HARD CANDY LOZENGES FORMULATION OF LEGUNDI (Vitex trifolia L.) LEAF EXTRACT

https://doi.org/10.22146/tradmedj.8000

Mahfud Alkarim(1), Yosi Bayu Murti(2), T. Nanda Saifullah Sulaiman(3*)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


The purpose of this study is to determine the effect of sugar level variations (sucrose and glucose) to the physical properties and flavor, as well as to determine the level of consumer preferences on hard candy lozenges of Legundi leaf extract. Hard candy lozenges are produced using the fusion method to create three formulas contain combination of sucrose and glucose, which is FI (70%: 30%), FII (50%: 50%), and FIII (30%: 70%). Hard candy lozenges were tested the physical properties include: uniformity of weight, hardness, moisture content test, a soluble and TLC-densitometry and responsive taste test using a questionnaire with scoring assessment by respondents. The test results were analyzed using SPSS 11.0 for windows with a significance level (α) = 0.05. The results showed that the variation of sucrose and glucose levels affect the physical properties of hard candy lozenges of Legundi leaf extract that increases the hardness level, and increase the time to dissolve (p <0.05) but did not affect the water content of the tablet (p> 0.05). The more sucrose is used it increase the hardness of the tablets and dissolve into the longer time. Based on the perceptive sense test results subjectively of hard candy lozenges of Legundi leaf extract, Formula III is the most favored by respondents with sucrose and glucose ratio of 30%: 70%.


Keywords


Legundi, Vitex trifolia L., hard candy lozenges, sukrosa, glukosa



References

Alam, G., Wahyuono, S., Ganjar, I.G., Hakim, L., Timmerman, H. and Verpoorte,R., 2002, Tracheospasmolythic Activity of Viteosin-A and Vitexicarpin Isolated from the Leaves of Vitex trifolia L, Planta Med., (68), 1047-1049

Alam, G., 2005, Isolation and Structure Elucidation of Tracheospasmolytic Compounds from Vitex trifolia L. Leaves, Disertasi, Universitas GadjahMada, Yogyakarta

Alikonis, J,J., 1979, Candy Technology, 120-122, AVI Publishing Company, Inc., Westport Connecticut

Allen, L.V., 2002, The Art, Science, and Technology of Pharmaceutical Compounding, Second Edition, 172-173, 176-177, 184-186, American Pharmaceutical Association, Washington, D.C

Anonim, 2007, Peraturan Menteri Kesehatan RI No.760/ Menkes/Per/IX/1992 tentang daftar obat tradisional yang harus dikembangkan menjadi fitofarmaka, BPOM RI, Jakarta

Armstrong, N.A., 2005, Sucrose in Rowe C.R., Sheskey, P.J., and Owen, S.C.,(Eds)., Handbook of Pharmaceutical Exipients, 5th Edition, 743-747, Pharmaceutical Press, London, UK

Banker, G.S. and Anderson, N,R., 1986, Tablet, in Lachman L., Lieberman, H.A.,Kanig, J.L., (Eds), The Theory and Practice of Industrial Pharmacy, 3rd Edition, 683-703, Lea and Febiger, Philadelphia

Edwards, W.P., 2000, The Science of Sugar Confectionery, 26, 88-89, The Royal Society of Chemistry, Cambridge

Gunawan, D., dan Mulyani, S., 2004, Ilmu Obat Alam (Farmakognosi), Jilid 1, 31-34, Penebar Swadaya, Jakarta

Khankari and Hontz, 1997, Binder and Solvent, in Parikh,M, (Eds.) Handbook of Pharmaceutical Granulation Technology, Volume 8, 66-67, Marcel Dekker, Inc., New York

Lees, R., 1990, General Technical Aspects of Industrial Sugar Confectionery Manufacture, In Jackson, E.B., (Eds)., Sugar Confectionery Manufacture, 140, Blackie and Son Ltd., London

Parrot, E.L., 1971, Pharmaceutical Technology: Fundamental Pharmaceutics,3rd Edition, 82, Burges Publishing Company, Mineapolis.

Robinson, F., 1995, Kandungan Organik Tumbuhan Tingkat Tinggi, diterjemahkan oleh Kosasih Padmawinata, 191-200, Penerbit ITB, Bandung

Suharman dan Mulja, M., 1995, Analisa Instrumental, 238, Airlangga University Press, Surabaya

Zuhra, C.F., 2006, Flavor (Cita Rasa), Karya Ilmiah, Fakultas MIPA Universitas Sumatera Utara, Medan



DOI: https://doi.org/10.22146/tradmedj.8000

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