HEPATOPROTECTIVE AND NEPHROPROTECTIVE EFFECTS OF AVOCADO SEEDS AGAINST CARBON TETRACHLORIDE IN RATS

https://doi.org/10.22146/tradmedj.8230

Phebe Hendra(1*), Gidion Krisnadi(2), Ni Luh Putu Dian Perwita(3), Ike Kumalasari(4), Yuditha Anggarhani Quraisyin(5)

(1) Faculty of Pharmacy, Universitas Sanata Dharma
(2) Faculty of Pharmacy, Universitas Sanata Dharma
(3) Faculty of Pharmacy, Universitas Sanata Dharma
(4) Faculty of Pharmacy, Universitas Sanata Dharma
(5) Faculty of Pharmacy, Universitas Sanata Dharma
(*) Corresponding Author

Abstract


The aim of this research to investigate the hepatoprotective and nephroprotecitve effects of Avocado seeds against carbon tetrachloride in rats. The rats was treated with the infusion and decoction of avocado seeds at doses 360.7, 642.1, 1142,9 mg/kg per oral once in a day for 6 days and carbon tetrachloride (2mL/kg) was given on the 7th day. Blood sample from all groups was obtained by sinus orbitalis after 24 hours application for the serum transaminase and creatinine. The increasing of serum transaminase and creatinine in carbon tetrachloride-treated rats, were significantly decreased (p<0.05) with both pretreatment of infusion and decoction of avocado seeds. Based on the research, it can be concluded that infusion and decoction of avocado seeds have a potent protective action upon carbon tetrachloride-induced hepatic and renal damage in rats.

Keywords


avocado, protective, infusion, carbon tetrachloride

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References

Arukwe, U., Amadi, B.A., Duru, M.K.C., Agomuo, E.N., Adindu, E.A., Odika, P.C., 2012, Chemical Composition of Persea americana leaf, fruit and seed. IJJRAS 11: 346-348

Bashandy, S.A., AlWasel, S.H., 2011, Carbon tetrachloride-induced hepatotoxicity and nephrotoxity in rats: protective role of vitamin C. J. Pharmacol. Toxicol., 6(3): 283-292

Febrianti, C.H., 2012, Efek Hepatoprotektif Jangka Waktu Enam Jam Ekstrak Etanol Daun Macaranga tanarius L. Terhadap Aktivitas ALT-AST Pada Tikus Jantan Terinduksi Karbon Tetraklorida, Skripsi, Universitas Sanata Dharma, Yogyakarta

Hodgson, E., 2010, A Textbook of Modern Toxicology, 4th Ed., John Wiley & Sons,Inc., New Jersey: 168, 277-289

Janakat, S., Al-Merie, H., 2002, Optimization of the dose and route of injection, and characterization of the time course of carbon tetrachloride-induced hepatotoxicity in the rat, J. Pharm. Tox. Methods, 48: 41-44

Junqueira, L.E., Carneiro, J., Kelley, R.O., 2007, Basic Histology, 11st Ed. Mc Graw-Hill, Boston: 373-390

Khan, M.R., Rizvi, W., Shaheen, S., 2009, Carbon tetrachloride-induced nephrotoxicity in rats: Protective role of Digera muricata, J. Ethnopharmacology, 122: 91-99

Konsinska, A., Karamec, M., Estrella, I., Hernandez, T., Bartolome, B., Dykes, G.A., 2012, Phenolic compound profiles and antioxidant capacity of Persea americana Mill. Peels and Seeds of two varieties, J. of Agric. Food Chem., 60: 4613-4619

Malangngi, L., Meiske, S., Jessy, J., 2012, Penentuan Kandungan Tanin dan Uji Aktivitas Antioksidan Ekstrak Biji Buah Alpukat (Persea americana Mill). Jurnal MIPA UNSRAT, 1 (1): 5-10

Manna, P., Sinha, M., Sil, P.C., 2006, Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders, BMC Complementary Alternative Med., 6: 33-33

Nirmala, M., Girija, K., Lakshman, K., Divya, T., 2012, Hepatoprotective activity of Musa paradisiacal on experimental animal models, Asian Pasific Journal of Tropical Biomedicine: 11-15

Nurachman, E., Angriani, R., 2011, Dasar-dasar Anatomi dan Fisiologi, Salemba Medika, Jakarta: 192-196

Panjaitan, R.G.P., Handharyani, E., Chairul, Masriani, Zakiah, Z., Manalu, W., 2007, Pengaruh Pemberian Karbon Tetraklorida terhadap Fungsi Hati dan Ginjal Tikus, Makara Kesehatan, 11 (1): 11-16

Sacher, R.A., McPherson, R.A., 2004, Tinjauan Klinis Hasil Pemeriksaan Laboratorium, EGC, Jakarta: 291-293

Seyoum, A., Asres, K., El-Ficky, F.K., 2006, Structure-radical scavenging activity relationships of flavonoids, Phytochemistry, 67: 2058-2070

Timbrell, J.A., 2008, Principles of Biochemical Toxicology, 4th Ed., Informa Healthcare, New York: 308-311

Wibowo, D.J., Paryana W., 2009, Anatomi Tubuh Manusia. Graha Ilmu, Bandung: 347-352

Zimmerman, H.J., 1999, Hepatotoxicity, 2nd Ed., Lippincott Williams and Wilkins, Philadephia: 195-210



DOI: https://doi.org/10.22146/tradmedj.8230

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