Wound Healing Effects of Edible Bird’s Nests Oinment (Aerodramus fuciphagus) in Alloxan-Induced Male Rats

https://doi.org/10.22146/mot.39072

Dita Ayulia Dwi Sandi(1*), Yaumi Musfirah(2)

(1) Sekolah Tinggi Ilmu Kesehatan Borneo Lestari, Banjarbaru
(2) Sekolah Tinggi Ilmu kesehatan Borneo Lestari, Banjarbaru
(*) Corresponding Author

Abstract


Edible bird's nest (Aedrodramus fuchipagus) contains EGF (Epidermal Growth Factor) and sialic acid which is useful in wound healing. The aim of this study was to investigate the effect of edible bird's nest on the injured Alloxan-induced rats to form optimal ointment formulation of edible bird's nest (Aedrodramus fuchipagus) which can heal wounds. The method used in this research is experimental using 25 Sprague Dawley rats divided into 5 groups in which each group consists of 5 rats; Group I was the control group (Vaseline + Betadine®), Group II, III, and IV were the group of EBN + Betadine® with concentrations of 10%, 20%, and 30%; and Group V was of the Sanoskin Meladerm® (SM) + Betadine® group. The rats were modeled for diabetes by inducing Alloxan (150mg/kgBW/i.p) and exposed with DM when the blood sugar level was > 200 mg/dL. The back skins were sliced as long as 2 cm and 2 mm depth and were given treatment according to the group, 1 x daily for 10 days. Parameters that were noticed were length wound, length of the dry wound, and the number of days of scab formation. The results obtained in the control group were 10%, 20%, and 30% on the EBN group, and the SM group on the 9th day were 1.3±0.2449, 0.34±0.427, 0.56±0.4586, 0±0, 0±0. The results of the average length of the dry wound in the control group were 10%, 20%, and 30% on the EBN group, and the SM group were 1±0.5, 2±1.5, 4±0, 8, 1±0.8, and 2±0.63. While the result of the average day of scab formation on the control group was 10%, 20%, and 30% on the EBN groups, SM Groups were 1.3±0.47, 2.2±1.6, 3.8±0.8, 1±0, and 2±0.63. Based on Kruskal Wallis test, there were significant differences in the wound length among treatment groups (sig 0.013) and significant differences in dry wounds among treatment groups (sig 0.046), but there was no difference in the time of scab formation among treatment groups (sig 0.066). In conclusion, edible bird’s nest (Aedrodramus fuchipagus) ointment concentration of 30% is the most optimal ointment to wound healing in Alloxan-induced male rats when compared to Sanoskin Melladerm.

Keywords


Edible Bird’s Nest; Aerodramus fuciphagus; Wound healing; diabetes mellitus; rats

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References

American Diabetes Association. 2003. Peripheral arterial diseasein people with diabetes. Diabetes care. 26 (12) : 3333-3341.

American Diabetes Association. 2017. Standars of medical care in diabetic - 2017. The journal of clinical and applied research and education. 40 (1).

Butler, L.K. 1995. Regulation of Blood Glucose Levels in Normal and Diabetic Rats. Texas: Divisiun of Biological Sciences. 181-202.

Colombo JP, Garcia-Rodenas C, Guesry PR & Rey J. 2003. Potential effects of supplementation with amino acids, choline or sialic acid on cognitive development in young infants. Acta Paediatr Suppl. 92: 42-46.

Depkes RI. 2005. Pharmaceutical Care untuk penyakit Diabetes Mellitus. Departemen Kesehatan Republik Indonesia. Jakarta.

Dinar, D.D., Nashrullah & Prasetyo, T.A. 2005. Prototipe Alat pengering (Non Vacum) pada Industri pencucian Sarang Walet. Jurnal Teknik Mesin (ISSN 1829-8958). Vol. 2 No. 2.

Fitriani, N. 2016. Uji Aktivitas Gel Etil P-Metoksinamat terhadap Penyembuhan Luka Terbuka pada Tikus Putih (Rattus novegicus) Jantan. Skripsi. UIN Syarif Hidayatullah, Jakarta.

Hamzah, Z., Ibrahim, N.H., Sarijini, Hussin, K., Hashim, O. & Lee, B.B. 2013. Nutritional Properties of Edible Bird Nest. Journal of Asian Scientific Research. 3(6): 600-607.

Hussain, H.E.M. 2002. Reverse of Diabetic Retinopathy in Streptozotocin Induced Diabetic Rats Using Traditional Indian Anti Diabetic Plan Azadirachta indika (L). Indian J. Clin. Biochem. 17:115-1.

Irma. 2014. Pemberian krim ekstrak sarang burung walet 10% meningkatkan epitelisasi pada penyembuhan luka kulit mencit (Mus musculus). Tesis. Universitas Udayana Denpasar.

Kantor Dagang dan Ekonomi Indonesia di Taiwan. 2012. Market brief Peluang ekspor sarang burung walet di pasar Taiwan. KDEI di Taiwan. Taiwan.

Keputusan Kepala Badan Karantina Pertanian. 2010. Keputusan Kepala Badan karantina Pertanian Nomor: 374/Kpts/KH.210/L/5/ 2010 tentang Petunjuk Teknis Penanganan dan Pemeriksaan Sarang Burung Walet dan Sriti, Badang Karantina Pertanian. Jakarta.

Konsul Perdangan. 2016. Laporan Market Brief : edisi Januari 2016 Sarang Burung Walet di Pasar Hongkong. Konsulat Jenderan Republik Indonesia Hongkong SAR. Republik Rakyat Tiongkok.

Nakagawa, H., Hama, Y., Sumi, T., Li, S., Maskos, K., Kalayanamitra, K., Mizumoto, S., Sugahara, K. & Teh, L. 2007. Occurrence of a nonsulfated chondroitin proteoglycan in the dried saliva of Collocalia swiftlets (edible bird’s-nest). Glycobiology. 17 (2) : 157–164.

Norhayati, M.K., Azman & Nazaimoon, W. 2010. Preliminary Study of the Nutritional Content of Malaysian Edible Bird’s Nest. Mal J Nutr. 16 (3) : 389-396.

Padmadisastra, Y., Syaugi, A., & Anggia, S. 2007. Formulasi Sediaan Salep Antikeloidal yang Mengandung Ekstrak Terfasilitasi Panas Microwave dari Herba Pegagan (Centella Asiatica (L.) Urban. Seminar Kebudayaan Indonesia Malaysia Kualalumpur. 28–31 Mei 2007.

Peter, C.Y.G. 2014. Authentication of Edible Bird’s Nest using advanced Analytical Techniques and Multivariated Data Analysis. Thesis. National University of Singapore.

Rolf, K.J. & Grobbelaar, A.O. 2012. A Review of fetal scarless healing. ISRN Dermatology. 2012 : 1-9.

Sandi, D.A.D. & Musfirah, Y. 2018. Pengaruh Basis Salep Hidrokarbon dan Basis Salep Serap terhadap Formulasi Salep Sarang Burung Walet Putih (Aerodramus fuciphagus). Jurnal Ilmiah Manuntung 4 (2) : 149-155.

Tim Penulis PS. 2009. Panduan Lengkap Walet. Penebar Swadaya. Jakarta.

Tung, C.H., Pan, J.Q., Chang, H.M. & Chou, S.H. 2008. Authentic determintion of Bird’s nests by saccharides profile. Journal of Food and Drug Analysis. 16 (4) : 86-91.



DOI: https://doi.org/10.22146/mot.39072

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