Indonesian Journal of Pharmacology and Therapy

Knowledge, attitude, and practice on antibiotic use in DKI Jakarta during COVID-19 pandemic

2025-04-11T09:44:47+07:00

Insufficient knowledge of antibiotic use among the general public could lead to antibiotic resistance. As the COVID-19 pandemic might encourage antibiotic self-medication, a study about recent knowledge, attitude, and practice (KAP) levels on antibiotic use during the COVID-19 pandemic needs to be carried out, including its possible associated factors. It is a cross-sectional study with 420 subjects living in DKI Jakarta and aged 18 or above. A validated KAPAQ questionnaire was used. Chi-square analysis was used to analyze the correlation between KAP levels and its possible associated factors. Most subjects’ score of KAP in antibiotic use were considered high. A statistically significant correlation between knowledge and attitude (p<0.001), knowledge and practice (p<0.001), and between attitude and practice (p<0.001) was found. A statistically significant correlation between gender and occupation fields with KAP (p<0.05), education level with knowledge (p<0.05), and history of self-medication with attitude and practice (p<0.05) were found. Age, marital status, and history of COVID-19 do not show any statistically significant correlation with KAP levels. In conclusion, most subjects have a high score of KAP in antibiotic use. All three variables also show significant correlations between each other while the sociodemographic factors that correlate significantly with KAP levels are gender, occupation field, education level, and history of self-medication with antibiotics.

The use of cetirizine in allergic contact dermatitis patients at Sekip Palembang Health Center

2025-04-11T09:44:48+07:00

World Allergy Organization (WAO) reported that 22% of the global population experiences allergies, and this prevalence continues to increase each year. The prevalence of dermatitis in Indonesia is quite high, at 6.78%, with the highest rate in South Kalimantan (11.3%) and the lowest in West Sulawesi (2.57%). In South Sumatra, approximately 2,584,000 people suffer from dermatitis. Therapy for allergic contact dermatitis patients includes medicamentous treatments, such as systemic antihistamines, with cetirizine being one of the options. This study aimed to determine the pattern of cetirizine use, including the frequency, duration of administration, and the characteristics of allergic contact dermatitis patients such as gender and age who received cetirizine therapy. The drug utilization study of cetirizine was conducted in December 2021 at the Sekip Palembang Community Health Center, involving 34 out of 49 patients who met the inclusion criteria. The sampling method used was total sampling. The majority of allergic contact dermatitis patients were late elderly individuals, aged 56-65 yr (32.4%), and women (58.8%). Rationality assessment showed good results in terms of diagnosis (100%), indication (100%), duration of drug administration (97.1%), frequency of drug administration (100%), and drug interactions (93.7%). This study hopefully can enhance the effectiveness of cetirizine usage, enabling healthcare providers to prescribe the medication more rationally according to the patients' allergic symptoms.

Oral corticosteroids (OCS), inhaled corticosteroids (ICS), short acting β-2 agonists (SABA), ICS/long acting β-2 agonists (LABA) treatment in pregnancy with asthma: a review

2025-04-11T09:48:14+07:00

Asthma is one of the common pulmonary disorders that can complicate pregnancy. Therefore, managing asthma is crucial for pregnant women's health and the well-being of the embryo. As consequence, it is important to evaluate the effectiveness and integrity of treatment for this usual therapy in expectant mothers with asthma. This review aimed to analyze the efficacy and safety of OCS, ICS, SABA, and ICS/LABA treatment in pregnancy with asthma. The articles were researched from PubMed, Scopus, and Science Direct as literature resources and selection of process based on inclusion criteria. The use of OCS, ICS, SABA, ICS/LABA were safe for pregnancy with asthma, although there are some side effects. In conclusion, the regiment therapy of asthma in asmathic pregnant women is similar to general treatment for asthmatic.