The pharmacokinetics of cefepime in various health conditions: a review article

Venansi Viktaria; Dyah Kusumasari; Saifa Usni Putri; Shaula Chintyasari; Mustofa

doi:10.22146/ijpther.15937

Venansi Viktaria Magister Programme of Biomedical Science, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Indonesia https://orcid.org/0000-0002-1262-2558
Dyah Kusumasari Magister Programme of Biomedical Science, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Indonesia
Saifa Usni Putri Magister Programme of Biomedical Science, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Indonesia https://orcid.org/0000-0002-7688-2930
Shaula Chintyasari Magister Programme of Biomedical Science, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Indonesia
Mustofa Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Indonesia https://orcid.org/0000-0003-0243-6097

DOI: https://doi.org/10.22146/ijpther.15937

Keywords: Cefepime, pharmacokinetics profile, ADME, cephalosporin, antibiotics

Abstract

Cefepime is one of fourth-generation cephalosporins which has been proven to have activity against a wide spectrum of Gram-positive and Gram-negative bacterias. It induces lysis in bacterias by disrupting the cell wall synthesis. In this review, we presented the pharmacokinetic profile cefepime in subjects with various health
conditions, such as in healthy adults, in patients with hematological malignancies, in critically ill patients, as well as in patients with renal impairment. According to various studies, such conditions could alter the pharmacokinetic profile of cefepime, especially on the excretion profile. Nevertheless, it is concluded that
cefepime could still be given all subjects, either with and without underlying conditions.