Hubungan Pemakaian Antibiotik dengan Kejadian Infeksi Sectio Caesarea pada Pasien di RSUD Abepura Jayapura Papua

Nani Emma(1*), Ova Emilia(2), Shinta Prawitasari(3)

(1) RS Abepura, Jayapura, Papua
(2) Bagian Obstetri Ginekologi, Fakultas Kedokteran, UGM
(3) Bagian Obstetri Ginekologi, Fakultas Kedokteran, UGM
(*) Corresponding Author


Background: The number of caesarean section (CS) operations in the world has increased sharply within the last 20 years. Increase of the need for CS operations also increases the problem related to surgical process. Infection happens about 2% to 16% after CS operation. The incidence of post CS is associated with some factors such as supplementation of prophylaxis antibiotics, duration of childbirth, width of membrane wound, duration of surgical nursing monitoring and number of CS. CS infection associated with antibiotic use occurs before or after CS operation. The incidence increases 3 times in patients that do not use antibiotics before CS operation. Use of prophylaxis antibiotics in CS operation significantly minimizes the incidence of infection.

Objective: To identify antibiotic use according to standard operational procedure to the incidence of infection in CS mothers.

Method: The study was analytical with cross sectional design, undertaken at Abepura Local Hospital. Population were all mothers who gave birth through CS at the hospital. Samples were taken using systematic random sampling technique as many as 44 samples. Data were obtained through questionnaire, interview and document studies  and analyzed using chi square and logistic regression test, risk prevalence at confidence interval (CI) 95% and significance p<0.05.

Result: The majority of subject (56.82%) had no infection; 59.09% used antibiotics according to the procedure; 52.27% had good nutrition status; 54.55% had emergency operation; 50% had anemia. Average length of CS operation was 2.26 +1.38 hours. There was significant association between antibiotic use, nutrition status, Hb level, and types of operation and the incidence of CS infection (p<0.05). The result of multivariate analysis showed there was significant association between antibiotic use, nutrition status, types of operation and the incidence of infection. Use of antibiotic brought dominant risk for the incidence of CS infection (PR=2.36; 95% CI=1.45-3.38) whereby antibiotic use, nutrition status and types of operation could predict the incidence of CS infection as much as 10.7%.

Conclusion: The majority of subject had no infection and used antibiotic according to the procedure. The probability for the incidence of CS infection was greater in antibiotic use irrelevant with the procedure. Factor most dominantly affecting the incidence of CS infection was antibiotic use irrelevant with the procedure.


Keywords: antibiotic use, caesarean section, incidence of infection


antibiotic use; caesarean section; incidence of infection;

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Roeshadi R.H. Sulbaktam/ampisilin sebagai antibiotika profilaksis pada seksio sesaria elektif di RSIA Rosiva Medan, Cermin Dunia Kedokteran, 2006; 151. Kaplan, N.M., Smadi, A.A., Al-Taani, M.I. & El-Qudah, M.A. Microbiology of wound infection after caesarean section in a Jordanian hospital. East Mediterr Health, 2003;9(5-6):1068-1074 Mah, M.W., Pyper, A.M., Oni,G.A. & Memish, Z.A.Impact of antibiotic prophylaxis on wound infection after cesarean section in a situation of expected higher risk, Am J Infect Control, 2001;29(2): 85-88 Dumas A.M.,, Girard R.L., Ayzac L, Vallet E.C., Guerraz, F.O.T., Bouletreau, A.V. & Berland, M. Maternal infection rates after cesarean delivery by Pfannenstiel or Joel–Cohen incision: a multicenter surveillance study, European Journal of Obstetrics & Gynecology and Reproductive Biology, 2009;147:139–143 Balkhy, H.H., Memish, Z.A. & Almuneef, M.A. Effect of intensive surveillance on cesarean section wound infection rate in a Saudi Arabian hospital, Am J Infect Control, 2003;31:288-90. Smaill, F & Hofmeyr, G.J. Antibiotic prophylaxis for cesarean Section (review), The Cochrane database Syst Rev, 2007;(3): CD0030933. Vermillion, S.T., Carlos M.D., Vermillion, S.T., Lamoutte, M.D.C., David, M.D . Soper, M.D. & Verdeja, M.D. Wound Infection After Cesarean: Effect of Subcutaneous Tissue Thickness; 2000. RSUD Abepura. Profil rumah sakit Abepura; Pencatatan dan pelaporan rekam medik; 2009. Nichols, R.L. Preventing surgical site infections: a surgeon’s perspective, emerging Infectious Diseases, 2001; 7(2). Ratanakorn, W., Srijariya, W., Chamnanvanakij, S. & Saengaroon, P. Incidence of neonatal infection in newborn infants with a maternal history of premature rupture of membranes (PROM) for 18 hours or longer by using phramongkutklao hospital clinical practice guideline (CPG). Med Association Thai, 2005;88(7): 973-978. Mugford, M., Kingston, J. & Chalmers, I. Reducing the incidence of infection after caesarean section: implications of prophylaxis with antibiotics for hospital resources, British Medical Journal, 1989; 299: 1006-8. Carlson, C. & Duff, P. Antbiotic Prophylaxis for cesarean delivery: Is an extended-spectrum agent necessary, Obstetric and gynecology, 1990;76 (3):343-346. Ezechi, O.C., Edet, A., Akinlade, H., Okafor, C.V.G. & Ebiere Herbertson, E. Incidence and risk factors for caesarean wound infection in Lagos Nigeria, BMC Research Notes, 2009;2:186. Khan, F.A., Khan, M., Ali, A. & Chohan, U., (2006) Estimation of blood loss during Caesarean Section: an audit. J Pak Med Assoc. 2006; 56(12). Johnson, A., Young, D. & Reilly, J. Caesarean section surgical site infection surveillance, J Hosp Infect, 2006; 1-6.


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