Free Radical Scavenging Activity and Physical Properties of Lip Balm Formulated with Avocado Seed Oil, Virgin Coconut Oil, Tamanu Oil, and Olive Oil

https://doi.org/10.22146/mot.109159

Agitya Resti Erwiyani(1*), Khalisna Ocean(2), Muhammad Rafi Zhafran(3), Istianatus Sunnah(4), Dian Oktianti(5)

(1) Pharmacy Study Program, Universitas Ngudi Waluyo, Semarang, Central Java
(2) Pharmacy Study Program, Universitas Ngudi Waluyo, Semarang, Central Java
(3) Pharmacy Study Program, Universitas Ngudi Waluyo, Semarang, Central Java
(4) Pharmacist Professional Education Study Program, Universitas Ngudi Waluyo, Semarang, Central Java
(5) Pharmacist Professional Education Study Program, Universitas Ngudi Waluyo, Semarang, Central Java
(*) Corresponding Author

Abstract


The lips have fewer layers of corneocytes than the skin and do not contain sebaceous glands and hair follicles, so they are prone to drought. Lip care can be done with the use of lip balm that can protect and maintain lip moisture. The purpose of the study was to evaluate the physical characteristics of lip balm preparations, antioxidant activity as well as GC-MS testing to see the bioactive components in the oil. The results of the qualitative analysis of the oil contain flavonoids, alkaloids, tannins and saponins. Quantitative analysis of GC-MS of avocado seed oil found that the dominant fatty acids were oleic acid, VCO contained the dominant fatty acids of lauric acid, the bioactive tamanu oil was predominant beta-myrcene and olive oil contained the dominant fatty acids of oleic acid. All lip balm formulas have yellowish-white organoleptics, soft and homogeneous texture, have a pH value ranging from 5.07 – 6.88, and melting point ranging from 51 – 52.6 °C.  Lip balm with a ratio of VCO and tamanu oil has moderate antioxidant activity.

Keywords


antioxidant;GC-MS;nabati oil

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References

Amnay, A., & Ouriagli, T. (2022). Evaluation of the Antioxidant Activity of Saponins Extracts in Marrubium vulgare L. Current Developments in Nutrition, 6(September), 502. https://doi.org/10.1093/cdn/nzac077.005

Anggraini, D. I., & Nabillah, L. F. (2018). Activity Test of Suji Leaf Extract (Dracaena angustifolia Roxb.) on in vitro cholesterol lowering Devina. Jurnal Kimia Sains Dan Aplikasi, 21(2), 54–58.

Asiah, N., Astuti, R. M., Cempaka, L., & Setiani, R. (2019). Physical and Chemical Characteristic of Virgin Coconut Oil under Mix Culture Fermentation Technique. Journal of Physics: Conference Series, 1364(1). https://doi.org/10.1088/1742-6596/1364/1/012009

Azizah, R., & Antarti, A. N. (2019). Uji Aktivitas Antibakteri Ekstrak Dan Getah Pelepah Serta Bonggol Pisang Kepok Kuning (Musa paradisiaca Linn.) Terhadap Bakteri Pseudomonas aeruginosa dan Klebsiella pneumoniae Dengan Metode Difusi Agar. JPSCR : Journal of Pharmaceutical Science and Clinical Research, 4(1), 29. https://doi.org/10.20961/jpscr.v4i1.26544

Cao, J., Jiang, X., Chen, Q., Zhang, H., Sun, H., Zhang, W.-M., & Li, C. (2020). Oxidative stabilities of olive and camellia oils: Possible mechanism of aldehydes formation in oleic acid triglyceride at high temperature. Food Science and Technology, 118.

Capriotti, A. L., Cerrato, A., Aita, S. E., Montone, C. M., Piovesana, S., Laganà, A., & Cavaliere, C. (2021). Degradation of the polar lipid and fatty acid molecular species in extra virgin olive oil during storage based on shotgun lipidomics. Journal of Chromatography A, 1639(1).

Cassien, M., Mercier, A., Thétiot-Laurent, S., Culcasi, M., Ricquebourg, E., Asteian, A., Herbette, G., Bianchini, J. P., Raharivelomanana, P., & Pietri, S. (2021). Improving the antioxidant properties of calophyllum inophyllum seed oil from french polynesia: Development and biological applications of resinous ethanol-soluble extracts. Antioxidants, 10(2), 1–23. https://doi.org/10.3390/antiox10020199

Ciftci, O., Ozdemir, I., Tanyildizi, S., Yildiz, S., & Oguzturk, H. (2011). Antioxidative effects of curcumin, β-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver. Toxicology and Industrial Health, 27(5), 447–453. https://doi.org/10.1177/0748233710388452

Dauber, C., Parente, E., Zucca, M. P., Gámbaro, A., & Vieitez, I. (2023). Olea europea and By-Products: Extraction Methods and Cosmetic Applications. Cosmetics, 10(4), 1–21. https://doi.org/10.3390/cosmetics10040112

Folayan, A. J., Anawe, P. A. L., Aladejare, A. E., & Ayeni, A. O. (2019). Experimental investigation of the effect of fatty acids configuration , chain length , branching and degree of unsaturation on biodiesel fuel properties obtained from lauric oils , high-oleic and high-linoleic vegetable oil biomass. Energy Reports, 5, 793–806. https://doi.org/10.1016/j.egyr.2019.06.013

Fonseca, A., Jacob, S. E., & Sindle, A. (2020). Art of prevention: Practical interventions in lip-licking dermatitis. International Journal of Women’s Dermatology, 6(5), 377–380. https://doi.org/10.1016/j.ijwd.2020.06.001

Gorini, I., Iorio, S., Ciliberti, R., Licata, M., & Armocida, G. (2019). Olive oil in pharmacological and cosmetic traditions. Journal of Cosmetic Dermatology, 18(5), 1575–1579. https://doi.org/10.1111/jocd.12838

Grace, X. F., Begam, K. H., Janani, A., & Jayaram, M. (2024). Formulation and Evaluation of Natural Lip Balm. International Journal for Research in Applied Science and Engineering Technology, 11(2), 184–197. https://doi.org/10.22214/ijraset.2024.63489

Gunt, H., & B., S. (2020). Efficacy of a nature-based lip treatment to repair dry damaged lips: Clinical and biophysical assessments. Journal of the American Academy of Dermatology, 83(6).

Jones, J. W., Whiting, Z. G., Gabay, E. M., Rana, M. S., Rutter, M. J., & Reilly, B. K. (2020). Novel use of lip balm under tracheostomy ties to prevent skin irritation in the pediatric patient. International Journal of Pediatric Otorhinolaryngology, 138(November).

Jumina, Siswanta, D., Zulkarnain, A. K., Triono, S., Priatmoko, Yuanita, E., Imawan, A. C., Fatmasari, N., & Nursalim, I. (2019). Development of C-Arylcalix[4]resorcinarenes and C-Arylcalix[4]pyrogallolarenes as Antioxidant and UV-B protector. Indonesian Journal of Chemistry, 19(2), 273–284. https://doi.org/10.22146/ijc.26868

Kardinasari, E., & Devriany, A. (2020). Phytochemical identification of bangka origin virgin green coconut oil: Anti-inflammatory and anti-bacterial potential. Enfermería Clínica, 30(4), 171–174. https://doi.org/10.1016/j.enfcli.2019.10.062

King-Loeza, Y., Cipri´an-Macías, D. A., Cardador-martínez, A., Martín-del-campo, S. T., Castaneda-Saucedo, M. C., & Ramírez-Anaya, J. del P. (2023). Functional composition of avocado (Persea americana Mill. Var Hass) pulp , extra virgin oil , and residues is affected by fruit commercial classification. Journal of Agriculture and Food Research Journal, 12(March), 1–11. https://doi.org/10.1016/j.jafr.2023.100573

Knothe, G., & Dunn, R. O. (2009). A Comprehensive Evaluation of the Melting Points of Fatty Acids and Esters Determined by Differential Scanning Calorimetry. Journal of the American Oil Chemists’ Society, 86(9), 843–856. https://doi.org/10.1007/s11746-009-1423-2

Kursia, S., Fatmawaty, A., & Hafid, M. (2020). The Activity , Formulation and Effectiveness of Liquid Soap Preparations of Arachis hypogaea L . Against Escherichia coli and Staphylococcus aureus. Journal of Pharmaceutical and Medicinal Sciences, 5(2), 48–54.

Lugović-Mihić, L., Pilipović, K., Crnarić, I., Šitum, M., & Duvančić, T. (2018). Differential diagnosis of cheilitis – How to classify cheilitis? Acta Clinica Croatica, 57(2), 342–351. https://doi.org/10.20471/acc.2018.57.02.16

Malavi, D., Nikkhah, A., Raes, K., & Van Haute, S. (2023). Hyperspectral Imaging and Chemometrics for Authentication of Extra Virgin Olive Oil: A Comparative Approach with FTIR, UV-VIS, Raman, and GC-MS. Foods, 12(3). https://doi.org/10.3390/foods12030429

Marwati, E., & Sadik, F. (2023). Perbandingan Proses Ekstraksi Virgin Coconut Oil (VCO). JOPS (Journal Of Pharmacy and Science), 7(1), 83–94. https://doi.org/10.36341/jops.v7i1.3795

Min Oo, W. (2018). Pharmacological Properties of Calophyllum inophyllum. International Journal of Photochemistry and Photobiology, 2(1), 28. https://doi.org/10.11648/j.ijpp.20180201.16

Nurbaiti, N., Fitri, Y., Fitriani, F., Humaira, W., & Triwibowo, C. (2025). Phytochemical Composition and Antioxidant Properties of Avocado (Persea americana) Seed Extract from Aceh , Indonesia : Implications for Antihyperlipidemic Use in Postmenopausal Women. Malacca Pharmaceutics, 3(1), 1–9. https://doi.org/10.60084/mp.v3i1.228

Nurhasnawati, H., Sundu, R., Sapri, Supriningrum, R., Kuspradini, H., & Arung, E. T. (2019). Antioxidant activity, total phenolic and flavonoid content of several indigenous species of ferns in East Kalimantan, Indonesia. Biodiversitas, 20(2), 576–580. https://doi.org/10.13057/BIODIV/D200238

Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016). Flavonoids: An overview. Journal of Nutritional Science, 5. https://doi.org/10.1017/jns.2016.41

Patil, N. J., Pandav, A. S., & Chougule, N. . (2024). Preparation and Evaluation of Herbal Lip Balm. International Journal For Multidisciplinary Research, 6(2), 1–18. https://doi.org/10.36948/ijfmr.2024.v06i02.16030

Prasanna, N. S., Selvakumar, M., Choudhary, N., & Raghavarao, K. S. M. S. (2024). Virgin coconut oil: wet production methods and food applications - a review. Sustainable Food Technology, 2(5), 1391–1408. https://doi.org/10.1039/d4fb00093e

Pribowo, A., Girish, J., Gustiananda, M., Nandhira, R. G., & Hartrianti, P. (2021). Potential of Tamanu (Calophyllum inophyllum) Oil for Atopic Dermatitis Treatment. Evidence-Based Complementary and Alternative Medicine, 2021. https://doi.org/10.1155/2021/6332867

Puspita, S., Nurlaeli, L., Taufiqurrahman, M., & Majid, N. C. (2023). Uji Efektivitas Konsentrasi Minyak Argan (Argania spinosa L.) terhadap Mutu Fisik Sediaan Lip Balm. Jurnal Integrasi Kesehatan & Sains, 5(2), 104–110. https://doi.org/10.29313/jiks.v5i2.11486

Radzimierska-Kazmierczak, M., Smigielski, K., Sikora, M., Nowak, A., Plucinska, A., Kunicka-Styczynska, A., & Czarnecka-Chrebelska, K. H. (2021). Olive oil with ozone-modified properties and its application. Molecules, 26(11), 1–17. https://doi.org/10.3390/molecules26113074

Septiani, R., Anastasia, D. S., & Isnindar. (2024). The Effect of Cocamide DEA on the Characteristics of Ginger and Celery Extract Shampoo Preparations. Majalah Obat Tradisional, 29(3), 249–259. https://doi.org/10.22146/mot.88466

Sharma, K., Kaur, R., Kumar, S., Saini, R. K., Sharma, S., Pawde, S. V., & Kumar, V. (2023). Saponins: A concise review on food related aspects, applications and health implications. Food Chemistry Advances, 2(June 2022), 100191. https://doi.org/10.1016/j.focha.2023.100191

Sholehah, Y. Y., Malahayati, S., & Hakim, A. R. (2022). Formulasi dan Evaluasi Sediaan Lipbalm Ekstrak Umbi Bit Merah (Beta vulgaris L.) Sebagai Antioksidan. Journal Pharmaceutical Care and Sciences, 3(1), 14–26. https://doi.org/10.33859/jpcs.v3i1.205

Soldado, D., Bessa, R. J. B., & Jerónimo, E. (2021). Condensed tannins as antioxidants in ruminants—effective-ness and action mechanisms to improve animal antioxidant status and oxidative stability of products. Animals, 11(11). https://doi.org/10.3390/ani11113243

Sun-Waterhouse, D., Thakorlal, J., & Zhou, J. (2011). Effects of added phenolics on the storage stability of avocado and coconut oils. International Journal of Food Science and Technology, 46(8), 1575–1585.

Tamura, E., Ishikawa, J., Yasuda, Y., & Yamamoto, T. (2021). The efficacy of synthetic pseudo‐ceramide for dry and rough lips. International Journal of Cosmetic Science, 43(2), 158–164.

Tamura, E., Yasumori, H., & Yamamoto, T. (2020). The efficacy of a highly occlusive formulation for dry lips. International Journal of Cosmetic Science, 42(1), 46–52. https://doi.org/10.1111/ics.12583

Tinrat, S. (2021). Phytochemical Screening, Antioxidant and Antimicrobial Assessment of Pluchea indica (L.) Less Extract as an Active Ingredient in Natural Lotion Bar. International Journal of Current Pharmaceutical Research, 13(2).

Visht, S., Salih, S. S., Mohammed, D. A., Abduljabbar, A. A., Hama, S. J., & Khudhair, I. A. (2024). Formulation and Evaluation of Lip Balm Using Different Herbal Pigments. Pharmacognosy Research, 16(2), 367–375. https://doi.org/10.5530/pres.16.2.46

Wickramasinghe Mudiyanselage, D. R., & Wickramasinghe, I. (2023). Comparison of physicochemical characteristics of virgin coconut oils from traditional and hybrid coconut varieties. Journal of Agriculture and Food Research, 12(February), 100554. https://doi.org/10.1016/j.jafr.2023.100554

Yati, K., Dwita, L. P., Oktaviana, L., & Gantini, S. N. (2019). Perbandingan Penggunaan Minyak Zaitun, Vco Dan Minyak Jojoba Terhadap Sifat Fisik Balsem Stick Jintan Hitam (Nigella sativa L.) Dan Aktivitas Antiinflamasi Subakut. Prosiding Kolokium Doktor Dan Seminar Hasil Penelitian Hibah.

Zainodin, E. L., Rashidi, N. F., Abdul Mutalib, H., Ishak, B., & Ghazali, A. R. (2024). Antioxidant Properties of Virgin Coconut Oil and its Cytotoxicity Towards Human Keratinocytes. Natural Product Communications, 19(12). https://doi.org/10.1177/1934578X241309739



DOI: https://doi.org/10.22146/mot.109159

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