Antiinflammatory Activity Test of Aqueous Extracts Herb of Ciplukan (Physalis angulata L.) in Caragenan Inducted Wistar Rat (Rattus norvegicus L.)

https://doi.org/10.22146/mot.31556

Sri Luliana(1), Ressi Susanti(2), Ellya Agustina(3*)

(1) Study Program of Pharmacy, Faculty of Medicine, Tanjungpura University, Pontianak
(2) Study Program of Pharmacy, Faculty of Medicine, Tanjungpura University, Pontianak
(3) Study Program of Pharmacy, Faculty of Medicine, Tanjungpura University, Pontianak
(*) Corresponding Author

Abstract


Ciplukan (Physalis angulata L.) empirically has been used to treat sore throat, inflammatory of the airways, gingivitis, and other diseases. This research was to determine the inflammatory activity of water herb extract of P. angulata L. on white male rats edema Wistar strain induced carragenan. P. angulata L. herbs were extracted using infundation method and were dried with frezee drying. Parameter that would be observed of this research was the inhibition foot edema of rat after induction of 0.1 mL of λ-carragenan 2% for 360 minutes. Measurement of edema volume was using pletismometer. The results of this research showed water herb extract of P. angulata L. in dose 100, 200, and 400 mg/kgBW has potensial as an antiinflammatory drug by percent respectively were 20.13; 28.93; and 34.70%. The three doses hasn’t showed any significant difference (p>0.05) with the positive control of diclofenac sodium dose 4.5 mg/kgBW was 33.90%. Conclusion of this research states water herb extract of P. angulata L. has antiinflammatory activity with effective dose of 400 mg/kgBW.

Keywords


Ekstrak air herba P. angulata L.; Pletismometer; λ-karagenan; Antiinflamasi; Water herb extract of P. angulata L.; Pletismomoter; λ-carragenan; Antiinflammatory

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References

Adcock, P.B.& I., 1993. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacology Science, 14(12), pp.436–441.

Agra, M.F. et al., 2007. Medicinal and poisonous diversity of the flora of “Cariri Paraibano”, Brazil. Journal of Ethnopharmacology, 111(2), pp.383–395.

Bastos, G.N.T. et al., 2008. Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways. Journal of Ethnopharmacology, 118, pp.246–251.

Choi, E. & Hwang, J., 2003. Investigations of anti-inflammatory and antinociceptive activities of Piper cubeba , Physalis angulata and Rosa hybrida. Journal of Ethnopharmacology, 89, pp.171–175.

Dalimartha, S., 2006, Atlas Tumbuhan Obat Indonesia, Jilid 4, Jakarta, Puspa Swara, 21

Depkes RI., 1995, Farmakope Indonesia, Edisi Keempat., Jakarta, Depkes RI, pp.9.

Depkes RI., 2000, Parameter Standar Umum Ekstrak Tumbuhan Obat, Jakarta, Depkes RI, pp.7-11.

Hanani, E., 2015, Analisis Fitokimia, Jakarta, EGC.

Harborne, J.B., 1987. Metode Fitokimia: penuntun cara modern menganalisis tumbuhan, Penerjemah: Kosasih Padmawinata dan Iwang Soediro, Bandung: ITB Press.

Kristanti, A.N., Aminah, N.S., Tanjung, M., dan Kurniadi, B., 2008, Buku Ajar Fitokimia, Surabaya, Airlangga University Press

Lee, Y.Y. et al., 2015. Anti-inflammatory Mechanism of Ginseng Saponin Metabolite Rh3 in Lipopolysaccharide-Stimulated Microglia: Critical Role of 5???-Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway. Journal of Agricultural and Food Chemistry, 63(13), pp.3472–3480.

Mahalakshmi AM, R.B.N., 2014. Physalis angulata L.: an Ethnopharmacological Review. Indo American Journal of Pharmaceutical Research, 4(03), pp.1479–1486.

Price, A.J., Monks, C.D. & Kelton, J.A., 2013. Cutleaf Groundcherry ( Physalis angulata ) Density , Biomass and Seed Production in Peanut ( Arachis hypogaea L .) Following Regrowth Due to Inadequate Control. International Journal of Pharma and Bio Sciences, 4(3), pp.120–126.

Public Health Guidance Note, 2002. Organic Solvents. Public Health Guidance Note, pp.1–4.

Rengifo S., E.& G.V.., 2013. Physalis angulata L. (Bolsa Mullaca): A Review of its Traditional Uses, Chemistry and Pharmacology. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 12(5), pp.431 – 445.

Di Rosa, M., Giroud, J.P. & Willoughby, D. a., 1971. Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. The Journal of Pathology, 104(1), pp.15–29.

Simon Gibbons and Alexander I. G., 1998. Isolation br planar Chromatography, Natural Products Isolation, Humana Press, Totowa: New Jersey, pp.209-245

Soares, M.B.P., Bellintani, M.C., Ribeiro, I.V., Tomassini, T.C.B., Santos, R.R., 2003. Inhibition of macrophage activation and lipopolysaccharide-induced death by seco-steroids purified fromPhysalis angulata L. European Journal of Pharmacology, 459(107-112).

Supachok, P. & Vajrodaya, S., Comparative Phytochemistry of Physalis angulata L. (Family Solanaceae). Short Comunication. Departemetn of Botani, Faculty of Science, Kasetsart University Bangkok

T.N.L.,, Huong et al., 2016. Chemical constituents of Physalis angulata L. (family solanaceae). Can Tho University Journal of Science, 02, p.46.

Ukwubile, C.A. & Oise, I.E., 2016. Analgesic and Anti-inflammatory Activity of Physalis angulata Linn. (Solanaceae) Leaf Methanolic Extract in Swiss Albino Mice. International Biology Biomedicine Journal, 2(4), pp.2–5.

Vieira, A.T. et al., 2005. Mechanisms of the anti-inflammatory effects of the natural secosteroids physalins in a model of intestinal ischaemia and reperfusion injury. British journal of pharmacology, 146(2), pp.244–51.



DOI: https://doi.org/10.22146/mot.31556

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