COMPARISON OF PHYSICAL STABILITY PROPERTIES OF POMEGRANATE SEED OIL NANOEMULSION DOSAGE FORMS WITH LONG-CHAIN TRIGLYCERIDE AND MEDIUM-CHAIN TRIGLYCERIDE AS THE OIL PHASE

https://doi.org/10.22146/tradmedj.12823

Sri Hartanti Yuliani(1*), Medaliana Hartini(2)

(1) Faculty of Pharmacy, Universitas Sanata Dharma
(2) Faculty of Pharmacy, Universitas Sanata Dharma
(*) Corresponding Author

Abstract


Pomegranate seed oil has antioxidant, anti-inflammatory, and chemo preventive activities. Pomegranate seed oil is lipophilic substance suitable to be prepared in emulsion dosage forms. Long-chain triglyceride (LCT) and medium-chain triglyceride (MCT) are commonly used as oil phase in emulsion dosage forms. This research aimed to compare the use of LCT and MCT in the Nano emulsion formula of pomegranate seed oil dosage forms. Formulation of pomegranate seed oil Nano emulsion was conducted using high energy emulsification. Parameters observed were pH, Nano emulsion type, percent transmittance, viscosity, turbidity, and droplet size before and after 3 cycles of freeze-thaw. The result showed that there was no significant difference between physical properties of pomegranate oil Nano emulsion with LCT as oil phase and pomegranate oil Nano emulsion with MCT as oil phase. Moreover, physical stability of pomegranate oil Nano emulsion with LCT as oil phase was better than pomegranate oil Nano emulsion with MCT as oil phase.

Keywords


Nano emulsion, pomegranate oil, MCT, LCT



References

Affandi, M.M.M., Julianto, T., and Majeed, A., 2011, Development and Stability Evaluation of Astaxanthin Nanoemulsion, Asian J Pharm Clin Res, 4 (1):142-148.

Aslam, M.N., Lansky, E.P., Varani, J., 2006. Pomegranate as a cosmeceutical source: Pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. J. Ethnopharmacol. 103: 311–318.

Bouchemal, K., Briançon, S., Perrier, E., Fessi, H., 2004. Nano-emulsion formulation using spontaneous emulsification: Solvent, oil and surfactant optimisation. Int. J. Pharm. 280: 241–251.

Chen, H., Khemtong, C., Yang, X., Chang, X., Gao, J., 2011. Nanonization strategies for poorly water-soluble drugs. Drug Discov. Today 16: 354–360.

Davidov-Pardo, G., McClements, D.J., 2015. Nutraceutical delivery systems: Resveratrol encapsulation in grape seed oil nanoemulsions formed by spontaneous emulsification. Food Chem. 167: 205–212.

Fletcher, P.D.I. and Suhling, K., 1998, Interaction Between Weakly Charged Oil in- Water Microemulsion Droplets, Langmuir, 14 (15): 4065-4069.

Gupta, P.K., Pandit, J.K., Kumar, A., Swaroop, P., and Gupta, S., 2010, Pharmaceutical Nanotechnology Novel Nanoemulsion-High Energy Emulsification Preparation, Evaluation and Application, T. Ph. Res., 3:117-138.

Huynh-Ba, K., 2009. Handbook of Stability Testing in Pharmaceutical Development. Springer New York. pp. 34

Ismail, T., Sestili, P., Akhtar, S., 2012. Pomegranate peel and fruit extracts: A review of potential anti-inflammatory and anti-infective effects. J. Ethnopharmacol. 143: 397–405.

Lansky, E.P., Newman, R.A., 2007. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J. Ethnopharmacol. 109: 177–206.

Mahdi, E.S., Noor, A.M., Sakeena, M.H., Abdullah, G.Z., Abdulkarim, M.F., Sattar, M.A., 2011. Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nanoemulsion delivery system for 30 % ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging. Int. J. Nanomedicine. 6: 2499–2512.

Melo, I.L.P., Carvalho, E.B.T. de;, Mancini-filho, J., 2014. Pomegranate Seed Oil (Punica granatum L .): A Source of Punicic Acid ( Conjugated α -Linolenic Acid ). J. Hum. Nutr. Food Sci. 2: 1–11.

Miguel, M.G., Neves, M. a, Antunes, M.D., 2010. Pomegranate (Punica granatum L.): A medicinal plant with myriad biological properties - A short review. J. Med. Plants Res. 4: 2836–2847.

Silva, A.P.C., Nunes, B.R., Oliveira, M.C., Koester, L.S., Mayogra, P., Bassani, V.L., et al., 2009, Development of Topical Nanoemulsions Containing the Isoflavone Genistein, Pharmazie, 64: 32-35.

Schubert, S.Y., Lansky, E.P., Neeman, I., 1999. Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. J. Ethnopharmacol. 66: 11–17.

Suciati, T., Aliyandi, A., Satrialdi, 2014. Development of transdermal nanoemulsion formulation for simultaneous delivery of protein vaccine and artin-m adjuvant. Int. J. Pharm. Pharm. Sci. 6: 536–546.

Tadros, T., Izquierdo, P., Esquena, J., Solans, C., 2004. Formation and stability of nano-emulsions. Adv. Colloid Interface Sci. 108-109: 303–318.

Verardo, V., Garcia-Salas, P., Baldi, E., Segura-Carretero, A., Fernandez-Gutierrez, A., Caboni, M.F., 2014. Pomegranate seeds as a source of nutraceutical oil naturally rich in bioactive lipids. Food Res. Int. 65: 445–452.

Wooster, T.J., Golding, M., Sanguansri, P., 2008. Impact of oil type on nanoemulsion formation and Ostwald ripening stability. Langmuir 24: 12758–12765.



DOI: https://doi.org/10.22146/tradmedj.12823

Article Metrics

Abstract views : 4360 | views : 15929

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2016 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada