Pengaruh Pemberian Buah Kurma Ajwa (Phoenix dactilyfera L) terhadap Kadar Hormon Anti-Mullerian (AMH) dan Gambaran Klinis Perempuan Perimenopause

https://doi.org/10.22146/jkr.72298

Farah Ekawati Mulyadi(1), Rosdiana Natsir(2), Nasrudin Andi Mappaware(3*), Suryani As'ad(4), Andi Wardihan Sinrang(5), Liong Boy Kurniawan(6)

(1) Magister Ilmu Biomedik, Sekolah Pascasarjana, Universitas Hasanuddin/ Departemen Fisiologi, Faklutas Kedokteran, Universitas Muslim Indonesia
(2) Departemen Biokimia, Fakultas Kedokteran, Universitas Hasanuddin
(3) Departemen Obstetri dan Ginekologi, Fakultas Kedokteran, Universitas Muslim Indonesia
(4) Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Hasanuddin
(5) Departemen Fisiologi, Fakultas Kedokteran, Universitas Hasanuddin
(6) Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Hasanuddin
(*) Corresponding Author

Abstract


Background: Perimenopause is clinically characterized by the appearance of various complaints such as disturbed menstrual cycles, vasomotor symptoms, and mood changes that have an impact on reduced quality of life. The decline in ovarian reserve is thought to be the beginning of this transition which eventually triggers hormonal changes. AMH is used as a marker of ovarian reserve and clinically as a predictive biomarker of menopause. Ajwa dates contain various phytochemicals that have potential to be used to protect primordial follicles from various damage while reducing perimenopause complaints.

Objective: This study aimed to analyze the effect of consumption of ajwa dates on AMH levels and clinical features of perimenopausal women.

Methods: This quasi-experimental study with a pre-post control design was carried out at RSIA Sitti Khadijah I Muhammadiyah Makassar, South Sulawesi, Indonesia, from May to October 2021. This study involved 44 perimenopausal subjects aged 42-48 years who were divided into 2 groups randomly (28 intervention groups, 16 control groups). AMH levels were checked by ELISA method while the clinical features was assessed by clinical examination.

Results and Discussion: AMH levels in the intervention group decreased more slowly than the control group (0.37 ± 0.36 ng/ml vs 0.55 ± 0.19 ng/ml, p<0.05). Complaints of sleep disturbances, vaginal dryness, and mood changes were better in the intervention group (p<0.05), while complaints of irregular menstrual cycles and hot flushes were not significantly different in either control and intervention groups.

Conclusion: AMH levels in the intervention group decreased more slowly than in the control group. The clinical features in the intervention group were better than the control group. Ajwa dates can be a good nutrition in improving the quality of life of perimenopausal women.

Keywords: Anti-Mullerian Hormone (AMH); Clinical Features; Ajwa Dates; Perimenopause.


Keywords


reproductive health; aging; perimenopause; woman's health

Full Text:

PDF


References

  1. Cheung AM, Chaudhry R, Kapral M, Jackevicius C, Robinson G. Perimenopausal and Postmenopausal Health. BMC Womens Health. 2004;4(Suppl 1):S23. doi:10.1186/1472-6874-4-s1-s23
  2. Prior JC. [Frontiers in Bioscience S3, 474-486, January 1, 2011] The endocrinology of perimenopause: need for a paradigm shift Jerilynn C Prior, Christine L Hitchcock. Front Biosci. Published online 2011:474-486.
  3. Delamater L, Santoro N. Management of the Perimenopause. Clin Obs Gynecol. 2018;61(3):419-432. doi:10.1097/GRF.0000000000000389.Management
  4. Shen W, Stearns V. Treatment strategies for hot flushes. Published online 2009:1133-1144.
  5. Deecher DC, Dorries K. Review Understanding the pathophysiology of vasomotor symptoms ( hot flushes and night sweats ) that occur in perimenopause , menopause , and postmenopause life stages. Art Womans Ment Heal. 2007;10(December):247-257. doi:10.1007/s00737-007-0209-5
  6. Elizarraraz NLA, E F-R, JA H-M, JM M-H. Neuropéptide Y, anti-mullerian and reproductive hormones and their relationship with vasomotor symptoms in menopausal transition. Obstet Gynecol Int J. 2018;9(4):288-294. doi:10.15406/ogij.2018.09.00349
  7. Koebele S V, Bimonte-nelson HA. Maturitas Modeling menopause : The utility of rodents in translational behavioral endocrinology research ଝ. Maturitas. 2016;87:5-17. doi:10.1016/j.maturitas.2016.01.015
  8. Yang L, Chen Y, Liu Y, Xing Y, Miao C, Zhao Y. The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging. Front Pharmacol. 2021;11(January):1-19. doi:10.3389/fphar.2020.617843
  9. Depmann M, Eijkemans MJC, Broer SL, et al. Does AMH Relate to Timing of Menopause? Results of an Individual Patient Data Meta-Analysis. J Clin Endocrinol Metab. 2018;103(October):3593-3600. doi:10.1210/jc.2018-00724
  10. De Vet A, Laven JSE, De Jong FH, Themmen APN, Fauser BCJM. Antimüllerian hormone serum levels: A putative marker for ovarian aging. Fertil Steril. 2002;77(2):357-362. doi:10.1016/S0015-0282(01)02993-4
  11. Hansen KR, Ph D, Hodnett GM, Knowlton N, Craig LB, D M. Correlation of ovarian reserve tests with histologically determined primordial follicle number. Fertil Steril. 2011;95(1):170-175. doi:10.1016/j.fertnstert.2010.04.006
  12. Sahmay S, Aydin Y, Oncul M. Diagnosis of Polycystic Ovary Syndrome : AMH in combination with clinical symptoms. J Assist Reprod Genet. 2014;2014(31):213-220. doi:10.1007/s10815-013-0149-0
  13. Kruszyńska A, Słowińska-srzednicka J. Anti-Müllerian hormone ( AMH ) as a good predictor of time of menopause. Menopause Rev. 2017;16(2):47-50.
  14. Lee Y, Chung HW, Jeong K, et al. Association between cadmium and anti- Mullerian hormone in premenopausal women at particular ages. Published online 2018:1-6.
  15. Mi Young Kim; Seung Do Aeli Ryu. Is Complementary and Alternative Therapy Effective for Women in the Climacteric Period? J Menopausal Med. 2015;21(1):28-35.
  16. Hamad I, Abdelgawad H, Jaouni S Al, et al. Metabolic Analysis of Various Date Palm Fruit (Phoenix dactylifera L.) Cultivars from Saudi Arabia to Assess Their Nutritional Quality. Molecules. 2015;20(June):13620-13641. doi:10.3390/molecules200813620
  17. Nair MG. Antioxidant and Anti-inflammatory Assays Confirm Bioactive Compounds in Ajwa Date Fruit. J Agric Food Chem. 2013;XXXX(XXX):XXX−XXX. doi:dx.doi.org/10.1021/jf401371v | J. Agric. Food Chem
  18. Rahmani AH, Aly SM, Ali H, Babiker AY, Srikar S, Amjad A. Therapeutic effects of date fruits ( Phoenix dactylifera ) in the prevention of diseases via modulation of anti-tumour activity. Int J Clin Exp Med. 2014;7(3):483-491.
  19. Royani I, As’ad S, Mappaware NA, Hatta M, Rabia. Effect of Ajwa Dates Consumption to Inhibit the Progression of Preeclampsia Threats on Mean Arterial Pressure and Roll-Over Test. Biomed Res Int. 2019;2019. doi:10.1155/2019/2917895
  20. Younas A, Naqvi SA, Khan MR, et al. Functional food and nutra-pharmaceutical perspectives of date (Phoenix dactylifera L.) fruit. J Food Biochem. 2020;44(9):1-18. doi:10.1111/jfbc.13332
  21. Saleh EA, Tawfik MS, Abu-Tarboush HM. Phenolic Contents and Antioxidant Activity of Various Date Palm (Phoenix dactylifera L.) Fruits from Saudi Arabia. Food Nutr Sci. 2011;02(10):1134-1141. doi:10.4236/fns.2011.210152
  22. Idowu AT, Igiehon OO, Adekoya AE. Dates palm fruits : A review of their nutritional components , bioactivities and functional food applications. AIMS Agric Food. 2020;5(September):734-755. doi:10.3934/agrfood.2020.4.734
  23. Freeman EW, Sammel MD, Lin H, Boorman DW, Gracia CR. Contribution of the rate of change of antimüllerian hormone in estimating time to menopause for late reproductive-age women. Fertil Steril. 2012;98(5):1254-1259.e2. doi:10.1016/j.fertnstert.2012.07.1139
  24. Moslehi N, Mirmiran P, Azizi F, Tehrani FR. Do dietary intakes influence the rate of decline in anti-Mullerian hormone among eumenorrheic women ? A population-based prospective investigation. Nutr J. 2019;18(83):1-9.
  25. Katz-Jaffe MG, Lane SL, Parks JC, Mccallie BR, Makloski R, Schoolcraft WB. Antioxidant Intervention Attenuates Aging-Related Changes in the Murine Ovary and Oocyte. Life. 2020;250(10):1-14.
  26. Dizaji F, Mojgan M, Parviz S, Alizadeh M, Oskouei S. The effect of selenium and vitamin E supplementation on anti-Mullerian hormone and antral follicle count in infertile women with occult premature ovarian insufficiency : A randomized controlled clinical trial. Complement Ther Med. 2021;56(January 2021):102533. doi:10.1016/j.ctim.2020.102533
  27. Al-Farsi MA, Lee CY. Nutritional and functional properties of dates: A review. Crit Rev Food Sci Nutr. 2008;48(10):877-887. doi:10.1080/10408390701724264
  28. Ceko MJ, Harris HH, Hummitzsch K, Rodgers RJ. Trace Elements in Ovaries : Measurement and Physiology. Biol Reprod. 2016;94(4):86,1-14. doi:10.1095/biolreprod.115.137240
  29. Xu D, Hu M, Wang Y, Cui Y. Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Molecules. 2019;24(1123):1-15. doi:10.3390/molecules24061123
  30. Wang Z, Chandrasena ER, Yuan Y, et al. Redox Cycling of Catechol Estrogens Generating Apurinic/ Apyrimidinic Sites and 8-oxo-Deoxyguanosine via Reactive Oxygen Species Differentiates Equine and Human Estrogens. 2011;23(8):1365-1373. doi:10.1021/tx1001282.Redox
  31. Agarwal A, Doshi S. The role of oxidative stress in menopause. J Midlife Health. 2013;4(3):140. doi:10.4103/0976-7800.118990
  32. Santoro N. The menopausal transition. Am J Med. 2005;118(12B):8-13. doi:10.1016/j.amjmed.2005.09.008
  33. Berendsen HHG. The role of serotonin in hot flushes. Maturitas. 2000;36:155-164.
  34. Kravitz HM, Joffe H. Sleep During the Perimenopause: A SWAN Story. Obs Gynecol Clin North Am. 2012;38(3):567-586. doi:10.1016/j.ogc.2011.06.002.Sleep
  35. Kravitz HM, Janssen I, Bromberger JT, et al. Sleep Trajectories Before and After the Final Menstrual Period in The Study of Women’s Health Across the Nation (SWAN). Curr Sleep Med Rep. 2018;3(3):235-250. doi:10.1007/s40675-017-0084-1.Sleep
  36. Santoro N, Komi J. Prevalence and Impact of Vaginal Symptoms among Postmenopausal Women. J Sex Med. 2009;6:2133-2142. doi:10.1111/j.1743-6109.2009.01335.x
  37. Avis NE, Colvin A, Karlamangla AS, et al. Change in Sexual Functioning Over the Menopause Transition: Results from the Study of Women’s Health Across the Nation (SWAN). Menopause. 2018;24(4):379-390. doi:10.1097/GME.0000000000000770.Change
  38. Kim H, Kang S, Chung Y, Kim J, Kim M. The Recent Review of the Genitourinary Syndrome of Menopause. J Menopausal Med. 2015;21:65-71.



DOI: https://doi.org/10.22146/jkr.72298

Article Metrics

Abstract views : 1528 | views : 1577

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Kesehatan Reproduksi Indexed by:

 

 



SEKRETARIAT JURNAL KESEHATAN REPRODUKSI
Departemen Obstetri dan Ginekologi, FK-KMK, UGM/RS Dr. Sardjito
Jl. Kesehatan No. 1, Sekip Utara, Yogyakarta 55281
Tlp: (0274) 511329 / Faks: (0274) 544003
Email: jurnal.kesehatanreproduksi@ugm.ac.id
Cp: Dwi Astuti +6281802698043