OPTIMIZATION FORMULA DISPERSIBLE TABLETS OF GUAJAVA LEAF EXTRACT (Psidium guajava L.) WITH COMBINATION DISINTEGRANTS OF CROSCARMELLOSE SODIUM AND SODIUM STARCH GLYCOLATE

https://doi.org/10.22146/tradmedj.7750

Aditya Novera Rachmawati(1), Wahyono Wahyono(2), T. Nanda Saifullah Sulaiman(3*)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


The efficacy and safety of guajava leaf (Psidium guajava L.) extract as antidiarrheal has been tested through pra-clinical and clinical studies. Now dosage form of guajava leaves extract as antidiarrheal has limitation for childrens because it is difficult oto be swallowed, it has high disintegration time and unpleasent smell and flavor so it needs an acceptable dosage formulation for childrens. The aim of this research is to optimize formula dispersible tablets with combination disintegrants of croscarmellose sodium (CCS) and sodium starch glycolate (SSG). Dispersible tablets were produced by dry granulation with five formulas, i.e. formula I (100% CCS), II(75%:25%), III(50%:50%), IV (25%:75%) and V (100% SSG). Standarization of the extract used organoleptic parameters, loss on drying value and thin layer chromatography (TLC). The dispersible tablets were tested for weight uniformity, friability, hardness, disintegration time, dispersion time, wetting time and TLC. Data were analyzed using sofware Design Expert® versi 7.1.4.0 to determine the optimum formula. The result showed that the different compositions of CCS-SSG influence the physical charasteristics of dispersible tablets. The higher of SSG content will increase the hardness, the disintegration time, the dispersion time and the wetting time. The optimum formula was the formula with combination of 71% CCS and 29% SSG.


Keywords


Dispersible tablets, CCS-SSG, Psidium guajava, simplex lattice design



References

Adisasmito, W., 2007, Faktor Resiko Diare pada Bayi dan Balita di Indonesia: Systematic Review Penelitian Akademik Bidang Kesehatan Masyarakat, Makara Kesehatan, 11(1): 1-10

Banker, G.S. and Anderson, N.R., 1986, Tablet, in Lachman, L., Lieberman, H.A. and Kanig, J.L., The Theory and Practice of Industrial Pharmacy, 3rd Edition, 683-703, Lea and Febiger, Philadelphia

Bhatt, Y., Deshmukh, A., Joshi, M., Nalle, S. and Paladi, R., 2009, Evaluation and Characterization of Dispersible Etoricoxib Tablets, Int. J. Pharm. Pharmaceutical Science Research, 1(2): 310-314

Birdi, T., Daswani, P., Brijesh, S., Tetali, P., Natu, A. and Antia, N., 2010, Newer Insight Into the Mechanisme of Action of Psidium guajava L. in Infectious Diarrhoea, BioMed Central (BMC) Complement Alternative Medicine, 10: 33

Bolton, S., 1997, Pharmaceutical Statistics: Practical and Clinical Applications, 3rd Edition, 610-611, Marcel Dekker Incorporation, New York

Cepuch, C., Ojoo, A., Amugene, B., Kusemererwa, D., Goffin, E., Saunders, P. and Atieno, R., 2010, Dispersible Tablets: A Novel Dosage Form for Children, Practical Pharmacy in Developing Country, 24: 3-6

Depkes., 1995, Farmakope Indonesia, Edisi IV, 7, 300, 404, 488-489, 515-616, 519, Depkes RI, Jakarta

EDQM, 2005, European Pharmacopeia 5.0, 628, European Directorate for the Quality of Medicines (EDQM)

Nagar, M. and Yadav, A.V., 2009, Cinnarizine Orodispersible Tablets: A Chitosan Based Fast Mouth Dissolving Technology, Int. J. Pharm. Tech. Res., 1(4): 1079-1091

Parrot, E.L., 1971, Pharmaceutical Technology: Fundamental Pharmaceutics, 3rd Edition, 73-89, 158-171, 389-390, Burgess Publishing Company, Minneapolis

Patel, R.P., Dhruv, J.H., Bhatt, B.J. and Suthar, A.M., 2010, Formulation, Development and Optimization of Cefditoren Pivoxil Dispersible Tablet, Int. J. Curr. Pharm. Res., 2(1): 20-25

Patil, S.B., Shahi, S.R., Udavant, Y.K., Atram, S.C., Salunke, R.J. and Neb, G.B., 2009, Formulation and Evaluation of Quick Dispersible Tablet of Olanzapine, International Journal of Pharmaceutical Research and Development, 7: 1-14

Rowe, R.C., Paul, J.S. and Owen, S.C., 2005, Handbook of Pharmaceutical Excipients, 5th Edition, 188-190, 211-212, 430-431, 442-444, 449-452, 701-703, Pharmaceutical Press, London

Sa’adah, A. and Fudholi, A., 2011, Optimasi Formula Tablet Teofilin Menggunakan Co-processed Excipients Campuran Laktosa dan Avicel, dalam Prosiding Seminar Nasional “Eight Star Performance Pharmacist”, 2010, 140, Program Pasca Sarjana Ilmu Farmasi Fakultas Farmasi UGM, Yogyakarta

Shahi, S.R., Agrawal, G.R., Shinde, N.V., Shaikh, S.A., Shaikh, S.S., Somani, V.G., Shamkuvar, P.B. and Kale, M.A., 2008, Formulation and In-Vitro Evaluation of Orodispersible of Etoricoxib Emphasis on Comparative Functionality Evaluation of Three Classes of Superdisintegrant, Rasayan Journal Chemical, 1(2): 292-300

Siregar, C.J.P. and Saleh, W., 2008, Teknologi Farmasi : Sediaan Tablet Dasar-Dasar Praktis, 145-146, 160, 169-170, Penerbit Buku Kedokteran EGC, Jakarta

Soares, L.A.L., George, G.O., Pedro, R.P. and Peter, C.S., 2005, Dry Granulation and Compression of Spray Dried Plant Extract, American Association Pharmaceutical Scientist Pharmaceutical Science Technology, 6(3): 359-366

Wagh, M.P., Yewale, C.P., Yate, S.U., Kothawade, P.I. and Mahale, G.H., 2010, Formulation and Evaluation of Fast Dispersible Tablet of Aceclofenac Using Different Superdisintegrant, Journal of Pharmacy and Pharmaceutical Science, 2: 154

WHO, 2005, WHO Monographs on Selected Medicinal Plants, Volume 4, 129-130, WHO

Winarno, M.W., 1998, Jambu Biji Menyetop Diare, Puslitbang Farmasi, Balitbang Kesehatan, Departemen Kesehatan RI

Young, P.M., Edge, S., Staniforth, J.N., Steele, D.F., Traini, D. and Price, R., 2007, Effect of Moisture on the Compressibility and Compactibility of Sodium Starch Glycolate, Pharmaceutical Development Technology, 12(2): 217-22



DOI: https://doi.org/10.22146/tradmedj.7750

Article Metrics

Abstract views : 2910 | views : 13987

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2015 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada