Deteksi Dini Conventional Smear dan Liquid Based Cytology dalam Upaya Pencegahan Kanker Serviks: Literature Review

https://doi.org/10.22146/jkr.42627

Ayu Indah Lestari(1*), Budi Hidayat(2)

(1) S2 Ilmu Kesehatan Masyarakat Universitas Indonesia
(2) Departemen Administrasi dan Kebijakan Kesehatan, Fakultas Kesehatan Masyarakat Universitas Indonesia
(*) Corresponding Author

Abstract


Background: Cervical cancer is the most common cancer among women. Cervical cancer mortality is also an indicator of health success, because 86% of all deaths due to cervical cancer are in developing, low and middle income countries. Cervical cancer is caused by the Human Papilloma Virus (HPV), one of the most common sexually transmitted infections in the world.

Objective: This literature review aims to describe early detection of pap smear (Conventional Smear and Liquid Based Cytology) as prevention of cervical cancer.

Method: This review used the literature review method to search all related and relevant articles in PubMed, ProQuest, Science Direct and Portal Garuda with publications between 2008-2018.

Results and Discussion: Liquid Based Cytology sensitivity (88%) is much higher than that reported in Conventional Smear (20-30%), Liquid Based Cytology examination has the potential to increase sensitivity in the diagnosis of endometrial carcinoma.

Conclusion: Although conventional smear sensitivity is lower than Liquid Based Cytology, the price of conventional smear is more affordable for the community, and the target of Liquid Based Cytology is adapted for the upper middle class. To improved conventional smear effectiveness can be accompanied by IVA examination so that it is not repeated, more practical, and higher validity.


Keywords


early detection; conventional smear; liquid based cytology; cervical cancer

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References

  1. Srivastava A, Misra J, Srivastava S, Singh U. Risk-factors and strategies for control of carcinoma cervix in India: Hospital based cytological screening experience of 35 years. Indian J Cancer. 2009;46(2):155.
  2. Menkes RI. Permenkes RI no.29 Tahun 2017 Tentang Penanggulangan Kanker Payudara dan Kanker Leher Rahim. 2017;
  3. IARC. Latest Global Cancer Data, 2018. World Heal Organ [Internet]. 2018;(September):13–5. Available from: http://www.who.int/cancer/PRGlobocanFinal.pdf
  4. Kesehatan K, Indonesia R. Pedoman Nasional Pelayanan Kedokteran Kanker Serviks. 2017;
  5. Nishio H, Iwata T, Nomura H, Morisada T, Takeshima N, Takano H, et al. Liquid-based cytology versus conventional cytology for detection of uterine cervical lesions: A prospective observational study. Jpn J Clin Oncol. 2018;48(6):522–8.
  6. Morisada T, Saika K, Saito E, Kono K, Saito H, Aoki D. Population-based cohort study assessing the efficacy of cervical cytology (Pap smear) and human papillomavirus (HPV) testing as modalities for cervical cancer screening. Jpn J Clin Oncol. 2018;48(5):495–8.
  7. Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (prisma-p) 2015: Elaboration and explanation. BMJ. 2015;1–9.
  8. Sams SB, Currens HS, Raab SS. Liquid-based papanicolaou tests in endometrial carcinoma diagnosis: Performance, error root cause analysis, and quality improvement. Am J Clin Pathol. 2012;137(2):248–54.
  9. Haghighi F, Ghanbarzadeh N, Ataee M, Sharifzadeh G, Mojarrad J, Najafi-Semnani F. A comparison of liquid-based cytology with conventional Papanicolaou smears in cervical dysplasia diagnosis. Adv Biomed Res [Internet]. 2016;5(1):162. Available from: http://www.advbiores.net/text.asp?2016/5/1/162/192735
  10. Jeong H, Hong SR, Chae S-W, Jin S-Y, Yoon HK, Lee J, et al. Comparison of Unsatisfactory Samples from Conventional Smear versus Liquid-Based Cytology in Uterine Cervical Cancer Screening Test. J Pathol Transl Med [Internet]. 2017;51(3):314–9. Available from: http://jpatholtm.org/journal/view.php?doi=10.4132/jptm.2017.03.17
  11. Sangeeta Pankaj, Syed Nazneen, Simi Kumari, Anjili Kumari, Anita Kumari JK, Vijayanand Choudhary1 SK. Comparison of conventional Pap smear and liquid‑based cytology: A study of cervical cancer screening at a tertiary care center in Bihar. Indian J Cancer [Internet]. 2018;54(Supplement1):S45–54. Available from: http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2016;volume=53;issue=4;spage=562;epage=565;aulast=Madhavan
  12. Unim B, Meggiolaro A, Semyonov L, Maffongelli E, Torre G La. Role of pap-test in cervical cancer prevention: a systematic review and meta-analysis. 2014;24:286–7.
  13. Widjajahakim G, Amerika D. Peran Liquid-Based Cytology ( LBC ) dalam Skrining Kanker Serviks. Cermin Dunia Kedokt. 2012;39(2):139–40.
  14. WHO. Comprehensive Cervical Cancer Control. WHO Libr Cat Data [Internet]. 2014;364. Available from: http://www.who.int/reproductivehealth/publications/cancers/cervical-cancer-guide/en/
  15. Grigore M, Popovici R, Pristavu A, Grigore AM, Matei M, Gafitanu D. Perception and use of Pap smear screening among rural and urban women in Romania. Eur J Public Health. 2017;27(6):1084–8.
  16. Menkes RI. Permenkes RI No.43 Tahun 2016 Tentang Standar Pelayanan Minimal Bidang Kesehatan. 2016;79. Available from: http://djsn.go.id/storage/app/uploads/public/58d/486/f01/58d486f010a3f067108647.pdf
  17. Diaz M, Moriña D, Rodríguez-Salés V, Ibáñez R, Espinás JA, de Sanjosé S. Moving towards an organized cervical cancer screening: costs and impact. Eur J Public Health. 2018;28(6):1132–8.
  18. Ron C. Bowditch, B.Sc.Ag, C.T. A.S.C. CMIAC, Joanne M. Clarke, C.T. A.S.C., N.Z.C.T.S. (Paramedical) CTC (WA), Phillip J. Baird, M.B.B.S., F.R.C.P.A., F.I.A.C., F.A.C.L.M. A, Merle L. Greenberg, M.B.B.Ch., F.R.C.P.A. FIAC. Results of an Australian Trial Using SurePath Liquid-Based Cervical Cytology with FocalPoint Computer-Assisted Screening Technology. 2011;89(6):854–63.
  19. Arbyn M, Anttila A, Jordan J, Ronco G, Schenck U, Segnan N, et al. European guidelines for quality assurance in cervical cancer screening. Second edition-summary document. Ann Oncol. 2010;21(3):448–58.
  20. BPJS Kesehatan. Info BPJS Kesehatan: Media Eksternal BPJS Kesehatan. Ed 35 [Internet]. 2016; Available from: https://www.bpjs-kesehatan.go.id/bpjs/dmdocuments/461cfbfccf76887f956d6aafe5ca0a7f.pdf
  21. BPS. Perempuan dan Laki-laki di Indonesia 2016. Badan Pus Stat. 2016;60.



DOI: https://doi.org/10.22146/jkr.42627

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