Accelerated Stability Test of Snakehead Fish Extract (Channa striata) and Kelulut Honey (heterotrigona itama) Ointment Combination with Tween 80 and Span 80 as an Emulsifying Agent

https://doi.org/10.22146/mot.66608

Wintari Taurina(1*), Mohamad Andrie(2), Taufik Nanda Pratama(3)

(1) Department of Pharmacy, Tanjungpura University, Pontianak
(2) Department of Pharmacy, Tanjungpura University, Pontianak
(3) Department of Pharmacy, Tanjungpura University, Pontianak
(*) Corresponding Author

Abstract


The combination of Snakehead Fish and Kelulut Honey has activity in accelerating the wound healing process. The ointment with active ingredients of Snakehead Fish extract and Kelulut Honey showed separation from the active ingredient and its base. The addition of tween 80 and span 80 is expected to increase the stability of the ointment preparation by keeping the water-phase droplets distributed uniformly on the ointment base. This study aimed to determine the effect of adding Tween 80 and Span 80 on the stability of the ointment preparation. The ointment was made by varying Tween 80 and span 80 by 2,5%: 5%: 7,5% and control (active ingredients without the addition of tween 80 and Span 80) as a comparison. The preparation was subjected to an accelerated stability test using a temperature of 40 ° ± 2 ° C / Relative humidity 75% ± 5% for 28 days by observing the organoleptic test, adhesion, spreadability, homogeneity test, pH test, and protection power. The data obtained were analyzed statistically using One Way Anova. The analysis showed that the addition of tween 80 and span 80 with a total concentration of 5% and 7,5% had a significant effect in increasing the spreadability, decreasing adhesion, and reducing the pH of the preparation. Formulas that meet the requirements in this study are F2 and F3, which have an average spreadability of 5,11 cm and 5,25 cm, adhesion of 96 seconds and 51 seconds, and pH of 6,02 and 5,02.


Keywords


Ointment; snakehead fish; kelulut honey; tween 80; span 80

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References

Alviodinasyari, R., Pribadi, E. S., & Soejoedono, R. D. (2019). Kadar Protein Terlarut dalam Albumin Ikan Gabus (Channa striata dan Channa micropeltes) Asal Bogor. Jurnal Veteriner, 20(3), 436. https://doi.org/10.19087/jveteriner.2019.20.3.436

Ayu, I. G., Krsna, S., Mulyani, S., & Suhendra, L. (2019). Pengaruh Nilai Hydrophile-Liphophile Balance (HLB) dan Jenis Ekstrak terhadap Karakteristik Krim Kunyit-Lidah Buaya (Curcuma domestica Val.- Aloe vera) The. Jurnal Ilmiah Teknologi Pertanian, 4(1), 54–61.

Dewi, M. A., Kartasasmita, R. E., & Wibowo, M. S. (2017). Uji Aktivitas Antibakteri Beberapa Madu Asli Lebah Asal Indonesia Terhadap Staphylococcus Aureus Dan Escherichia Coli. Kartika Jurnal Ilmiah Farmasi, 5(1), 27–30. https://doi.org/10.26874/kjif.v5i1.86

Forestryana, D., Surur Fahmi, M., & Novyra Putri, A. (2020). Pengaruh Jenis dan Konsentrasi Gelling Agent pada Karakteristik Formula Gel Antiseptik Ekstrak Etanol 70% Kulit Buah Pisang Ambon. Lumbung Farmasi: Jurnal Ilmu Kefarmasian, 1(2), 45. https://doi.org/10.31764/lf.v1i2.2303

Hasrawati, A., Famir, Y., & Mursyid, A. M. (2019). Formulasi dan Evaluasi Salep Ekstrak Daun Gulma Siam (Chromolaena odorata L.) Dengan Variasi Basis Salep. As-Syifaa Jurnal Farmasi, 11(01), 55–60.

Karnia, I., Hamidah, S., & Rahmat, A. (2019). Pengaruh Masa Simpan Madu Kelulut (Trigona sp.) Terhadap Kadar Gula Pereduksi dan Keasaman. Jurnal Sylva Scienteae, 02(6), 1094–1099.

Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (2009). Handbook of Pharmaceutical Excipients. Pharmaceutical Press and American Pharmacists Association.

Sandi, D. A. D., & Musfirah, Y. (2018). Pengaruh Basis Salep Hidrokarbon dan Basis Salep Serap terhadap Formulasi Salep Sarang Burung Walet Putih. Jurnal Ilmiah Manuntung, 2(2), 149–155.

Sari, D. K., Sugihartini, N., & Yuwono, T. (2015). Evaluasi Uji Iritasi Dan Uji Sifat Fisik Sediaan Emulgel Minyak Atsiri Bunga Cengkeh (Syzigium Aromaticum). Pharmaciana, 5(2), 115–120. https://doi.org/10.12928/pharmaciana.v5i2.2493

Susilowati, E. P., & Wahyuningsih, S. S. (2014). Optimasi Sediaan Salep yang Mengandung Eugenol dari Isolasi Minyak Cengkeh (Eugenia caryophylatta Thunb.). Indonesian Journal On Medical Science, 1(2), 29–34.

Tsabitah, A. F., Zulkarnain, A. K., Wahyuningsih, M. S. H., & Nugrahaningsih, D. A. A. (2020). Optimasi Carbomer, Propilen Glikol, dan Trietanolamin Dalam Formulasi Sediaan Gel Ekstrak Etanol Daun Kembang Bulan (Tithonia diversifolia). Jurnal Farmaseutik, 16(2), 111–118. https://doi.org/10.22146/farmaseutik.v16i2.45666

Wijonarko, B. (2016). Efektivitas topikal salep ekstrak binahong (Anredera cordifolia (Tenore) Steenis) terhadap proses penyembuhan luka ulkus diabetik pada tikus wistar (Rattus novergicus). Jurnal Ilmiah Kesehatan, 4(2), 1–11.

Wulandari, R. L., Zulfa, E., & Astuti, D. A. (2019). Formulasi dan Efek Salep Ekstrak Etanol Daun Jambu Biji (Psidium Guajava, L.) Dengan Basis Hidrokarbon terhadap Luka Sayat Pada Tikus Jantan Galur Wistar. Jurnal Ilmu Farmasi Dan Farmasi Klinik, 16(2), 139–148.

Zulfa, E., & Prasetyo, T. (2015). Formulasi Salep Ekstrak Etanolik Daun Binahong (Anredera cordifolia (Ten.) Steenis) dengan Berbagai Basis dan Uji Aktivitas. Jurnal Farmasi, 1(1), 41–48.



DOI: https://doi.org/10.22146/mot.66608

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