FORMULATION OF LENGKUAS RHIZOME (Alpinia galanga L.) EXTRACT’S GEL AS ANTIFUNGAL WITH HIDROXY PROPHYL METHYL CELLULOSAE (HPMC) AND CARBOPOL BASE

https://doi.org/10.22146/tradmedj.8218

Wintari Taurina(1*), Mohamad Andrie(2)

(1) Faculty of Medical, Universitas Tanjungpura
(2) Faculty of Medical, Universitas Tanjungpura
(*) Corresponding Author

Abstract


Infection of Malassezia furfur on skin can be caused by bad factor. One of the materials that can be used as an antifungal is Lengkuas rhizome extract (Alpinia galanga L.). This study had purpose to determine the antifungal activity and the effectiveness of gels Lengkuas rhizome extract on pathogenic fungi using maseration method with etanol 96%. Gel making is used HPMC and carbopol base. Testing activity of extract and testing the effectiveness of the gel by disc diffusion method (Kirby-Bauer test). Screening result  showed that the extract contains triterpenoids, flavonoids and essential oil. Based on the test results against Malassezia furfur, antifungal activity of the extract in the gel increased compared to extracts without formulated into a gel. But the activity increasing was not significant based on statistical analysis with one-way ANOVA test obtained a significance of 0.234 (p> 0.05). 


Keywords


gel, lengkuas, antifungal, HPMC, carbopol

Full Text:

pdf


References

Depkes RI, 1979, Farmakope Indonesia, Edisi III, Departemen Kesehatan Republik Indonesia, Jakarta, 21, 143

Depkes RI, 1986, Sediaan Galenik, Departemen Kesehatan Republik Indonesia, Jakarta, 6-7

Gholib, D., 2011, Uji Daya Antifungi Ekstrak Etanol Rimpang Kencur (Kaempferia galanga L.) terhadap Pertumbuhan Jamur Trichopyton verrucosum secara In Vitro, Seminar Nasional Peternakan dan Veteriner, Balai Besar Penelitian Veteriner, Bogor

Handajani, N. S. dan Purwoko, C., 2008, Aktivitas Ekstrak Rimpang Lengkuas (Alpinia galanga) terhadap Pertumbuhan Jamur Aspergillus spp. Penghasil Aflatoksin dan Fusarium moniliforme, Jurnal Biodiversitas, 9 (3): 161-164

Helal, D. A., El-Rhman, D., Abd, A. H., Sally, A., dan El-Nabarawi, M. A., 2012, Formulation and Evaluation of Fluconazole Topical Gel, International Journal of Pharmacy and Pharmaceutical Sciences, 4, Suppl. 5

ICMR, 2009, Detection of Microbial in Common Gram Negative and Gram Positive Bacteria Encountered in Infection Desease, ICMR Bulletin, 39, 1-3

Setyarini, P. S. dan Krisnansari, D., 2011, Perbandingan Efek Antifungi Ekstrak Lengkuas (Alpinia galanga Linn) dengan Ketokonazol pada Isolat Malassezia furfur, Journal Mandala of Health, 5 (2)

Soebagio, B., 2007, Pembuatan Gel Dengan Aqupec HV-505 dari Ekstrak Umbi Bawang Merah (Allium cepa, L.) Sebagai Antioksidan, Jurnal Seminar Penelitian, Fakultas Farmasi Universitas Padjadjaran

Suardi, M., Anita, M., dan Armenia, 2004, Formulasi Dan Uji Klinik Gel Anti Jerawat Benzoil Peroksida-HPMC, Jurnal Penelitian, Fakultas Farmasi FMIPA UNAND, Padang

Voigt, R., 1995, Buku Pelajaran Teknologi Farmasi, Gadjah Mada University Press, Yogyakarta

Wathoni, N., Taofik., dan Riny Y.H., 2009, Formulasi Gel Antioksidan Ekstrak Rimpang Lengkuas (Alpinia galanga L.Willd) dengan Menggunakan Basis Aqupec 505 HV, Jurnal Farmaka, 7 (1)

Windholz, M., Budavari, S., Blumetti, R.F., dan Ottertein, 1983, Encyclopedia of Chemicals, Drugs, and Biologicals, Merck & Co. USA.

Yuharmen, Y., Eryanti, Y., dan Nurbalatif, 2002, Uji Aktivitas Antimikrobia Minyak Atsiri dan Ekstrak Metanol Lengkuas (Alpinia galanga), Jurnal Nature Indonesia, 4 (2): 178-183



DOI: https://doi.org/10.22146/tradmedj.8218

Article Metrics

Abstract views : 1766 | views : 2807

Refbacks

  • There are currently no refbacks.




Copyright (c) 2015 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

©Majalah Obat Tradisional (Trad.Med.J) 
Faculty of Pharmacy
Universitas Gadjah Mada