Pemberian minuman secang (Caesalpinia sappan l.) terhadap kadar malondialdehid plasma dan kebugaran jasmani pada pegawai penderita prehipertensi

https://doi.org/10.22146/ijcn.33242

Farida Fitriyanti(1*), Susetyowati Susetyowati(2), Mae Sri Hartati Wahyuningsih(3)

(1) Minat Gizi dan Kesehatan, Program Studi Magister Ilmu Kesehatan Masyarakat, Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan Universitas Gadjah Mada
(2) Departemen Gizi dan Kesehatan, Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan Universitas Gadjah Mada
(3) Departemen Farmakologi, Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan Universitas Gadjah Mada / Pusat Kedokteran Herbal, Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Effect of Secang (Caesalpinia sappan L.) drink toward plasma-malondialdehyde level and physical fitness in prehypertensive government office worker

Background: Prehypertension is associated with a higher risk of hypertension and cardiovascular disease. A government office worker has lower physical activity, thus increasing the risk of hypertension, low physical fitness, and a higher level of oxidative stress. Free radical which is the product of oxidative stress can be reduced by antioxidants. Secang (Caesalpinia sappan L.) is one of the ingredients in a traditional herbal drink (jamu) and a natural source of antioxidants in the form of polyphenol.

Objective: The purpose of this study is to discover the effect of secang drink supplementation, and efficacy towards plasma MDA level and physical fitness on a government office worker.

Methods: This study conducted with true experimental by pre and post-test control group design. The subject is 35 prehypertensive government office workers aged between 25-45 years old in Yogyakarta, divided into treatment and control groups. Secang is given in 3.8g teabag which brewed in 200cc hot water, consumed for 4 weeks. Plasma MDA level is measured using TBARS, and physical fitness is measured using the Harvard step test. Results are analyzed using student paired t-test, Pearson and Spearman correlation test, regression test, and ANOVA.

Results: There’s insignificant decrease of plasma MDA level between intervention group (from 4,28±3,16 to 3,66±1,21) and control group (4,85±2,35 to 3,65±1,33). There’s difference on Harvard step test results, intervention group increase from 35,54±20,18 to 48,09±21,86 in male, while 11,56±4,94 to 13,87±6,25 in female. In control group, male subject increase 29,20±10,06 to 38,18±23,62, but decrease 13,30±7,12 to 13,26±2,92 in female.

Conclusions: 4 weeks drinks of 3.8 g Secang drink brewed in 200ml hot water, shows no evidence of lowering oxidative stress (MDA) in plasma, but it may increase physical fitness.


Keywords


Caesalpinia sappan L.; MDA; physical fitness; prehypertension

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References

  1. Balitbangkes. Riset kesehatan dasar (Riskesdas) tahun 2013. Jakarta: Kementerian Kesehatan Republik Indonesia [series online] 2013 [cited 2016 Oktober 11]. Available from: URL: https://www.depkes.go.id/resources/download/general/Hasil%20Riskesdas%202013.pdf
  2. Balitbangkes. Riset kesehatan dasar (Riskesdas) tahun 2018. Jakarta: Kementerian Kesehatan Republik Indonesia [series online] 2018 [cited 2019 Januari 23]. Available from: URL: https: http://labmandat.litbang.depkes.go.id/images/download/laporan/RKD/2018/Laporan_Nasional_RKD2018_FINAL.pdf
  3. Collier SR, Landram MJ. Treatment of prehypertension: lifestyle and/or medication. Vasc Health Risk Manag. 2012;8:613-9. doi: 10.2147/VHRM.S29138
  4. Dinas Kesehatan Kota Yogyakarta. Inisiasi pos pembinaan terpadu. Yogyakarta: Balaikota Kota Yogyakarta; 2015.
  5. Rodrigo R, Passalacqua W, Araya J, Orellana M, Rivera G. Implications of oxidative stress and homocysteine in the pathophysiology of essential hypertension. J Cardiovasc Pharmacol. 2003;42(4):453-61. doi: 10.1097/00005344-200310000-00001
  6. Suhartono E, Fachir H, Setiawan B. Kapita selekta biokimia: stres oksidatif dasar & penyakit. Banjarmasin: Pustaka Buana; 2007.
  7. Raymond JL, Sarah CC. Medical nutrition therapy for cardiovascular disease. In: Mahan L.K. Krause’s Food and the Nutrition Care Process. 13rd ed. USA: Elsevier; 2012.
  8. Diana D, Bastman B, Jull K. Low physical actitivity work-related and other risk factor increased the risk of poor physical fitness in cemen workers. Med J Indones. 2009;18:203-7. doi: 10.13181/mji.v18i3.362
  9. Rodrigo R, Gonzales J, Valls N, Roberto B. Essential hypertension and oxidative stress: New insights. World J Cardiol. 2014;6(6):353-66. doi: 10.4330/wjc.v6.i6.353
  10. Kumawat M, Sharma TK, Singh I, Kharb S. Oxidative stress in patiens with hypertension. Journal of Advance Researches in Biological Sciences 2013;5(4):352-356.
  11. Wichitsranoi J, Weerapreeyakul N, Boonsiri P, Settasatian C, Settasatian N, Komanasin N, et al. Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans. Nutr J. 2011;10:82. doi: 10.1186/1475-2891-10-82
  12. Makaryani I, Amalia L, Ramadhani NR, Pertiwi KI, Aprilia DD. Pengaruh pemberian pangan antioksidan terhadap kadar malondialdehid plasma mahasiswi penyuka gorengan. Jurnal Gizi Klinik Indonesia 2014;10(4):169-79. doi: 10.22146/ijcn.18868
  13. Badami S, Moorkoth S, Rai SR, Kannan E, Bhojraj S. Antioxidant activity of caesalpinia sappan heartwood. Biol Pharm Bull 2003;26(11):1534-7. doi: 10.1248/bpb.26.1534
  14. Santosa AP. Konsumsi minuman isotonik antosianin kulit kedelai hitam (Glycine max (L) Merrit) dalam hubungannya dengan kebugaran dan aktivitas antioksidan pada orang yang diuji fisik dengan meode HST (Harvard Step Up Test): studi komparatif pada perokok dan non perokok [Thesis]. Yogyakarta: Pascasarjana Universitas Gadjah Mada; 2015.
  15. Rosidi A. Pengaruh pemberian ekstrak temulawak (Curcuma xanthorrhiza Roxb) terhadap stres oksidatif dan kesegaran jasmani atlet [Thesis]. Bogor: Institut Pertanian Bogor; 2014.
  16. Nirmal NP, Rajput MS, Prasad RGSV, Ahmad M. Brazilin from Caesalpinia sappan hearthwood and its pharmacological activities: a review. Asian Pac J Trop Med. 2015;8(6):421-30. doi: 10.1016/j.apjtm.2015.05.014
  17. Pusat studi pangan dan gizi (PSPG). Laporan hasil uji secang celup. Yogyakarta: Universitas Gadjah Mada; 2016.
  18. Madhusudhan U. The relationship between waist to stature ratio & physical fitness index in adult males. International Journal of Medical and Health Research. 2016;2(7):38-40.
  19. Nadimin. Pola makan, aktivitas fisik dan status gizi pegawai Dinas Kesehatan Sulawesi Selatan. Media Gizi Pangan. 2011;XI(1):1-6.
  20. Balitbangkes. Riset kesehatan dasar (Riskesdas) tahun 2007. Jakarta: Kementrian Kesehatan Republik Indonesia [series online] 2007 [cited 2016 Oktober 11]. Available from: URL: http://kesga.kemkes.go.id/images/pedoman/Riskesdas%202007%20Nasional.pdf
  21. Prasetyo Y, Widiyanto. Latihan tidak teratur dan kerusakan jaringan. Medikora. 2006;2(2):191-203.
  22. Dewi ACN, Mahmudiono T. Hubungan pola makan, aktivitas fisik, sikap, dan pengetahuan tentang obesitas dengan status gizi pegawai negeri sipil di kantor Dinas Kesehatan Provinsi Jawa Timur. Media Gizi Indonesia. 2013;9(1):42-8.
  23. Gibson RS. Validity in dietary assessment methods: Principles of nutritional assessment, second edition. England: Oxford University Press; 2005.
  24. Widyakarya Nasional Pangan dan Gizi. Angka kecukupan gizi (AKG) Indonesia tahun 2013. Jakarta: Departemen Kesehatan Republik Indonesia; 2013.
  25. Widowati W. Uji fitokimia dan potensi antioksidan ektrak etanol kayu secang (Caesalpinia sappan L.). JKM. 2011;11(1):23-31.
  26. Duthie SJ, Alison McE J, Alan C, William M, Lynn P, Janet K, et al. The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in health human volunteers. Eur J Nutr 2006;45(2):113-22. doi: 10.1007/s00394-005-0572-9
  27. Riso P, Francesco V, Claudio G, Simona G, Antonella B, Fabio G, et al. Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stress. J Agric Food Chem. 2005;53(4):941-7. doi:10.1021/jf0485234
  28. Heaney RP. Factors influencing the measurement of bioavailability, taking calcium as a model. J Nutr 2001;131(4):1344S-8S. doi: 10.1093/jn/131.4.1344S
  29. McDougall G, Patricia D, Pauline S, Alison B, Derek S. Assessing potential bioavailability of raspberry anthocyanins using an in vitro digestion system. J Agric Food Chem. 2005;53(15):5896-904. doi: 10.1021/jf050131p
  30. Denev PN, Kratchanov CG, Ciz M, Lojek A, Kratchanova MG. Bioavailability and antioxidant activity of black chokeberry (Aronia melanocarpa) polyphenols: in vitro and in vivo evidences and possible mechanisms of action: a review. Compr Rev Food Sci Food Saf 2012:11(5):471-89. doi: 10.1111/j.1541-4337.2012.00198.x
  31. Darawati M, Riyadi H, Damayanthi E, Kustiyah L. Effects of functional breakfast product on oxidative stress in overweight/obese students. International Journal of Sciences: Basic and Applied Research (IJSBAR) 2015;24(7):278-88.
  32. Vincent HK, Innes KE, Vincent KR. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes Metab. 2007;9(6):813-39. doi: 10.1111/j.1463-1326.2007.00692.x
  33. Sandoval AC, Ferreira J, Speisky H. Polyphenols and mitochondria: an update on their increasingly emerging ROS-scavenging independent actions. Arch Biochem Biophys. 2014 Oct 1;559:75-90. doi: 10.1016/j.abb.2014.05.017
  34. Huxley VH. Sex and cardiovascular system: the intriguing tale of how women and men regulate cardiovascular function differently. Adv Physiol Educ. 2007;31(1):17-22. doi: 10.1152/advan.00099.2006
  35. Sandbakk O, Gertjan E, Stig L, Hans CH. Gender differences in the physiological responses and kinematic behavior of elite sprint cross-country skiers. Eur J App Physiol. 2012;112(3):1087-94. doi: 10.1007/s00421-011-2063-4
  36. Armstrong LE. Assessing hydration status: the elusive gold standard. J Am Coll Nutr 2007;26(5 Suppl):575S-584S. doi: 10.1080/07315724.2007.10719661
  37. Teixeira PJ, Eliana VC, David M, Marlene NS, Ricard MR. Exercise, physical activity, and self-determination theory: a systematic review. Int J Behav Nutr Phys Act. 2012;9:78. doi: 10.1186/1479-5868-9-78
  38. Kline GM, Porcari JP, Hintermeister R, Freedson PS, Ward A, McCarron RF, et al. Estimation of VO2max from a one-mile track walk, gender, age, and body weight. Med Sci Sports Exerc. 1987;19(3):253-9.



DOI: https://doi.org/10.22146/ijcn.33242

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