Pengaruh ekstrak teh hijau (Camellia sinensis) terhadap kadar malondialdehid (MDA) plasma dan kekuatan genggam tangan lanjut usia

https://doi.org/10.22146/ijcn.22833

Fera Nofiartika(1*), Susetyowati Susetyowati(2), I Dewa Putu Pramantara(3), Lily Arsanti Lestari(4)

(1) Prodi Ilmu Gizi, Fakultas Ilmu Kesehatan Universitas Respati Yogyakarta
(2) Prodi Gizi Kesehatan, Fakultas Kedokteran Universitas Gadjah Mada
(3) Bagian Penyakit Dalam, Rumah Sakit Umum Pusat Dr Sardjito
(4) Prodi Gizi Kesehatan, Fakultas Kedokteran Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Background: Prevalence of Indonesian elderly has now reached 7%, which is considerably high. Physical performance is an important health status indicator in elderly. Declining of physical performance such as hand grip strength in elderly is related to oxidative stress. Furthermore, oxidative stress plays an important role on the decreasing of skeletal muscle function. Plasma malondialdehyde (MDA) is a lipid peroxidation residue that is often used as an oxidative stress biomarker. Meanwhile, tea is the most widely drunk beverage after water. Green tea contains antioxidants that can reduce the damages caused by oxidative stress.

Objective: To assess the effect of green tea extract (GTE) on plasma malondialdehyde level and hand grip strength of elderly.

Method: This was a double-blind experimental with pre-post test and control group. Fifty-seven elderly people from Balai Pelayanan Social Tresna Wredha (BPSTW) Abiyoso and Budi Luhur who met inclusion and exclusion criteria were divided into 2 groups. During 30 days, the first group was given 2 capsules of GTE a day (±168 mg catechin and 95 mg Epigallocatechin gallate (EGCG) and the second group was given a placebo. MDA was measured by thiobarbituric acid  (TBA)method and hand grip strength was measured by handgrip hand grip dynamometer.

Results: There was a significant decreasing MDA (p<0,05) in the GTE group, but not in the placebo group. There was also increasing handgrip strength in the GTE group but not in the placebo group.

Conclusion: Green tea extract can prevent increasing MDA and declining physical handgrip strength in elderly.


Keywords


elderly; green tea; hand grip strength; malondialdehyde; physical performance

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References

  1. BPS. Statistik Penduduk Lanjut Usia 2014. Jakarta: BPS; 2015.
  2. Fried LP. Epidemiology of aging. Epidemiol Rev 2000;22:95–106.
  3. Bartali B, Salvini S, Turrini A. Age and disability affect dietary intake. J Nutr 2003;133(9):2868-73.
  4. Hurley BF. Age, gender, and muscular strength. J Gerontol A Biol Sci Med Sci 1995;50:41-4.
  5. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in older people. Age Ageing 2010;39(4):412-23.
  6. De La Fuente M. Effects of antioxidants on immune system ageing. Eur J Clin Nutr 2002;56:S5-8.
  7. Pansarasa O, Castagna L, Colombi B, Vecchiet J, Felzani G, Marzatico F. Age and sex differences in human skeletal muscle: role of reactive oxygen species. Free Radic Res 2000;33(3):287-93.
  8. Nielsen F, Mikkelsen BB, Nielsen JB, Andersen HR, Grandjean P. Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life style factors. Clin Chem 1997;43(7):1209-14.
  9. Tea Association of the USA. Tea fact sheet – 2014. [series online] 2014 [cited 2015 Nov 23]. Available from: URL: http://www.teausa.com/14655/tea-fact-sheet
  10. Erba D, Riso P, Colombo A, Testolin G. Supplementation of Jurkat T cells with green tea extract decreases oxidative damage due to iron treatment. J Nutr 1999;129(12):2130-4.
  11. Freese R, Basu S, Hietanen E, Nair J, Nakachi K, Bartsch H, Mutanen M. Green tea extract decreases plasma malondialdehyde concentration but does not affect otehr indicators of oxidative stress, nitric oxide production, or hemostatic factors during a highlinoleic acid diet in healthy females. Eur J Nutr 1999;38(3):149-57.
  12. Coimbra S, Castro E, Rocha-Pereira P, Rebelo I, Rocha S, Santos Silva A. The effect of green tea in oxidative stress. Clin Nutr 2006;25(5):790-6.
  13. Tinahones FJ, Rubio MA, Garrido-Sa´nchez L, Ruiz C, Gordillo E, Cabrerizo L, Cardona F. Green tea reduces LDL oxidability and improves vascular function. J Am Coll Nutr 2008;27(2):209-13.
  14. Gunawijaya, FA. Penentuan LD-50 ekstrak teh hijau pada mencit strain C3H. Maj Ilm Kedokteran USAKTI 1999;15(4):1645-50.
  15. Cesari M, Pahor M, Bartali B, Cherubini A, Penninx BW, Ferrucci L, et al. Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. Am J Clin Nutr 2004;79(2):289-94.
  16. Lemeshow S, Hosmer Jr DW, Stephen KL. Besar sampel dalam penelitian kesehatan. Yogyakarta: Gadjah Mada University Press; 1997.
  17. Rosner B. Fundamentals of biostatistics, seventh edition. Boston: Brooks/Cole Cengage Learning; 2010.
  18. Hollman PCH, Feskens EJM, Katan MB. Tea flavonols in cardiovascular disease and cancer epidemiology. Proc Soc Exp Biol Med 1999;220(4):198-202.
  19. Frei B, Higdon JV. Antioxidant activity of tea polyphenols in vivo: evidence from animal studies. J Nutr 2003;133(10):3275S-84S.
  20. Skrzydlewska E, Ostrowska J, Farbiszewski R, Michalak K. Protective effect of green tea against lipid peroxidation in the rat liver, blood serum and the brain. Phytomedicine 2002;9(3):232-8.
  21. Yokozawa T, Nakagawa T, Kitani K. Antioxidative activity of green tea polyphenol in cholesterol-fed rats. J Agric Food Chem 2002;50(12):3549-52.
  22. Negishi H, Xu JW, Ikeda K, Njelekela M, Nara Y, Yamori Y. Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. J Nutr 2004;134(1):38-42
  23. Block G, Dietrich M, Norkus EP, Morrow JD, Hudes M, Caan B, Packer L. Factors Associated with Oxidative Stress in Human Populations. Am J Epidemiol. 2002;156(3):274-85.
  24. Nazarina, Christijani R, Sari YD. Faktor-faktor yang berhubungan dengan kadar malondialdehyde plasma pada penyandang diabetes mellitus tipe 2. Jurnal Gizi Klinik Indonesia 2013;9(3):139-46.
  25. Edington J, Barnes R, Bryan F, Dupree E, Frost G, Hickson M. A prospective randomised controlled trial of nutritional supplementation in malnourished elderly in the community: clinical and health economic outcomes. Clin Nutr 2004;23(2):195-204.
  26. Cesari M, Fielding RA, Pahor M, Goodpaster B, Hellerstein M, Abellan van Kan G. Biomarkers of sarcopenia in clinical trials. Recommendations from the International Working Group on sarcopenia. J Cachexia Sarcopenia Muscle 2012;3(3):181-90.
  27. Holst B, Williamson G. Nutrients and phytochemicals: from bioavailability to bio efficacy beyond antioxidants. Curr Opin Biotechnol 2008;19(2):73-82.
  28. Gertz MA, Comenzo R, Falk RH, Fermand JP, Hazenberg BP, Sanchorawala V, et al. Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis. Am J Hematol 2004;79(4):319-28.
  29. Greenblat DJ. Reduced serum albumin concentration in the elderly: a report from the Boston Collaborative Drug Surveillance Program. J Am Geriatr Soc 1979;27(1):20-2.
  30. Ishii T, Ichikawa T, Minoda K, Kusaka K, Ito S, Nakayama T, et al. Human serum albumin as an antioxidant in the oxidation of (-)-epigallocatechin gallate: participation of reversible covalent binding for interaction and stabilization. Biosci Biotechnol Biochem 2011;75(1):100-6.



DOI: https://doi.org/10.22146/ijcn.22833

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