Wound Healing Activity of Ethanolic Extract Gel of Tawas Ut Tuber (Ampelocissus rubiginosa L.) in Incisional Model Wistar Rats
Khoerul Anwar(1*), Dewita Fitri Widodo(2), Nurlely Nurlely(3), Liling Triyasmono(4), Sudarsono Sudarsono(5), Agung Endro Nugroho(6)
(1) Study Program of Pharmacy, Lambung Mangkurat University
(2) Study Program of Pharmacy, Lambung Mangkurat University
(3) Study Program of Pharmacy, Lambung Mangkurat University
(4) Study Program of Pharmacy, Lambung Mangkurat University
(5) Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada
(6) Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author
Abstract
Keywords
Full Text:
PDFReferences
Allen, L.V., Jr & Ansel, H.C., 2014, Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems, Tenth Edition, Lippincott Williams & Wilkins, Philadelphia.
Ardiana, T., Kusuma, A.R.P. & Firdaus M.D., 2015, ‘Efektivitas Pemberian Gel Binahong (Anredera cordifolia) 5% terhadap Jumlah Sel Fibroblast pada Soket Pasca Pencabutan Gigi Marmut (Cavia cobaya)’, Odonto Dental Journal, 2, 64-70.
Arif, A., Chaidir, R., Ismono, D. & Hidajat, N.N., 2010, ‘Perbandingan Tensile Strength Pasca Repair menggunakan Teknik Modifikasi Kessler 2, 4 dan 6 Strand yang dinilai pada Minggu Ketiga Penyembuhan Ruptur Tendon Achilles Kelinci’, Majalah Orthopaedi Indonesia, 38, 8-16.
Arnida, Wahyono, Mustofa, & Asmahsusidarti, R., 2015, ‘In Vitro Antiplasmodial Activity of Ethanol Extracts of Borneo Medicinal Plants (Hydrolea spinosa, Ampelocissus rubiginosa, Uraria crinite, Angiopteri sevecta)’, International Journal of Pharmacy and Pharmaceutical Sciences, 7, 72-75.
Arum, Y.P., Supartono, & Sudarmin, 2012, ‘Isolasi dan Uji Daya Antimikroba Ekstrak Daun Kersen (Muntingia calabura)’, Jurnal MIPA UNNES, 35, 165-174.
Astuti, K.I., Anwar, K. & Biworo, A., 2016, ‘Uji Aktivitas Infusa Akar Tawas ut (Ampelocissus rubiginosa L.) sebagai Hepatoprotektor terhadap Mencit Putih Jantan Balb/C yang diinduksi Karbon Tetraklorida (CCl4)’, Jurnal Pharmascience, 3, 57 - 63.
Dewantari, D.R. & Sugihartini, N., 2015, ‘Formulasi dan Uji Aktivitas Gel Ekstrak Daun Petai Cina (Leucaena glauca, Benth) sebagai Sediaan Obat Luka Bakar’, Farmasains, 2, 217-222.
Farouk, L., A. Laroubi, R. Aboufatima, A. Benharref, & A. Chatt, 2008, ‘Evaluation of The Analgesic Effect of Alkaloid Extract of Peganum harmala L.: Possible Mechanisms Involved’, Journal of Ethnopharmacology, 115, 449-454.
Karodi, R., Jadhav, M., Rub, R. & Bafna, A., 2009, ‘Evaluation of The Wound Healing Activity of a Crude Extract of Rubia cordifolia L. (Indian madder) in Mice’, International Journal of Applied Research in Natural Products, 2, 12-18.
Kartikaningtyas, A.T., Prayitno, & Lastiannya, S.P., 2015, ‘Pengaruh Aplikasi Gel Ekstrak Kulit Citrus sinensis terhadap Epitelisasi pada Penyembuhan Luka Gingiva Tikus Sprague Dawley’, Majalah Kedokteran Gigi Indonesia, 1, 86-93.
Khaharap, E., 2012, ‘Uji Antibakteri Ekstrak Etanol Akar Tawas ut (Ampelocissus rubiginosa Lauterb.) pada Eschericia coli dan Staphylococcus aureus Secara In Vitro’, Skripsi, Program Studi Farmasi, Universitas Lambung Mangkurat.
Khan, M.M.A.A., Naqvi, T.S. & Naqvi, M.S., 2012, ‘Identification of Phytosaponins as Novel Biodynamic Agents: An Updated Overview’, Asian Journal Experimental Biological Sciences, 3, 459-467.
Kim, H.P., Son, K.H., Chang, H.W. & Kang, S.S., 2004, ‘Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms’, Journal of Pharmacological Sciences, 96, 229-245.
Kokane, D.D., More, R.Y., Kale, M.B., Nehete, M.N., Mehendale, P.C. & Gadgoli, C.H., 2009, ‘Evaluation of Wound Healing Activity of Root of Mimosa pudica’, Journal Ethnopharmacology, 124, 311-315.
Kumar, M.S., Kirubanandan, S., Sripriya, R. & Sehgal, P.K., 2008, ‘Triphala Promotes Healing of Infected Full-Thickness Dermal Wound’, Journal of Surgical Research, 144, 94-101.
Marliana, S.D., V. Suryanti, & Suyono, 2005, ‘Skrining Fitokimia dan Analisis Kromatografi Lapis Tipis Komponen Kimia Buah Labu Siam (Sechium edule Jacq. Swartz.) dalam Ekstrak Etanol’, Biofarmasi, 3, 26-31.
Mehta, B.K., Pattnaik, A. & Kumar, A., 2014, ‘Enchancement and Validation of Wound Healing Activity with Herbal Gel Formulated from Sub-Fraction of Buchnania lanzan Spreng. Bark Extract’, International Journal of Pharmacy and Pharmaceutical Sciences, 6, 281-286.
Mehta, D.P., Rathod, H.J., Shah, D.P. & Shah, C.N., 2015, ‘Review on Microemulsion Based Gel: A Recent Approach for Topical Drug Delivery System’, Research J. Pharm. And Tech. 8, 118-126.
Meskin, M.S., W.R. Bidlack, A.J. Davies, D.S. Lewis, & R.K. Randolph, 2004, Phytochemicals Mechanisms of Action, CRC Press, Boca Raton.
Miladiyah, I. & Prabowo, B.R., 2012, ‘Ethanolic Extract of Anredera cardifolia (Ten.) Steens Leaves Improved Wound Healing in Guinea Pigs’, Universa Medicina, 31, 4-11.
Morison, M.J., 2004, Manajemen Luka, Penerbit Buku Kedokteran EGC, Jakarta.
Napanggala, A., Susanti, & Apriliana, E., 2014, ‘Effect of Jatropha’s (Jatropha carcas L.) Seed Topically to The Level of Cuts Recovery on White Rats Sprague dawley Strain’, J. Majority, 3, 26-35.
Nasrabadi, M.H., Ebrahimi, M.T., Banadaki, S.D., Kajousangi, M.T. & Zahedi, F., 2011, ‘Study of Cutaneous Wound Healing in Rats Treated with Lactobacillus plantarum on Days 1, 3, 7, 14, and 21’, African Journal of Pharmacy and Pharmacology, 5, 2395-2401.
Nayak, B.S., S. Sandiford, & A. Maxwell, 2009, ‘Evaluation of The Wound-healing Activity of Ethanolic Extract of Morinda citrifolia L. Leaf’, Evidence-based Complement Alternative Medicine, 6, 351-356.
Nisbullah, R.V., 2013, ‘Formulasi dan Evaluasi Sediaan Salep Ekstrak Etanol Akar Tawas ut (Ampelocissus rubiginosa Lauterb.) dengan Variasi Konsentrasi Vaselin Album dan Cera Alba’, Skripsi, Program Studi Farmasi, Universitas Lambung Mangkurat.
Nurhalimah, H., Wijayanti, N. & Widyaningsih, T.D., 2015, ‘Efek Antidiare Ektrak Daun Beluntas (Pluchea indica L.) terhadap Mencit Jantan yang diinduksi Bakteri Salmonella thypimurium’, Jurnal Pangan dan Agroindustri, 3, 1083-1094.
Panda, V., Sonkamble, M. & Patil, S., 2011, ‘Wound Healing Activity of Ipomea batatas Tubers (Sweet Potato)’, Functional Foods in Health and Disease, 10, 403-415.
Prasetyo, B.P., Wientarsih, I. & Priosoeryanto, B.P., 2010, ‘Aktivitas Sediaan Gel Ekstrak Batang Pohon Pisang Ambon dalam Proses Penyembuhan Luka pada Mencit’, Jurnal Veteriner, 11, 70-73.
Reddy, B.S., Reddy, R.K.K., Naidu, V.G.M., Madhusudhana, K., Agwane, S.B., Ramakrishna, S. & Diwan, P.V., 2008, ‘Evaluation of Antimicrobial, Antioxidant and Wound-Healing Potentials of Holoptelea integrifolia’, Journal of Ethnopharmacology, 115, 249-256.
Robinson, T., 1995, Kandungan Organik Tumbuhan Tinggi, diterjemahkan Padnawinata K, Edisi ke-6, Institut Teknologi Bandung, Bandung.
Sabirin, I.P.R., Maskoen, A.M. & Hernowo, B.S., 2013, ‘Peran Ekstrak Etanol Topikal Daun Mengkudu (Morinda citrifolia L.) pada Penyembuhan Luka ditinjau dari Imunoekspresi CD34 dan Kolagen pada Tikus Galur Wistar’, Majalah Kedokteran Bandung, 45, 226-233.
Sgonc, R. & Gruber, J., 2013, ‘Age-Related Aspects of Cutaneous Wound Healing: A Mini-Review’, Gerontology, 59, 159-164.
Shang, J.H., Cai, X.H., Feng, T., Zhao, Y.L., Wang, J.K., Zhang, L.Y., Yan, M. & Luo, X.D., 2010, ‘Pharmacological Evaluation of Alstonia scholaris: Anti-inflammatory and Analgesic Effects’, Journal Ethnopharmacology, 129, 174-181.
Shukla, A., Rasik, A.M., Jain, G.K., Shankar, R., Kulshrestha, D.K. & Dhawan, B.N., 1999, ‘In Vitro and In Vivo Wound Healing Activity of Asiaticoside Isolated from Centella asiatica’, Journal of Ethnopharmacology, 65, 1-11.
Solihah, M.A., W.I.W. Rosli, & A.R. Nurhanan, 2012, ‘Phytochemicals Screening and Total Phenolic Content of Malaysian Zea mays Hair Extracts’, International Food Research Journal, 19, 1533-1538.
Tranggono, R.I. & Latifah, F., 2007, Buku Pegangan Ilmu Pengetahuan Kosmetik, Penerbit Gramedia Pustaka Utama, Jakarta.
Wijaya, J.I., 2013, ‘Formulasi Sediaan Gel Hand Sanitizer dengan Bahan Aktif Triklosan 1,5% dan 2%’, Calyptra, 2, 1-14.
Zahra, A.A., Kadir, F.A., Mahmood, A.A., Al Hadi, A.A., Suzy, S.M., Sabri, S.Z., Latif, I.I. & Ketuly, K.A., 2011, ‘Acute Toxicity Study and Wound Healing Potential of Gynura procumbens Leaf Extract in Rats’, Journal of Medicinal Plants Research, 5, 2551-2558.
DOI: https://doi.org/10.22146/mot.29063
Article Metrics
Abstract views : 4619 | views : 7686Refbacks
- There are currently no refbacks.
Copyright (c) 2018 Majalah Obat Tradisional
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Faculty of Pharmacy
Universitas Gadjah Mada