Efek asam alfa lipoat terhadap insulitis pada tikus diabetes melitus tipe 2

https://doi.org/10.22146/ijcn.31701

Ismawati Ismawati(1*), Mukhyarjon Mukhyarjon(2), Ilhami Romus(3), Sonia Dinda Paramitha(4)

(1) Kelompok Jabatan Fungsional Dosen Biokimia, Fakultas Kedokteran Universitas Riau
(2) Kelompok Jabatan Fungsional Dosen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Riau
(3) Kelompok Jabatan Fungsional Dosen Patologi Anatomi, Fakultas Kedokteran Universitas Riau
(4) Program Studi Kedokteran, Fakultas Kedokteran Universitas Riau
(*) Corresponding Author

Abstract


Effect of alpha lipoic acid on insulitis in type 2 diabetic rat

Background: The damaging of β cell causes hyperglycemia. Β cell damaged as insulitis happens because of the increase of free radical and the decrease of endogen antioxidant that caused oxidative stress.

Objective: The goal of this research was to find out the effect of alpha lipoic acid (ALA) on pancreas Langerhans island’s histopathology in type 2 diabetic rats.

Methods: This was an experimental laboratory study with post test only design. Fifteen adult male rats of  Wistar strain were segregated into three groups (n=5) labeled as control, type 2 diabetes (DM), and DM+ALA. The experiment was designed for 3 weeks. The measured parameter was insulitis level on pancreas Langerhans island of groups labeled.

Results: The statistical test result showed there was the significant difference between control and type 2 diabetes group (p=0,005), but there was no significant difference between DM and DM+ ALA group (p=0,549).

Conclusions: Although not statistically significant, giving ALA 60 mg/kg body weight for 3 weeks decreased the degree of insulitis in diabetic rats.

Keywords


alpha lipoic acid; diabetes mellitus; insulitis

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DOI: https://doi.org/10.22146/ijcn.31701

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