Optimization of Gelling Agent of Sunflower (Helianthus annuus) Seed Oil Gel and Its Stability and Activity Test In Vitro as Sunscreen

https://doi.org/10.22146/mot.80299

Abdul Karim Zulkarnain(1*), Feela Faridhotu(2), Ifthary Naqsya PR(3)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Excessive ultraviolet (UV) radiation from the sun can harm human skin, such as skin erythema or sunburn, premature aging of the skin, darker skin discoloration, and damage to skin cells. Skin protection, like sunscreen, is needed to prevent the negative effects of UV rays. This study aims to evaluate the optimum formula, the physical properties, and the activity of a sunscreen gel preparation of sunflower seed oil in vitro. The method in this study was optimization with Design Expert version 10 of the carbopol gelling agent and sodium carboxymethyl cellulose. The optimum formula obtained was tested for its physical properties and activity as a sunscreen in vitro with a spectrophotometer.  The results showed that the physical properties of the optimum formula were good, and stable during storage, pH, spreadability, adhesion, and viscosity were close to predictions, and the in vitro SPF test obtained a value of 15.60.


Keywords


Optimization; gel; SPF; sunflower

Full Text:

PDF


References

Anonim, 2014, Farmakope Indonesia, Edisi 5, Departemen Kesehatan Republik Indonesia, Jakarta.

Damogalad, V. Hosea Jaya Edy dan Hamidah Sri Supriadi, 2013, Formulasi Krim Tabir Surya Ekstrak Kulit Nanas (Ananas comosus L Merr) dan Uji In Vitro Nilai Sun Protecting Factor (SPF), Pharmacon Jurnal Ilmiah Farmasi UNSRAT Vol. 2 No. 2, Program Studi Farmasi FMIPA UNSRAT, Manado.

Draelos, Z. D., dan Thaman, L.A., 2006, Cosmetic Formulation of Skin Care Product, Taylor and Francis Group, New York.

Elsner, P., Sivamani, R.K., Jagdeo, J.R., Mailbach, H.I., 2016, Cosmeceuticals and Active Cosmetics, 3rd edition, CRC Press, New York.

Gupta, S.D., 2010, Cosmetic Attributes of Aloe Vera L. Gel, Medicinal and Aromatic Plant Science and Biotechnology.

Juniarti, R., Herdiana Y., 2017, ‘Revier Article: Aktivitas Ekstrak Helianthus annuus L.’, Jurnal Farmaka Universitas padjajaran, Volume 15 No. 2, Jatinagor.

Kulkarni, S. S., (2014) ‘Herbal Plants in Photo Protection and Sun Screening Action: an Overview’, Indo American Journal of Pharmaceutical Research American Journal Of Pharm Research.

Lavi, Novita, 2012. Sunscreen For Travellers, Departement Pharmacy Faculty of Medicine, University of Udayana, Denpasar.

Mollet, H. dan Grubenmann, A., 2001, Formulation Technology, Emulsion, Suspension, Solid Forms, Wiley-Vch, Toronto.

Marchaban, Fudholi, A., Sulaiman, T.N.S., Mufrod, Martin, R., dan Bestari, A.N., 2016, Seri Buku Petunjuk Praktikum Teknologi Farmasi: Teknologi Formulasi Sediaan Cair Semi Padat, Laboratorium Teknologi Farmasi Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta.

Neti.S. (2013). Ensiklopedia dan Tanaman Obat, Rumah Ide, Malang

Rowe, R.C., Sheskey, P.J., Quinn, M.E., 2009, Handbook of Pharmaceutical Excipients¸6th edition, Pharmaceutical Press, British.

Shaath, Nadim. A. 2005. Sunscreens, Third Edition, Taylor & Francis Group, New York, Page 359.

Shovyana, H.H., Zulkarnain, A.K., 2013, Physical Stability and Activity of Cream W/O Etanolic Fruit Extract of Mahkota Dewa (Phaleria macrocarpha (scheff.) Boerl) as A Sunscreen, Traditional Medicine Journal, 18(2).

Sulaiman, T.N.S., Tambunan, S., 2018, ‘Formulasi Gel Minyak tsiri Sereh dengan Basis HPMC dan Karbopol’, Majalah Farmaseutik Vol. 14 No. 2:87-95.

Susanti Y., Purba A.N, Rahmat D., 2019, Nilai Antioksidan dan SPF dari Kombinasi Minyak Biji Wijen (Sesamum indicum L.) dan Minyak Biji Bunga Matahari (Helianthus annuus L.), Majalah Farmaseutik Vol. 16 no. 1: 107 – 110.

Voight, R., 1994, Buku Pengantar Teknologi Farmasi, diterjemahkan oleh Soedani, N., Edisi V, Gadjah Mada University Press, Yogyakarta.



DOI: https://doi.org/10.22146/mot.80299

Article Metrics

Abstract views : 1749 | views : 2253

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2022 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada