Triglyceride-Glucose Index Associated with Multivessel Artery Coronary Disease (MVCD) Incidents in Patients With Coronary Artery Disease (CAD) at Sultan Agung Islamic Hospital Semarang

Abstract

Background : Coronary artery disease (CAD) patients with multivessel coronary artery disease (MVCD) have higher incidence of major adverse cardiovascular events (MACEs) than patients with single vessel coronary artery disease (SVCD). The triglyceride-glucose index (TG) is a marker of insulin resistance (IR) which has been linked to cardiovascular diseases. However, evidence on the effect of TG index on the incidence of multivessel coronary artery disease (MVCD) in coronary artery disease (CAD) is still limited.

Aims : This study aims to investigate the association between the TG index and the incidence of MVCD in CAD patients at Sultan Agung Islamic Hospital.

Methods : Total of 198 subjects suffering from CAD at Sultan Agung Islamic Hospital Semarang for the period March 2022 to December 2023 were divided into 2 groups, the first group being the MVCD group if the stenosis was ≥ 50% in at least two blood vessels main coronary artery and the second group is the non-multivessel coronary artery disease (non-MVCD) if the stenosis is ≥ 50% in one main coronary artery. This research is an analytical observational study with a cross sectional design. Multivariate test was carried out with a logistic regression test.

Results : The study showed that the higher the TG index value (p=<0.001; PR = 4.117; 95% CI = 2.284-7.424) significantly increased the risk of MVCD in CAD patients.

Conclusions : The increase of TyG index is closely related to the risk of MVCD in CAD patients. This study revealed that the TG index can be a predictor of the severity in CAD patients.     

Keywords: Coronary Artery Disease; Multivessel Coronary Artery Disease; Stenosis; Trigleserid-Glucose Index.