Efek merokok konvensional dan elektrik terhadap kadar hormon kortisol saliva
Virta Devi Kartika Putri(1), Heni Susilowati(2), Juni Handajani(3*)
(1) Program Studi Pendidikan Dokter Gigi, Fakultas Kedokteran Gigi, Universitas Gadjah Mada, Yogyakarta
(2) Departemen Biologi Oral, Fakultas Kedokteran Gigi, Universitas Gadjah Mada, Yogyakarta
(3) Departemen Biologi Oral, Fakultas Kedokteran Gigi, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author
Abstract
Rokok konvensional menghasilkan asap atau aerosol padat dan rokok elektrik menghasilkan aerosol cair. Nikotin dari kedua jenis rokok tersebut diduga dapat mempengaruhi kadar hormon kortisol dalam saliva melalui respon autonomic nervous system (ANS) yang disertai aktivasi hypothalamic-pituitary-adrenal axis. Tujuan penelitian ini adalah untuk mengetahui pengaruh antara merokok konvensional dibandingkan dengan elektrik terhadap kadar hormon kortisol dalam saliva. Subjek sebanyak 18 laki-laki perokok terdiri dari 9 perokok konvensional dan 9 perokok elektrik, usia 2030 tahun. Pengambilan sampel saliva pada pukul 12.00 WIB. Uji kadar kortisol dalam saliva menggunakan ELISA kit (RnD Systems) dengan Panjang gelombang 450 nm. Perbandingan rerata kadar kortisol saliva perokok konvensional dan perokok elektrik dianalisis dengan menggunakan uji t tidak berpasangan. Hasil penelitian mengindikasikan bahwa kadar hormon kortisol dalam saliva perokok konvensional lebih tinggi daripada perokok elektrik, meskipun perbedaan tersebut tidak bermakna (p>0,05). Disimpulkan bahwa tidak terdapat perbedaan antara kadar kortisol saliva perokok konvensional dengan perokok elektrik.
Keywords
Full Text:
PDFReferences
Manjunatha BS. Textbook of dental anatomy and oral physiology: including occlusion and forensic odontology. New Delhi: Jaypee Brothers Medical Publishers; 2013. 226-228, 238.
Ongole R, Praveen BN. Textbook of oral medicine, oral diagnosis and oral radiology Edisi 2. New Delhi: Elsevier; 2013. 267-268, 278, 553.
Gaw A, Murphy MJ, Srivastava R, Cowan RA, O’Reilly D, St. J. Clinical Biochemistry: An Illustrated Colour Text Edisi 5. Edinburgh: Elsevier; 2013. 94.
LeVert S. The facts about nicotine. New York: Marshall Cavendish; 2007. 23-25, 32-36.
Farsalinos KE. “Introduction to e-Cigarettes”. Brian F. Thomas (ed.). Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles. Amsterdam: Elsevier; 2017. 1-4, 6.
Gillman IG. “Analytical Testing of e-Cigarette Aerosol”. Brian F. Thomas (ed.). Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles. Amsterdam: Elsevier; 2017. 25-26.
Farsalinos KE, Spryou A, Tsimopoulou K, Stefopoulos C, Romagna G, Voudris V. Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices. Scientific Reports. 2014; 4(4133): 1-7.
Silagy C, Lancaster T, Stead L, Mant D, Fowler G. Nicotine replacement therapy for smoking cessation. Cochrane Database of Systemic Reviews. 2004; 2004(3): 1-109.
Benowitz NL, Jacob P, Savanapridi C. Determinant of nicotine intake while chewing nicotine polacrilex gum. Clinical Pharmacology and Therapeutics. 1987; 41(4): 467-473.
Contrada RJ, Baum A. The Handbook of Stress Science: Biology, Psychology, and Health. New York: Springer Publishing Company; 2011. 287.
Marshall M. OCR Psychology Component 3: Applied Psychology. Banbury: Hodder Education; 2016.
Hannon RA, Pooler C, Porth CM. Porth Pathophysiology: Concepts of Altered Health States. Philadelphia: Lippincott Williams & Wilkins; 2009. 998.
Hellhammer DH, Wüst S, Kudielka BM. Salivary cortisol as a biomarker in stress research. Psychoneuroendocrinology. 2009; 34(2): 163-171.
Fehrenbach MJ, Herring SW. Illustrated Anatomy of the Head and Neck Edisi 4. St. Louis: Elsevier Saunders; 2012. 157, 170.
Notoatmodjo S. Metodologi Penelitian Kesehatan. Jakarta: Rineka Cipta; 2010.
Pagana KD, Pagana TJ, Pagana TN. Mosby’s Diagnostic and Laboratory Test Reference Edisi 13. St. Louis: Elsevier; 2017. 282-284.
White D. The Hormone Makeover. USA: Xulon Press; 2010. 169.
Rifai N, Horvath AR, Wittwer CT. The Fundamentals of Clinical Chemistry and Molecular Diagnostics Edisi 8. St. Louis: Elsevier; 2019. 46.
Wong JA, Pickworth WB, Waters AJ, al’Absi M, Leventhal AM. Cortisol levels decrease after acute tobacco abstinence in regular smokers. Human Psychopharmacology. 2014; 29(2): 152-162.
Rifai N, Horvath AR, Wittwer CT. The Fundamentals of Clinical Chemistry and Molecular Diagnostics Edisi 8. St. Louis: Elsevier; 2019. 46.
Greenblatt JM, Brogan K. Integrative Therapies for Depression: Redefining Models for Assessment, Treatment, and Prevention. Boca Raton: CRC Press; 2016. 176.
Zhang Q-L, Baumert J, Ladwig K-H, Wichmann H-E, Meisinger C, Döring A. Association of daily tar and nicotine intake with incident myocardial infarction: results from the population-based MONICA/KORA Augsburg Cohort Study 1984-2002. BioMed Central Public Health. 2011; 11(273): 1-9.
Pichelstorfer L, Hofmann W, Winkler-Heil R, Yurteri CU, McAughey J. Simulation of aerosol dynamics and deposition of combustible and electronic cigarette aerosols in the human respiratory tract. Journal of Aerosol Science. 2016; 99: 125-132.
Lee AKY, Ling TY, Chan CK. Understanding hygroscopic growth and phase transformation of aerosols using single particle raman spectroscopy in an electrodynamic balance. Faraday Discussions. 2008; 137: 245-263.
Wilkins JN, Carlson HE, Vunakis HV, Hill MA, Gritz E, Jarvik ME. Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers. Psychopharmacology. 1982; 78(4): 305-308.
Raftery AT, Delbridge MS, Douglas HE. Basic science for the MRCS: A Revision Guide for Surgical Trainees Edisi 2. Edinburgh: Elsevier; 2012. 227, 262.
DOI: https://doi.org/10.22146/mkgk.76282
Article Metrics
Abstract views : 1194 | views : 3371Refbacks
- There are currently no refbacks.
Copyright (c) 2022 MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.