Potential of orchid as antifungal agent resources: a scoping review
Abstract
In 2017, one billion people contracted fungal infection with 11.5 million people contracted life-threatening infection and 1.5 million death per year. Orchid is a plant that grows in tropical and sub-tropical countries, the same places where fungal infection occurrence is high. On previous studies reported that orchid contains alkaloids and polyphenols such as flavonoid, and phenol acid. The review aimed to identify the orchid as a potential antifungal resource. A scoping review was used. The type of articles reviewed were original articles obtained from five electronic journal databases published within 2012-2021. Three articles reported similar result which was that orchid extract has a significant antifungal activity although the part of plant used was different, ranging from the root, to the leaf. Two articles reported a specific antifungal activity against Candida albicans while the remaining one against Trichophyton rubrum. In conclusion, the root, leaf, branch, and flower extracts of orchid is potential antifungal resources.
References
Gandjar I, O. Sjamsuridzal W, Ariyanti. Mikologi dasar dan terapan. Jakarta: Gramedia Pustaka; 2006.
Nagaral GV, Goud GKV, Sudha PJ. Prevalence of tinea corporis and tinea cruris in Chitradurga rural population. IP Indian J Clin Exp Dermatol 2018; 4(3):221-5.
https://doi.org/10.18231/2581-4729.2018.0047
Irmayanti VA, Izhar D. Hubungan pengetahuan, personal higien, dan sumber air bersih dengan gejala penyakit kulit jamur di Kelurahan Rantau Indah Wilayah Kerja Puskesmas Dendang, Kabupaten Tanjung Jabung Timur tahun 2013. Sci J 2013; 2(2):79-85.
Tudela JLR, Denning DW. Recovery from serious fungal infections should be realisable for everyone. Lancet Infect Dis 2017; 17(11):1111-3.
https://doi.org/10.1016/S1473-3099(17)30319-5
Wang X, Ding C, Xu Y, Yu H, Zhang S, Yang C. Analysis on the pathogenic fungi in patients with superficial mycosis in the Northeastern China during 10 years. Exp Ther Med 2020; 20(6):281.
https://doi.org/10.3892/etm.2020.9411
Shields BE, Rosenbach M, Brown-Joel Z, Berger AP, Ford BA, Wanat KA. Angioinvasive fungal infections impacting the skin: Background, epidemiology, and clinical presentation. J Am Acad Dermatol 2019; 80(4):869-80.e5.
https://doi.org/10.1016/j.jaad.2018.04.059
Gatot D. Infeksi jamur sistemik pada pasien immunocompromised. Sari Pediatri 2016; 3(4):242.
http://dx.doi.org/10.14238/sp3.4.2002.242-6
Ameen M. Epidemiology of superficial fungal infections. Clin Dermatol 2010; 28(2):197-201.
http://dx.doi.org/10.1016/j.clindermatol.2009.12.005
Rosida F, Ervianti E. Retrospective study: superficial mycoses. Berkala Ilmu Kesehat Kulit dan Kelamin 2017; 29:117–25.
http://dx.doi.org/10.20473/bikk.V29.2.2017.117-125
Blutfield MS, Lohre JM, Pawich DA, Vlahovic TC. The immunologic response to trichophyton rubrum in lower extremity fungal infections. J Fungi 2015; 1(2):130-7.
https://doi.org/10.3390/jof1020130
Peres NTDA, Rossi A, Maranhão FCA, Martinez-Rossi NM. Dermatophytes: host-pathogen interaction and antifungal resistance. An Bras Dermatol 2010; 85(5):657-67.
https://doi.org/10.1590/s0365-05962010000500009
Rautemaa-Richardson R, Richardson MD. Systemic fungal infections. Medicine (United Kingdom) 2017; 45(12):757-62.
https://doi.org/10.1016/j.mpmed.2017.09.007
Lockhart SR, Guarner J. Emerging and reemerging fungal infections. Semin Diagn Pathol 2019; 36(3):177-81.
https://doi.org/10.1053/j.semdp.2019.04.010
Limper AH, Adenis A, Le T, Harrison TS. Fungal infections in HIV/AIDS. Lancet Infect Dis 2017; 17(11):e334-43.
http://dx.doi.org/10.1016/S1473-3099(17)30303-1
McCarty TP, Pappas PG. Invasive candidiasis. Infect Dis Clin North Am 2016; 30(1):103-24.
http://dx.doi.org/10.1016/j.idc.2015.10.013
Brooks GF. Mikrobiologi kedokteran Jawetz, Melnick, & Adelberg. EGC. 2013.
Biswas SK, Chaffin WLJ. Anaerobic growth of Candida albicans does not support biofilm formation under similar conditions used for aerobic biofilm. Curr Microbiol 2005; 51(2):100-4.
https://doi.org/10.1007/s00284-005-4552-3
Peron IH, Reichert-Lima F, Busso-Lopes AF, Nagasako CK, Lyra L, Moretti ML, et al. Resistance surveillance in Candida albicans: a five-year antifungal susceptibility evaluation in a Brazilian University Hospital. PLoS One 2016; 11(7):0158126.
https://doi.org/10.1371/journal.pone.0158126
Schwartz S, Kontoyiannis DP, Harrison T, Ruhnke M. Advances in the diagnosis and treatment of fungal infections of the CNS. Lancet Neurol 2018; 17(4):362-72.
http://doi.org/10.1016/S1474-4422(18)30030-9
Kim JY. Human fungal pathogens: why should we learn? J Microbiol 2016; 54(3):145-8.
https://doi.org/10.1007/s12275-016-0647-8
Caceres A, Avila ML, Herrera ML. Fungal infections in pediatric neurosurgery. Childs Nerv Syst 2018; 34(10):1973-88.
https://doi.org/10.1007/s00381-018-3942-3
Apsari AS, Adiguna MS. Resistensi antijamur dan strategi untuk mengatasi. J Media Dermato Venerologica Indones 2013; 40(2):89-95.
Girois SB, Chapuis F, Decullier E, Revol BGP. Adverse effects of antifungal therapies in invasive fungal infections: review and meta-analysis. Eur J Clin Microbiol Infect Dis 2006; 25(2):138-49.
https://doi.org/10.1007/s10096-005-0080-0
Sari LORK. Pemanfaatan obat tradisional dengan pertimbangan manfaat dan keamanannya. Majalah Ilmu Kefarmasian 2006; 3(1):1-7.
https://doi.org/10.7454/psr.v3i1.3394
Supardi S, Susyanty AL. Penggunaan obat tradisional dalam upaya pengobatan sendiri di Indonesia. Pusat Penelitian, Pengembangan Sistem dan Kebijakan Kesehatan Jakarta. 2010;
Paradiso R, Pascale SD. Effects of plant size, temperature, and light intensity on flowering of phalaenopsis hybrids in Mediterranean greenhouses. Sci World J 2014; 2014:420807.
https://doi.org/10.1155/2014/420807
Gutiérrez RMP. Orchids: a review of uses in traditional medicine, its phytochemistry and pharmacology. J Med Plants Res 2010; 4(8):592-638.
https://doi.org/10.5897/JMPR10.012
Elansary HO, Salem MZM, Ashmawy NA, Yessoufou K, El-Settawy AAA. In vitro antibacterial, antifungal and antioxidant activities of Eucalyptus spp. leaf extracts related to phenolic composition. Nat Prod Res 2017; 31(24):2927-30.
http://doi.org/10.1080/14786419.2017.1303698
Dhamgaye S, Devaux F, Vandeputte P, Khandelwal NK, Sanglard D, Mukhopadhyay G, et al. Molecular mechanisms of action of herbal antifungal alkaloid berberine, in Candida albicans. Plos One 2014; 9(8):104554.
https://doi.org/10.1371/journal.pone.0104554
Kukula-Koch WA, Widelski J. Alkaloids. In: Mccreath SB and Delgoda R editors. Pharmacognosy: fundamentals, applications and strategy 1st eds. Elsevier Inc.; 2017. 163-8.
http://doi.org/10.1016/B978-0-12-802104-0.00009-3
Bitencourt TA, TakahasiKomoto T, Marins M, Fachin AL. Antifungal activity of flavonoids and modulation of expression of genes of fatty acid synthesis in the dermatophyte Trichophyton rubrum. BMC Proc 2014; 8(Suppl 4):P53.
https://doi.org/10.1186/1753-6561-8-S4-P53
Lima NM, Cursino-Hron LM, Lima AM, Souza JVB, de Oliveira AC, Marinho JVN, et al. Antifungal activity of extracts and phenolic compounds from Deguelia duckeana. Brazilian J Pharmacogn 2018;28(6):697-702.
https://doi.org/10.1016/j.bjp.2018.08.004
Wang XL, Liu D, Xia YM, Cao XP, Pan XF. Ramberg backlund rearrangement approaches to the synthesis of natural bibenzyls. Chinese J Chem 2004; 22(5):467-72.
https://doi.org/10.1002/cjoc.20040220515
Kovács A, Vasas A, Hohmann J. Natural phenanthrenes and their biological activity. Phytochemistry 2008; 69(5):1084-110.
https://doi.org/10.1016/j.phytochem.2007.12.005
Yoshikawa K, Ito T, Iseki K, Baba C, Imagawa H, Yagi Y, et al. Phenanthrene derivatives from Cymbidium great flower marie laurencin and their biological activities. J Nat Prod 2012; 75(4):605-9.
https://doi.org/ 10.1021/np200788u
Yang W, Chen X, Li Y, Guo S, Wang Z, Yu X. Advances in pharmacological activities of terpenoids. Nat Prod Commun 2020; 15(3):1-13.
https://doi.org/10.1177/1934578X20903555
Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. Ann Intern Med 2018; 169(7):467-73.
https://doi.org/10.7326/M18-0850
Peters MDJ, Godfrey CM, Khalil H, McInerney P, Parker D, Soares CB. Guidance for conducting systematic scoping reviews. Int J Evid Based Healthc 2015; 13(3):141-6.
https://doi.org/10.1097/XEB.0000000000000050
Passavanti MB, Alfieri A, Caterina Pace M, Pota V, Sansone P, Piccinno G, et al. Clinical applications of palmitoylethanolamide in pain management: protocol for a scoping review. Sys Rev 2020; 8(1):9.
https://doi.org/10.1186/s13643-018-0934-z
Yoshikawa K, Baba C, Iseki K, Ito T, Asakawa Y, Kawano S, et al. Phenanthrene and phenylpropanoid constituents from the roots of Cymbidium Great Flower “Marylaurencin” and their antimicrobial activity. J Nat Med 2014; 68(4):743-7.
https://doi.org/10.1007/s11418-014-0854-8
Fang YS, Yang MH, Cai L, Wang JP, Yin TP, Yu J, et al. New phenylpropanoids from Bulbophyllum retusiusculum. Arch Pharm Res 2018; 41(11):1074-81.
https://doi.org/10.1007/s12272-018-1067-6
Cretton S, Oyarzún A, Righi D, Sahib L, Kaiser M, Christen P, et al. A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea. Nat Prod Res 2017; 32(6):695-701.
https://doi.org/10.1080/14786419.2017.1338287
Zhang QW, Lin LG, Ye WC. Techniques for extraction and isolation of natural products: a comprehensive review. Chinese Med 2018; 13:20.
https://doi.org/10.1186/s13020-018-0177-x
Roge AB, Firke SN, Kawade RM, Sarje SK, Vadvalkar SM. Brief review on: flash chromatography a. IJPSR 2011; 2(8):1930-7.
https://doi.org/10.13040/IJPSR.0975-8232.2(8).1930-37
Stevens WC, Hill DC. General methods for flash chromatography using disposable columns. Mol Divers 2009; 13(2):247-52.
https://doi.org/ 10.1007/s11030-008-9104-x
