EFFECT OF TRAGACANTH AS BINDING AGENTS TO GINGER (Zingiber officinale Roxb.) LOZENGES

https://doi.org/10.22146/tradmedj.7982

Wintari Taurina(1*), Yandi Syukri(2), Asih Triastuti(3)

(1) Department of Pharmacy, Faculty of Medicine, Universitas Tanjungpura, Pontianak
(2) Department of Pharmacy, Faculty of Mathemathics and Natural Sciences, Universitas Islam Indonesia
(3) Department of Pharmacy, Faculty of Mathemathics and Natural Sciences, Universitas Islam Indonesia
(*) Corresponding Author

Abstract


Ginger (Zingiber Officinale Roxb.) is a traditional plants usually used to relieve pain, rheumatism, and neutralize poison. The aim of this study was to get the optimum concentration of tragacanth as a binding agent in ginger lozenges formulation. The components from ginger were extracted using percolation with ethanol 70% and then evaporated using rotary evaporator. Lozenges were made in three formulas ; formula 1 (5%), 2 (7,5%), 3 (10%) of tragacanth using wet granulation method. Granules and tablets were tested for its physical properties, and analyzed using Pearson correlation. The result showed that, all of three formulas were good, comply with a regulation of physical properties and soluble time in the mouth. Variation of tragacanth concentration affected physical properties of tablets. It showed that the greater concentration of tragacanth, the larger the hardness and the longer the soluble time of tablets. The formula (tragacanth 10% b/v) gave an optimum physical properties and soluble time of tablets, with weight variety deviation 0,98%, hardness 10,18 kg, friability 0.11% and soluble time 11.50 minutes. The three formulas were received by respondens with prerequirement of improving sweetness, repairing form and the color of tablets.


Keywords


Ginger lozenges, tragacanth, wet granulation method



References

Anonim, 1979, Farmakope Indonesia, edisi III, Departemen Kesehatan Republik Indonesia : Jakarta

Anonim, 1995, Farmakope Indonesia, edisi IV, Departemen Kesehatan Republik Indonesia : Jakarta

Fassihi, A.R. and Kanfer, E., 1986, Effect of Compressibility and Powder Flow Properties on Tablet Weight Variation, Drug Development and Industrial Pharmacy

Lachman, L., Lieberman, H. A, Kanig, J. L, 1994, Teori dan Praktek Farmasi Industri II, edisi III, diterjemahkan oleh Siti Suyatmi dan Iis Aisyah, UI Press : Jakarta

Parrott, E. L., 1971, Pharmaceutical Technology : Foundamental Pharmaceutic, 3rd ed, Burgers Publishing Company, Minnepolish

Peters D.,1980, Medicated Lozenges, in Lieberman, H. A., Lachman, L., Schwartz, J.B. : pharmaceutical Dosage Form; Tablet, Second Edition, Revised and Expanded, volume 1, Marcel Dekker; New York

Rosanske W. Thomas, Gardon E. Roger. Fonner E. Dale, Anderson R. Neil, and Banker S. Gilber, 1990, Granulation Technology, in Lieberman, H.A., Lachman. L, Schwartz, J.B., : Pharmaceutical dosage Forms : Tablets, Second Edition, Revised and Expanded, Volume II, Mercel Dekker : New York

Sugiyartono, Radjaram A., dan Isadiartuti D., 2003, Pengembangan Formulasi Tablet Hisap Ekstrak Jahe (Zingiber Officinalle Roxb) dengan Bahan Pengikat Etil Selulosa Dan Gelatin B, Majalah Farmasi Airlangga, Surabaya

Syamsuhidayat, S.S., dan Hutapea, J.R., 1991, Inventaris Tumbuhan Obat Indonesia I, Departemen Kesehatan RI, Badan Penelitian & Pengembangan : Jakarta



DOI: https://doi.org/10.22146/tradmedj.7982

Article Metrics

Abstract views : 1236 | views : 3667

Refbacks

  • There are currently no refbacks.




Copyright (c) 2013 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada