scavuzzi BM, Henrique FC, Miglioranza LHS, Simão ANC, Dichi I. Impact of Prebiotics, Probiotics and Synbiotics on Components of the Metabolic Syndrome. Ann Nutr Disord & Ther. 2014;1(2):1-13.
  30. Aguilar HM, Baez DA, Estrada MJ, Guererro GM, Bautista RJH, Alarcón-Aguilar FJ, et al. Effect of fructooligosaccharides fraction from Psacalium decompositum on inflammation and dyslipidemia in rats with fructose-induced obesity. Nutrients 2014;6(2):591-604.
  31. McRae MP. Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials. Journal of Chiropractic Medicine 2008; 7: 48–58.
  32. Kasolo JN, Bimenya GS, Ojok L, Ochieng J, Ogwal-Okeng JW. Phytochemicals and Uses of Moringa oleifera Leaves in Ugandan Rural Communities. Journal of Medicinal Plants Research 2010; 4(9): 753-57.



DOI: https://doi.org/10.22146/ijcn.19369

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