Ekspresi Syndecan-1, Matriks Metalloproteinase-2 dan IL-1α pada Ameloblastoma Multikistik (Penelitian Restrospektif Analitik di RSUP Dr. Sardjito Tahun 2010-2014)

Abstract

Back ground : Characteristic of multycystic ameloblastoma is high recurency and high incidens. The aim of this study was to provide explanation of invasive ability, metastatic ability, growth progresivity, bone ostelysis, and recurrence of multicystic
ameloblastoma in molecular level. Metodology : Paraffin block from Anatomical Pathology Installation of RSUP Dr. Sardjito 2010 – 2014, consisting of 14 follicular, 13 plexiform, 7 acantomathous, 2 granular, and 1 desmoplastic stained in HE and IHC Syndecan-1, MMP-2, and IL-1α were included in this study. The presence, localization, distribution pattern, and colour intensity of immunoreactive cells were observed using light microscope. The expression of Syndecan-1, MMP-2, and IL-1α were analyzed using Kruskall Wallis test, comparison using Mann-Whitney test, and correlation using Spearman rho test with significance P<0,05. Result : shows there
are significant difference in immunoscoring expression of Syndecan-1 in epithel (P=0,031), MMP-2 (P=0,04), and IL-1α (P=0,049) in many types of Multicystic ameloblastoma. The results show corellation between MMP-2 and Syndecan-1 stroma expression (P=0,002) in acanthomatous type, IL-1α and Syndecan-1 epithel expression (P=0,00) in foliculair and acanthomatous type, also IL-1α and Syndecan-1stroma (P=0,00) in foliculair and plexiform type. Its show that Syndecan-1, MMP-2, and IL-1α synergicaly interracted to form an invasive and aggresive ameloblastoma. Conclution : Foliculair type, followed by acanthomatous type, shows more progressive in growth, invasive ability, metastatic ability, and recurrence compared with plexiform type.