Antibiotic use at the ear, nose, and throat outpatient clinic in Bangli Regional Hospital, Bali
Abstract
Ear, nose, and throat (ENT) diseases are defined as diseases that occur around the ear, nose, and throat organs, which do not recognize seasons and can affect various ages. The prevalence of ENT diseases in Indonesia is quite high, with the most common therapy being antibiotics. Irrational antibiotics use can lead to increased treatment costs, risk of side effects, and toxicity. This study aimed to evaluate the use of antibiotics among ENT outpatient. This was a cross-sectional study using medical records data from the ENT Outpatient Clinic in Bangli Regional Hospital in 2022 that meet the inclusion criteria. Data were analyzed descriptively and presented in tables or diagrams. A total of 80 samples were evaluated, predominantly aged 18-44 yo (60%), female (53.8%), and diagnosed with chronic suppurative otitis media (20%). The pattern of antibiotic prescription consisted of monotherapy antibiotics (62.5%) in solid dosage forms (58.8%), administered orally (60%), and with a duration of administration ≥ 5 d (82.5%). Patients aged 18-44 yr, both male and female, receiving either monotherapy or
polytherapy antibiotics were predominantly cases of infection (>90%). The results of this study are expected to serve as one of the sources of information for the development of practical clinical guidelines for ENT patients receiving antibiotic therapy, particularly at the Bangli Regional Hospital, Bali.
References
Muktar M, Rahmayau M, Sudrajat B. Sistem pakar diagnosa penyakit tht berbasis web dengan menggunakan metode certainty factor. J Inov Inform Univ Pradita 2020; 8(2):45-54
https://doi.org/10.51170/jii.v5i1.33
Setyaputri KE, Fadlil A, Sunardi S. Analisis metode certainty factor pada sistem pakar diagnosa penyakit THT. JTE 2018; 10(1):30-5.
https://doi.org/10.15294/jte.v10i1.14031
Dirgantara B, Hairani H. Sistem pakar diagnosa penyakit THT menggunakan inferensi forward chaining dan metode certainty factor. BITe 2021; 3(1):1-8.
https://doi.org/10.30812/bite.v3i1.1241
Suprayitno B, Susianti, Suharmanto. Pola penyakit di poliklinik telinga hidung dan tenggorok bedah kepala leher (THT-KL) RSUD Ragab Begawe Caram Mesuji. JIKK 2021; 8(2):120-9.
https://doi.org/10.33024/jikk.v8i2.4271
Agustina YS, Megantara I, Dermawan A. Pattern of bacteria, antibiotic uses and sensitivity among ear, nose, and throat infectious disease in otolaryngology ward in tertiary hospital. IJIHS 2019; 7(1):39-47.
Institute for Health Metrics and Evaluation. Global bacterial antimicrobial resistance burden estimates 2019 [Internet]. Institute for Health Metrics and Evaluation (IHME). 2022. p. 1-4.
Aalasyam N, Potnuru S, Sileveru CM, Pokala U, Naveen P. Antimicrobial prescription pattern in ENT Outpatient Department in a Tertiary Care Teaching Hospital, Telangana, India. IJRSMS 2023; 0(October):1-7.
https://doi.org/10.1055/s-0043-1761502
Arora R, Upadhyay S, Singh H, Bajpai A. Drug utilization pattern of antimicrobial agent used in ear, nose and throat outpatient and inpatient department at tertiary care teaching centre. Int J Otorhinolaryngol Head Neck Surg 2020; 6(2):369.
https://doi.org/10.18203/issn.2454-5929.ijohns20200153
Taher P, Oktanauli P, Anggraini SR. Rasionalitas penggunaan antibiotika pada pasien poli gigi salah satu rumah sakit pendidikan di Jakarta. JITEKGI 2021; 16(2):51-6.
https://doi.org/10.32509/jitekgi.v16i2.1092
Artono, Surayya R, Purnami N, Handoko E. Microbiological profile with antibiotic sensitivity pattern for chronic suppurative otitis media in a tertiary hospital, Indonesia. Res J Pharm Technol 2022; 15(4):1683-8.
https://doi.org/10.52711/0974-360X.2022.00282
Gupta TK, Kasaudhan SM, Paudyal V, Bharati P, Hamal K. Patterns of ent problems under general practice in rural hospital of high altitude. JCMC 2023; 13(1):2-5.
https://doi.org/10.54530/jcmc.1266
Giri A, Pokharel A, Palikhey A, Upadhyay HP, Giri BL. Prescribing pattern of antibiotics in ENT outpatients of tertiary care hospital in Bharatpur, Nepal. JCMS 2022; 18(3):254-60.
https://doi.org/10.3126/jcmsn.v18i3.47444
Pallavi I, Roshani S, Amita S, Prabhakar Singh. Prescribe pattern of drugs and antimicrobials preferences in the department of ENT at tertiary care SGM hospital, Rewa, MP, India. J Pharm Biomed Sci 2016; 6(2):89-93.
Sajjad U, Afzal N, Asif M, Rehman MB, Afridi AU, Kazmi T. Evaluation of antibiotic prescription patterns using WHO AWaRe classification. East Mediterr Health J 2024; 30(2):156-62.
https://doi.org/10.26719/emhj.24.031
Srinivasa J, Rajendran V, Nadig P, Swany S. Prescribing pattern of antibiotics in ENT outpatient department in a tertiary care teaching hospital. Int J Basic Clin Pharmacol 2024; 13(5):642-6.
https://doi.org/10.18203/2319-2003.ijbcp20242422
Syopyanah Sri Puspa, Nasaruddin H, Arifuddin ATS, Pratama AA, Syamsu Rijal. Karakteristik pasien otitis media supuratif kronik di Rumah Sakit Ibnu Sina Makassar periode Juni 2018 - Desember 2021. Fakumi Med J 2023; 3(3):199-208.
https://doi.org/10.33096/fmj.v3i3.221
Apriliasari NKV, Permatananda PANK, Siadja AA. Karakteristik pasien otitis media akut di RSUD Sanjiwani Gianyar Tahun 2021. Aesculapius Med J 2024; 4(2):1-7.
https://doi.org/10.22225/amj.4.2.2024.150-156
Salim QM, Adnan A, Adriztina I, Winanto ID. Prevalence and profile of patients with otitis externa at the Universitas Sumatera Utara Hospital in Medan in 2020-2021. Bul Farmatera 2023; 8(1):73-83.
https://doi.org/10.30596/bf.v8i1.13101
Isaac S, Jayakumari S, Sree Lekshmi RS. A prospective study on the drug prescribing pattern of antibiotics in the ears, nose and throat department of a tertiary care hospital. RJPT 2019; 12(12):6001-6.
https://doi.org/10.5958/0974-360X.2019.01041.2
Nazirah J, Putri BI, Maulina N, Herlina N, Fauzan A. Manajemen epistaksis. GALENICAL 2024; 3(1):55.
https://doi.org/10.29103/jkkmm.v3i1.14853
Ratunanda SS, Satriyo JI, Samiadi D, Madiadipoera T, Anggraeni R. Efektivitas terapi kortikosteroid intranasal pada hipertrofi adenoid usia dewasa berdasarkan pemeriksaan narrow band imaging. MKB 2019; 48(4):228-33.
https://doi.org/10.15395/mkb.v48n4.914
Santosa A, Permatananda PANK, Putra IPWE. Hubungan hipertensi dengan kejadian presbikusis di Poliklinik THT-KL RSUP Sanglah Denpasar. Intisar Sains Med 2022; 13(3):718-21.
Karataş M, Akgün S, Doğan S, Turğut M, Çalış N. Evaluation of the surface and the core cultures of adenoids in patients with recurrent adenotonsillitis, obstructive adenoid hypertrophy, and otitis media with effusion. J Clin Med Kaz 2021; 18(1):38-43.
https://doi.org/10.23950/jcmk/9652
Purnasari C, Manggau MA, Kasim H. Studi pengaruh dosis dan lama penggunaan terapi aminoglikosida terhadap fungsi ginjal. Maj Farm Farmakol 2018; 22(3):76-80.
https://doi.org/10.20956/mff.v22i3.5807
Patel DA, Pillai A, Gohil UM. A study of antimicrobial prescription pattern in the ear, nose and throat at a tertiary care teaching hospital, Rajkot. IJPSR 2018; 9(9):3960.
Fauziah H, Mulyana R, Martini RD. Polifarmasi pada pasien geriatri. Human Care J 2020; 5(3):804.
https://doi.org/10.32883/hcj.v5i3.796
Permatananda PANK, Apsari PIB, Aryastuti AASA. Drug prescribing evaluation to foreign travelers in Bali: a study of two travel clinics. RJPT 2024; 17(8):3881-4.
https://doi.org/10.52711/0974-360X.2024.00602
Grant J, Saux NL; members of the Antimicrobial Stewardship and Resistance Committee (ASRC) of the Association of Medical Microbiology and Infectious Disease (AMMI) Canada. Duration of antibiotic therapy for common infections. Infect Dis Can 2021; 6(3):181-97.
https://doi.org/10.3138/jammi-2021-04-29
Imama LA, Susilowati E. Profil peresepan antibiotik pada pasien rawat jalan di Puskesmas Ardimulyo Kabupaten Malang. Malang: Akademi Farmasi Putra Indonesia; 2020.
Pulia MS, Keller SC, Crnich CJ, Jump RLP, Yoshikawa TT, Hopkins J, et al. Antibiotic stewardship for older adults in ambulatory care settings: addresing an unmet challenge. J Am Geriatr Soc 2021; 68(2):244-9.
https://doi.org/10.1111/jgs.16256
Sari WK, Advitasari YD, Elisa N. Pola peresepan antibiotik untuk pengobatan infeksi saluran pernafasan atas (ISPA) di klinik X Kota Semarang. CJP 2024; 8(1):17-27.
https://doi.org/10.31596/cjp.v8i1.275
Pradina NU, Hanifa DNC. Gambaran kesesuaian peresepan antibiotik pada pasien dewasa Nindya. Borneo Stud Res 2022; 3(2):2217-26.
Sigdel B, Dubey T, Nepali R, KC N. Prescription patterns of antibiotics in acute tonsillitis: hospital-based study. J-GMC-N 2020; 13(1):65-7.
https://doi.org/10.3126/jgmcn.v13i1.27561
Permatananda PANK, Widhidewi NW. Penggunaan antibiotik empiris pada pasien pneumonia. Medika Respati: J Ilm Kes 2021; 16(4):249-56.
https://doi.org/10.35842/mr.v16i4.468
Permatananda PA, Pandit PA. The outcome difference of monotherapy versus combination therapy among patients with pneumonia: a systematic review. Minerva Med 2025; 116(2):135-40.
