Pengaruh Level HBA1C Terhadap Fungsi Fagositosis Neutrofil (PMN) pada Penderita Periodontitis Diabetika

https://doi.org/10.22146/majkedgiind.9375

Ahmad Syaify(1*)

(1) Bagian Periodonsia, Fakultas Kedokteran Gigi. Universitas Gadjah Mada. Yogyakarta
(*) Corresponding Author

Abstract


Latar belakang. Diabetes Melitus (DM) merupakan penyakit sistemik yang sangat terkait dengan meningkatnya keparahan penyakit periodontal. Pada penderita DM diduga kuat bahwa keparahan periodontitis disebabkan oleh gangguan fungsi leukosit. Sel neutrofil (PMN) diketahui berperan besar di dalam system pertahanan jaringan periodontal. Kontrol glikemik pada penderita DM dapat diketahui dengan pemeriksaan level HbA1c. Tujuan. Penelitian ini untuk mengetahui pengaruh level HbA1c pada penderita periodontitis diabetika terhadap fungsi fagositosis sel PMN. Bahan dan Cara. Sel PMN dari darah tepi 15 pasien periodontitis terdiri 5 periodontitis tana DM, 5 periodontitis diabetika terkontrol (HbA1c<7) dan 5 periodontitis diabetika tidak terkontrol (HbA1C>7) diuji aktivitas fagositosinya dengan partikel lateks. Fungsi fagositosis dihitung dengan rumus indeks fagositosis (IF). Hasil. Terdapat perbedaan significant IF sel PMN subyek periodontitis diabetika tidak terkontrol (HbA1c>7) dengan periodontitis non DM. IF tertinggi pada subyek periodontitis non DM dan tertinggi pada periodontitis diabetika tidak terkontrol (HbA1c>7). Kesimpulan. Level HbA1c berpengaruh terhadap fungsi fagositosis sel PMN yang dilihat dari indeks fagositosis (IF). 

 

Background. Diabetes mellitus is a systemic condition that has long been associated with an increased and severity of periodontal disease. The severity of periodontitis in diabetic patients was thought caused by decreation of leukocytes function. Polymorphonuclear leukocytes (PMN) play a key role in the maintenance of gingival (HbA1c) level. Aims. The objective of this study was to analyse the influence of HbA1C level to fagositosis index on diabetic periodontitis patients. Material and Methods. PMN were taken from peripheral blood of 15 periodontitis patients consisted of 5 subject with uncontrolled DM (HbA1c>7), 5 subject with controlled DM (HbA1c<7), and 5 subject non DM as control. Phagocytosis function were determined using latex particle and coaunted by phagocytosis index (PI). Results. These analysis revealed a significant (p<0.05) different of PI between diabetic periodontitis who have HbA1c>7 and periodontitis non diabetic subjects. The higest PI was on diabetic periodontitis with HbA1c level >7 and the lowest PI was on non diabetic subjects. Conclusion. Level of HbA1c on diabetic periodontitis patient influence to phagocytosis function of PMN.


Keywords


Periodontitis diabetika; sel PMN; Tungsi Fagositosis; diabetic periodontitis; PMN cell; phagocytosis function

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DOI: https://doi.org/10.22146/majkedgiind.9375

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