MUTAGENIC EFFECT OF ETHANOL EXTRACT OF Jatropha curcas L SEED SOLID WASTE OBTAINED FROM RESIDUAL FUEL VEGETABLE PROCESSING (BIOFUEL)

https://doi.org/10.22146/tradmedj.8131

Retno Wahyuningrum(1*), Komar Ruslan Wirasutisna(2), Elfahmi Elfahmi(3), Marlia Singgih Wibowo(4)

(1) Faculty of Pharmacy, University of Muhammadiyah Purwokerto
(2) School of Pharmacy, Bandung Institute of Technology
(3) School of Pharmacy, Bandung Institute of Technology
(4) School of Pharmacy, Bandung Institute of Technology
(*) Corresponding Author

Abstract


Jatropha curcas seed contains viscous oil that can be used for soap making, cosmetic and as biofuel. It contains phorbol ester that was toxic. Biofuel production of Jatropha curcas seed left seedcake from mechanical press process. For safety evaluation, mutagenicity test was carried out. The seedcake was extracted by maceration method at room temperature with methanol and the mutagenic effect was evaluated by Ames test against Salmonella typhimurium TA 1535 with or without S9 metabolic activator. Methanolic extract of Jatropha curcas seedcake had no mutagenicity effect against S. typhimurium TA 1535. 


Keywords


Jatropha curcas; seedcake; mutagenicity effect



References

Beyioku, A.F., Oyibo, W.A., dan Anuforom, B.C., 1998, Disinfectant/Antiparasitik Activities of J.curcas, East African Med Journal, 75, 508-511

Goel, G., Makkar, H.P.S., Francis, G., dan Becker, K., 2007, Phorbol Esters: Structure, Biological Activity, and Toxicity in Animals, International Journal of Toxicology, 26, 279–288

Igbinosa, O.O., Igbinosa, E.O., dan Aiyegoro, O.A. (2009) : Antimicrobial Activity and Phytochemical Screening of Stembark Extracts from Jatropha curcas (Linn), African Journal of Pharmacy and Pharmacology, 3(2), 58-62

Matsuse, I.T., Lim, Y.A., Hattori, M., Correa, M., dan Gupta, M.P. (1999) : A Search for Antiviral Properties in Panamian Medicinal Plants. The effect on HIV and its Essential Enzymes, Journal of Ethnopharmacology, 64, 15-22

Muanza, D.N., Kim, B.W., Euler, K.L., dan Williams, L. (1994) : Antibacterial and Antifungal Activities of Nine Medicinal Plants from Zaire, International Journal Pharmacognosy, 32 (4), 337-345

Openshaw, K. (2000) : A review of Jatropha curcas: An Oil Plant of Unfulfilled Promise, Biomass and Bioenergy, 19, 1-15

Rug, M dan Ruppel, A. (2000) : Toxic Activities of the Plant Jatropha curcas Against Intermediate Snail Hosts and Larvae of Schistosomes, Tropical Medicine and International Health, 5(6), 423-430

Sadiq, M.F., dan Owais, W.M. (2000) : Mutagenicity of Natrium azidaand Its Metabolite Azidoalanine in Drosophila melanogaster, Mutation Research, 469, 253–257

Wahyuningrum, R. (2010) : Aktivitas Antimikroba Ampas Biji Jarak (Jatropha curcas L) Sisa Pengolahan Bahan Bakar Nabati (Biofuel), Tesis, Institut Teknologi Bandung, Bandung



DOI: https://doi.org/10.22146/tradmedj.8131

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