Local application of biphosphonate as a biochemical barrier against bone graft resorption in mandibular reconstruction

https://doi.org/10.22146/majkedgiind.45096

Romzi Hanif(1), Muhammad Masykur Rahmat(2), Cahya Yustisia Hasan(3*)

(1) RSUD Prof. Dr. Margono Soekarjo, Central Java Oral and Maxillofacial Surgery Specialty Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(2) Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(3) Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


Mandibular reconstruction to restore functions and aesthetics after mandibular resection remains a major surgical challenge. This type of reconstruction using non-vascularized autogenous bone graft harvested from iliac bone has been popular given that this bone is numerous and donor site morbidity can be minimized, however, it is highly resorbable. Local application of bisphosphonate by immersing bone graft in biphosphonate manages to inhibit bone graft resorption prior to the formation of new bone to support the osteogenesis and osteointegration of bone grafts. This paper aimed at examining the positive results of iliac bone graft osteogenesis and osteointegration following local application of bisphosphonate in mandibular reconstruction. A 22-year-old female patient came with a complaint of painless right cheek mass that has swollen slowly since 2 years. Radiographic examination showed cloudy radiolucent images in the right mandibular corpus to the right mandibular ramus, while histopathological examination indicated ossifying fibroma. Patient underwent mandibular resection followed by iliac bone graft-based mandibular reconstruction. Bone graft was immersed with bisphosphonate (zoledronate acid 0.005 mg /ml) for 3 minutes, then rinsed with saline for 3 minutes, followed by fixing bone graft on the reconstruction plate. Postoperative follow up in the 36th week showed no signs of infection and dehiscence in the surgery site, and the radiographic examination indicated signs of osteogenesis and osteointegration of mandibular bone graft. Local application of biphosponate on bone graft promotes favorable results of osteogenesis and osteointegration in mandibular reconstruction.

Keywords


biphosponate; bone graft; mandibular reconstruction; osteogenesis; osteointegration

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References

1. Hupp JR, Ellis E, Tucker MR. Contemporary oral and maxillofacial surgery 5th ed. St.Louis Missouri: Mosby Elsevier; 2008. 449-468.

 

2. Fernandes RP, Yetzer JG. Reconstruction of acquired oromandibular defect. Oral Maxillofac Surg Clin North Am. 2013; 25(2): 214-249.  doi: 10.1016/j.coms.2013.02.003

 

3. Farwell DG, Futran ND. Oromandibular reconstruction. Facial Plast Surg. 2000; 16(2): 115–126. doi: 10.1055/s-2000-12573

 

4. Wong RC, Tideman H, Kin L, Merkx MA. Biomechanics of mandibular reconstruction: a review. IJOMS. 2009; 39(4): 313-319.  doi: 10.1016/j.ijom.2009.11.003

 

5. Chim H, Salgado CJ, Mardini S, Chen HC. Reconstruction of mandibular defects. Semin Plast Surg. 2010; 24(2): 188-197. doi: 10.1055/s-0030-1255336

 

6. Mounir M, Abou-ElFetouh A, El-Beialy W, Faramawey M, Mounir R. Vascularized versus non-vascularized autogenous bone graft for immediate reconstruction of segmental mandibular defects: a systematic review. OHDM. 2015; 14(6): 337-349.

 

7. Kesteris U and Aspenberg P. Rinsing morcellised bone grafts with biphosphonate solution prevents their resorption: a prospective randomized double-blinded study. J Bone Joint Surg Br. 2006; 88(8): 993-996. doi: 10.1302/0301-620X.88B8.17457

 

8. Alfotawi R, Ayoub A. Reconstruction of maxillofacial bone defects: contemporary methods and future techniques. Am J Adv In Med Sc. 2014; 2(1): 18-27.

 

9. Buchbinder D, Arken M. Mandibular reconstruction. Head & Neck Surg-Otolaryngol. 1993; 2: 1980-1999.

 

10. Martín-Granizo R, Sánchez-Cuellar A, Falahat F. Cemento ossifying fibroma of the upper gingivae. Otolaryngol Head Neck Surg. 2000; 122(5): 775. doi: 10.1016/S0194-5998(00)70216-6

 

11. Triantafilidou K, Karakinaris G, Psomaderis K, Iordanisdis F, Karakasis D. Fibrous dysplasia of craniomaxillofacial bones a clinical study of 18 cases and review of the literature. BJDM. 2014; 18(2): 99-105. doi: 0.1515/bjdm-2015-0016

 

12. Gondivkar SM, Gadbail AR, Chole R, Parikh RV, Balsaraf S. Ossifying fibroma of the jaws: report of two cases and literature review. Oral Oncol. 2011; 47(9): 804-809. doi: 10.1016/j.oraloncology.2011.06.014

 

13. Toyosawa S, Yuki M, Kishino M, Ogawa Y, Ueda T, Murakami S, Konishi E, Lida S, Kogo M, Komori T, Tomita Y. Ossifying fibroma vs fibrous dysplasia of the jaw: molecular and immunological characterization. Mod Pathol. 2007; 20(3): 389-396. doi: 10.1038/modpathol.3800753

 

14. Chang C, Hung H, Chang J, Yu CH, Wang Y, Liu B, Chiang C. Central ossifying fibroma: clinicopathologic study of 28 cases. J Formos Med Assoc. 2008; 107(4): 288-294. doi: 10.1016/S0929-6646(08)60089-3

 

15. Del-Hoyo JA, Sanroman JF, Bueno PR, Gonzales FJD, Usandizaga JLGD, Gil FM, Gias LN, Lopez AC, Cardozo RM. Primary mandibular reconstruction with bridging plates. J Cranio-Maxillofac Surg. 1994; 22(1): 43-48. doi: 10.1016/S1010-5182(05)80295-1

 

16. Stosic S. Mandibular reconstruction state of the art and perspectives. Vojnosanit Pregel. 2008; 65(5): 397-403. doi: 10.2298/vsp0805397s

 

17. Elsalanty ME and Genecov DG. Bone graft in craniofacial surgery. Craniomaxillofac Trauma Recons. 2009; 2(3): 125-134.  doi: 10.1055/s-0029-1215875

 

18. Hong C, Quach A, Lin L, Olson J, Kwon T, Bezouglaia O, Tran J, Hoang M, Bui K, Kim RH, Tetradis S. Local vs systemic administration of biphosphonates in rat cleft bone graft: a comparative study. PLoS One. 2018; 13(1): e0190901.  doi: 10.1371/journal.pone.0190901

 

19. Shaw NJ, Bishop NJ. Bisphosphonate treatment of bone disease. Arch Dis Child. 2005; 90(5): 494-499.  doi: 10.1136/adc.2003.036590

 

20. Mathijssen NM, Buma P, Hannink G. Combining bisphosphonates with allograft bone for implant fixation. Cell Tissue Bank. 2014; 15(3): 329-36.  doi: 10.1007/s10561-013-9416-7

 

21. Jakobsen T, Baas J, Bechtold J. The effect of soaking allograft in bisphosphonate: a pilot dose-response study. Clin Orthop Relat Res. 2010; 468(3): 867-874.  doi: 10.1007/s11999-009-1099-9

 

22. Lozano-Carrascal N, Salomo-Coll O, Hernandez-Alfaro F, Gehrke SA, GargalloAlbiol J, Calvo-Guirado JL. Do topical applications of biphosphonates improve bone formation in oral implantology? a systematic review. Med Oral Patol Oral Cir Bucal. 2017; 22(4): e512-e519.  doi: 10.4317/medoral.21887.



DOI: https://doi.org/10.22146/majkedgiind.45096

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