Identification of ɤ-Aminobutyric Acid (GABA) in Loloh as A Potential Drink as Antihipertension
I Gusti Ayu Wita Kusumawati(1*), Ni Made Indri Sugiantari(2), I Gede Ariyasa(3), Ida Bagus Agung Yogeswara(4)
(1) Program of Nutrition Study, Faculty of Health, Science, and Technology, University of Dhyana Pura, Bali
(2) Program of Nutrition Study, Faculty of Health, Science, and Technology, University of Dhyana Pura, Bali
(3) Program of Nutrition Study, Faculty of Health, Science, and Technology, University of Dhyana Pura, Bali
(4) 1) Program of Nutrition Study, Faculty of Health, Science, and Technology, University of Dhyana Pura, Bali 2) Department of Food Science and Technology, University of Natural Resources and Applied Life Sciences Bodenkultur, Vienna
(*) Corresponding Author
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Abe, Y., Umemura, S., Sugimoto, K.,Hirawa, N., Kato, Y., Yokoyama. (1995). Effect of Green Tea Rich in Gamma Aminobutyric Acid on Blood Pressure of Dahl salt-sesnsitive rats. American Journal of Hipertension, 8,74-79.
Akama, K., Kanetou,J., Shimosaki,S., Kawakami,K., Tsuchikura,S., & Takaiwa, F. (2009). Seed spesific expression of truncate OsGAD2 produces GABA-enriched rice grains that influence a decrease in blood pressure in spontaneously hypertensive rats. Transgenic Research, 18, 865-876.
Akihiro,T., Koike,S., Tani, R., Tominaga,T., Watanabe,S., Iijima,Y., & Ezura,H. (2008). Biochemical mechanism on GABA accumulation during fruit development in tomato. Plant and cell Physiology, 49 (9), 1378-1389.
Algridas, J., Januskevicience,G., Andruleviciute,V. (2012). Chemical Compostion and Energetic Values of Selected Vegetables Spicies in Lithuanian Supermarkets. Veterinarija Ir Zootechnika (Vet Met Zoot) 58 (80).
Amin, Md Zainul, Shariar,K., Sawraz,a.M., Satter,A. (2015) A Comparative Nutritional Analysis of Red Amarant (Amaranthus Tricolor L) on Refrigerating and nNn-Refrigerating Condition. International Journal of Green and Herbal Chemistry. Vol 4, No 3 243-255.
Aoki, H., Furuya, Y., Endo, Y., & Fujimoto, K. (2003). Effect of gamma aminobutyric acid-enriched tempeh-like fermented soybean (GABA-Tempeh) on the blood pressure of spontaneously hypertensive rats. Bioscience Biotechnology and Biochemisty, 67, 1806-1808.
Ayu Kusuma Wardani, I Gusti Agung., Ketut Agus Arianta. (2015). Efektivitas Ekstrak Etanol Daun Bayam Merah (Amaranthus tricolor) sebagai Deuretik pada Tikus Putih Jantan Galur Wistar (Rattus Hovergicus).
Duyff, RL. (2012). American Dietetic Association. Complete food and nutrition guld. Houghton miffle harcourt
Endrizzi, I., Pirretti, G., Calo,DG., Gaspen, F. (2009). A consumer study of fresh juice containing berry fruits. J.Sci Food Agric. 89 (7):1227-1235.
Hamauzu, Y. and Zhang, D. (2004). Phenolics, ascorbic acid, carotenoids and antioxidant activity of broccoli and their changes during conventional and microwave cooking. Food Chemistry, 88: 503-509.
Hayakawa, K, Kimura M, Kamata K. (2002). Mechanism Underlying gamma aminno butyric-acid –induced antihypertensive effect in spontaneously hypertensive rats. Eur.J.Pharmac.438,107-113.
Hayakawa,K., Kimura, M., & Yamori, Y. (2005). Role of the renal nerves in gamma aminobutyric acid- induced antihypertensive effect in spontaneously hypertensive rats. European Journal of Pharmacology. 524.120-125
Hayakawa,K., Kimura, M., Kasaha, K., Matsumoto, K., Sansawa, H., & Yamori, Y. (2004). Effect of gamma aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hipertensive and normotensive wistar-Kyoto rats. British Journal of Nutrition,92, 411-417.
Indrowati,M., Pudji,A., Rarastoeti,P., Rumiyati. (2015). Deteksi Gamma-Aminobutyric Acid (GABA) Pada Daun Artocarpus Altilis. Seminar Nasional Pendidikan Sains FIKP UNS.
Joint National Commitee (JNC). (2003). Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. US Departemnet of Health dan Human Service.
Kimura, M., Hayakawa, K., &Sansawa, H. (2002). Involvement of gamma aminobutyric acid (GABA) B receptors in the hypotensive effect of systemically administered GABA in spontaneously hypertensive rats. The Japanese Journal of Pharmacology, 89,388-394.
Musa, A dan Ogbadoyi, E.O. (2012). Effect of Processing Methods on some Micronutrients, Antinutrients and Toxic Substance in Hibicus sabdariffa. Asian Journal of Biochemistry. 7 (2) : 63-79.
Nathalie, Lisbeth Leurs. 2009. Medical, Aromatic, and Cosmetic (MAC) Plants for Community Health and Bio-Cultural Diversity Conservation in Bali, Indonesia. L.N. Leurs page 124:127
Nielsen, S.S. (2010). Food analysis laboratoty manual. Department of Food Science. Purdue University West Lafayette. IN USA
Norikura, T., Kojima, Y.A., Shamizu,M., Huang. X.Xu, S., Kametami, S., Rho, SN., Kennedy, D.O., and Matsui, Y.I. (2008). Anticancer activities and mechanism of Blumea balsamifera exctract in hepatocellular carsinoma cells. Am J Chib Med. 36 (2):411-24
Qiu, T., Li,H., & Cao, Y. (2009). Pre-staining thin layer chromatography method for amino acid detection Afr J Biotechnol, 9, 8679-8681
Riset Kesehatan Dasar. (2013) Penyakit tidak menular. Halaman : 121-136
Sacks,F.M., Laura,F.S., Willia,M.V., lawrence,S.R., George,A.B., David,H., Eva,O., Paul,R.C., Edgar,R.M., Denise,G.S.M., Njeri,K., Pao-Hwa,L., Mikel,A., Marlene,M.M.W., Thomas,J.M., Michael,A.P., Jettrey,A.C. (2001). Effect of Blood Pressure of Reduce Dietary Sodium and The Dietary Approach to Stop Hypertension (DASH) Diet. The New England Journal of Medicine. 344 : 3-10.
Santos, P.C.J.L., Krieger, J.E., and Pireira, A.C. (2012). Renin agiotensin system hypertension and chronic disease. Pharmacogenetic implication Journal of Pharmacological science, 120:77-78.
sembung (Blumea balsamifera).
Winarno, F.G. (2008). Kimia Pangan dan Gizi. Bogor : Mrio Press.
Wita, I.G.A., Darmawijaya, I Putu., Yogeswara, I.B.A., Santoso, U., Marsono, Y. (2016). Formulasi dan kemampuan menangkal radikal bebas dari loloh
Wita, I.G.A., I.M Wisnu A.P., Yogeswara, I.B.A., Santoso, U., Marsono, Y. (2016). Antioxidannt and antihypertensive activity of loloh sembung (Blumea balsamifera). Traditional Medecine Journal. Vol 2. No 3.
Wita, I.G.A., Yogeswara, I.B. (2016). Antioxidant and Antibacterial Capacity of Loloh Sembung (Blumea balsamifera) based on Extraction Method. Trad.Med.J. Vol. 21 (3). Page 143-148.
Wita, I.G.A.,Darmawijaya, I Putu ., & Yogeswara, I.B.. 2014. Potensi aktioksidan loloh tempuyung (Sonchus arvensis L.) sebagai minuman fungsional. Prosiding Seminar Nasional Biologi FMIPA UNHI
Yamakoshi,J., Fukuda,S., Satoh, T., Tsuji R., Saito M. (2007). Antihypertensive and natriuretic effect of less sodium soy sauce containing gamma aminobutyric acid in spontaneously hipetensive rats. Bioscience Biotechnology and Biochemisty, 71, 165-173
Yang,N.C., Kun,Y.J., Chin,Y.T. (2012). Antihypertensive Effect of Mulberry Leaf Aqueous Extract Containing ɤ-Aminobutyric Acid in Spontaneously Hypertensive Rats. Food Chemistry 132.1796-1801
Yogeswara, I.B.A., Sumadewi, U., Rahayu, E., Indrati, R. 2017. Isolasi dan Skrining Bakteri Asam ` Laktat Isolat Asam ɤ-Aminobutirat. Abstrak.
Yoshimura,M., Toyoshi,T., Sano,A., Izumi,T., Fujii,T., Konishi,C. (2010). Antihypertensive effect of gamma amiobutyric acid rich tomato cultiver ‘DG03-9’ in
DOI: https://doi.org/10.22146/mot.28516
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