Geographical Distribution, Chemical Constituents, and Activity Profile of Magnolia

Purabi Saha(1), Supriyo Saha(2*), Amit Semwal(3), Prinsa Prinsa(4), Tarun Parashar(5), Vikash Jakhmola(6)

(1) Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand
(2) Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand, INDIA.
(3) College of Pharmacy, Shivalik Campus, Dehradun, Uttarakhand
(4) Siddhartha Institute of Pharmacy, Sahastradhara Road Near IT-Park Dehradun 248001
(5) Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand
(6) Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand
(*) Corresponding Author


Many Asian countries use the bark of the Magnolia for medicinal purposes. Magnolia has many medical uses, including regulating GI motility, treating cough and asthma, preventing cardiovascular disease, and treating mental illness and brain disorders. To date, 118 magnolia species have been discovered. However, the International Union for Conservation of Nature has designated 231 species as vulnerable and critically endangered. Magnolia leaves yielded 20 isolated chemicals, including 16 lignans with 6 distinct structural types, such as honokiol, veraguensin, sitosterol, and magliflonenone. Magnolia species show pharmacological activities like Neuroprotective, anti-cancer, Anti-microbial, Antiplatelets, Anti-asthmatic, Gastrointestinal, and Hormone regulation. Magnolia bark extracts such as honokiol 2',6-di-(5-propenyl)-1,1'-biphenyl-2,2'-diol, have been demonstrated to benefit health. In recent in vitro and preclinical research, honokiol was found to have anti-inflammatory, anti-angiogenic, anti-oxidative, and anti-cancer activities. Honokiol and magnolol prevented the thromboxane B2 synthesis in response to thrombin, arachidonic acid, and collagen. So, soon, if we cultivate and save the endangered magnolia species through biotechnological means, it will be a boon for mankind.


Magnolia; Geographical distribution; Pharmacological; Phytochemical; Therapeutic activity

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Arora, S., Singh, S., Piazza, G.A., Contreras, C.M., Panyam, J., & Singh, A.P., 2012, Honokiol: a novel natural agent for cancer prevention and therapy. Curr. Mol. Med. 12(10), 1244-52. 10.2174/156652412803833508

Arredondo-Valdés, R., Hernández-Castillo, F.D., Rocandio-Rodríguez, M., Anguiano-Cabello, J.C., Rosas-Mejía, M., Vanoye-Eligio, V., Ordaz-Silva, S., López, S., Carrazco-Peña, L.D., & Chacón-Hernández, J.C., 2021, In vitro antibacterial activity of Moringa oleifera ethanolic extract against tomato phytopathogenic bacteria. Phyton. 90(3), 895. 10.32604/phyton.2021.014301

Azlan, U.K., Mediani, A., Rohani, E.R., Tong, X., Han, R., Misnan, N.M., Jam, F.A., Bunawan, H., Sarian, M.N., & Hamezah, H.S., 2022, A comprehensive review with updated future perspectives on the ethnomedicinal and pharmacological aspects of Moringa oleifera. Molecules. 7(18), 5765.

Bekhit, A.E., Giteru, S.G., Holman, B.W., & Hopkins, D.L., 2021, Total volatile basic nitrogen and trimethylamine in muscle foods: Potential formation pathways and effects on human health. Comprehensive. Review. Food. Science. Food. Safety. 20(4), 3620-66.

Bhatt, S.P., Chanda, S., Bilandi, A., Jakhmola, V., Tiwari, R.K., 2023, Phytochemical, ethnomedicinal and pharmacological overview of Ajuga bracteosa Wall. Ex. Benth : An endengered medicinal plant of Uttrakhand, INDIA. Euro Chem Bull 12(6), 2881-2990.

Chacón-Hernández, J., Arredondo-Valdés, R., Reyes-Zepeda, F., Hernández-Castillo, F.D., Anguiano-Cabello J.C., Heinz-Castro, R.T., & Mora-Ravelo, S.G., 2020, In vitro antibacterial activity of Magnolia tamaulipana against tomato phytopathogenic bacteria. Plant. Protection. Sci. 56(4), 268-74. 10.17221/13/2020-PPS

Chen, H.H., Chang, P.C., Chen, C., Chan, M.H., 2018, Protective and therapeutic activity of honokiol in reversing motor deficits and neuronal degeneration in the mouse model of Parkinson's disease. Pharmacol Rep 70(4), 668-676.

Cui, S.M., Liang, H.Y., Li, T., He, K.K., Zheng, Y.M., Tang, M., Ke, C.R., & Song, L.Y., 2021, Interaction of magnolia bark extracts with Staphylococcus aureus DNA and evaluation of the stability of their antibacterial activities. Archives. Microbiology. 203(8), 5215-24. 10.1007/s00203-021-02501-5

Dũng, N.X., Thâm, N.T., Van Khiên, P., Quang, N.T., Lê, H.T., & Leclercq, P.A., 1997, Characterization of the oils from various

parts of Talauma gioi Aug. Chev.(Magnoliaceae) from Vietnam. J. Essential. Oil. Research. 9(1), 119-21.

Han, C.Y., & Long, C.L., 2010, Dormancy, germination and storage of Magnolia ingrata seeds. Seed. Science. Technology. 38(1), 252-6.

Hirsch, G.E.,Viecili, P.R.N., de Almeida, A.S., Nascimento, S., Porto, F.G., Otero, J., Schmidt, A., da Silva, B., Parisi, M.M., & Klafke, J.Z., 2017, Natural Products with Antiplatelet Action. Curr. Pharm. Des. 23(8), 1228-1246.

Ho, K.Y., Tsai, C.C., Chen, C.P., Huang, J.S., & Lin, C.C., 2021, Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis. Phytotherapy Res. 15(2), 139-41. 10.1002/ptr.736

Hu, Y., Qiao, J., Zhang X., & Ge, C., 2011, Antimicrobial activity of Magnolia officinalis extracts in vitro and its effects on the preservation of chilled mutton. J. Food. Biochemistry. 35(2), 425-41.

Huang, Q., Lele, H., Rong L., & Ling, L., 2019, Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice. The Korean. J. Physiology. Pharmacology. 23(4), 251-261. 10.4196/kjpp.2019.23.4.251

Jacobo-Salcedo, M.D., Gonzalez-Espindola, L.A., Alonso-Castro, A.J., Gonzalez-Martinez, M.D., Domínguez, F., & Garcia-Carranca, A., 2011, Antimicrobial activity and cytotoxic effects of Magnolia dealbata and its active compounds. Natural. Product. Communications. 6(8), 1121-1124.1934578X1100600818.

Kim, H.J., Han, T., Kim, Y.T., So, I., & Kim, B.J., 2017, Magnolia officinalis bark extract induces depolarization of pacemaker potentials through M2 and M3 muscarinic receptors in cultured murine small intestine interstitial cells of cajal. Cellular. Physiology. Biochemistry. 43(5), 1790-802.

Kinho, J., Arini, D.I.D., Abdulah, L., Susanti, R., Irawan, A., Yulianti, M., Subarudi, S., Imanuddin, R., Wardani, M., Denny, D., Kalima, T., Hardjana, A.K., Susilo, A., Heriansyah, I., & Tampang, A., 2022, Habitat Characteristics of Magnolia Based on Spatial Analysis: Landscape Protection to Conserve Endemic and Endangered Magnolia sulawesiana Brambach, Noot., and Culmsee. Forests 13(5), 802.

Liu, H., Xu, Q., He, P., Santiago, L.S., Yang, K., & Ye, Q., 2015, Strong phylogenetic signals and phylogenetic niche conservatism in ecophysiological traits across divergent lineages of Magnoliaceae. Scientific. Reports. 5(1), 1-2. 10.1038/srep12246

Mali, R.G., & Dhake, A.S., 2011, A review on herbal antiasthmatics. Orient Pharm Exp Med.11, 77-90.

Mohd Nor, N.H., Othman, F., Mohd Tohit, E.R., & Md Noor, S., 2016,. Medicinal herbals with antiplatelet properties benefit in coronary atherothrombotic diseases. Thrombosis. 8(2), 719 741. 10.1155/2016/5952910

Ni, Y.Q., Lin, X., Zhan, J.K., & Liu, Y.S., 2020, Roles and functions of exosomal non-coding RNAs in vascular aging. Aging. Disease. 11(1), 164. 10.14336/AD.2019.0402

Ong, C.P., Lee, W.L., Tang, Y.Q., & Yap, W.H., 2020, Honokiol: A Review of Its Anticancer Potential and Mechanisms. Cancer. 12, 48.

Park, E.S., Lim, Y., Lee, S.H., Kwon, B.M., Yoo, H.S., Hong, J.T., & Yun, Y.P., 2011, Antiplatelet activity of obovatol, a biphenolic component of Magnolia Obovata, in rat arterial thrombosis and rabbit platelet aggregation. J. Atherosclerosis. Thrombosis. 18(8), 659-69. 10.5551/jat.7427

Poivre, M., & Pierre, D., 2017, Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents. J. Zhejiang. University. Science B. 18(3), 194-214.

Ramyashree. C., & Hemalatha, K., 2020, Ethnomedicinal profile on magnolia species (Magnoliaceae): A review. Int. J. Herbal. Medicine. 8(3), 39-46.

Reyes-Zepeda, F., Heinz-Castro, R.T., Olazaran-Santibañez, F.E., Ordaz-Silva, S., Pedro-Méndez, J.G., & Chacón-Hernández, J.C., 2022, Evaluation of Ethanolic Powdered Extract of Magnolia tamaulipana Vazquez against Oligonychus punicae Hirst (Trombidiformes: Tetranychidae). Plants. 11(13), 1711. 10.3390/plants11131711

Shih, C.Y., & Chou, T.C., 2012, The antiplatelet activity of magnolol is mediated by PPAR-β/γ. Biochemical. Pharmacology. 84(6), 793-803. 10.1016/j.bcp.2012.06.022

Singh, T., Gupta, N.A., Xu, S., Prasad, R., Velu, S.E., & Katiyar, S.K., 2015, Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor. Oncotarget. 6(25), 21268-82.

Simon, S., Joseph, J., & George, D., 2022, Optimization of extraction parameters of bioactive components from Moringa oleifera leaves using Taguchi method. Biomass. Conversion. Biorefinery. 1(4), 28-45. 10.1007/s13399-021-02276-1

Song, C., & Liu, H., 2019, Habitat differentiation and conservation gap of Magnolia biondii, M. denudata, and M. sprengeri in China. Peer. J. 12(6), e6126.

Szałabska-Rąpała, K., Borymska, W., & Kaczmarczyk-Sedlak, I., 2021, Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities-A Review. International. J. Molecular. Sciences. 22(18), 10050.

Veltjen, E., Testé, E., Bejerano, A.P., Asselman, P., Rodríguez, M.H., Torres, L.R., Chatrou, L.W., Goetghebeur, P., Larridon, I., & Samain, M.S., 2022, The evolutionary history of the Caribbean magnolias (Magnoliaceae): Testing species delimitations and biogeographical hypotheses using molecular data. Molecular. Phylogenetics. Evolution. 167, 107359.

Wang, B., Ma, Y., Chen, G., Li, C., Dao, Z., & Sun, W., 2016, Rescuing Magnolia sinica (Magnoliaceae), a critically endangered species endemic to Yunnan, China. Oryx. 50(3), 446-9.

Wang, X., Fu, S., Zhang, C., Nie, X., Liao, W., Zhao, M., & Liu, F., 2021, Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats. Biomed. Res. Int. 6688414.

Wang, X., Liu, Q., Fu, Y., Ding, R.B., Qi, X., Zhou, X., Sun, Z., & Bao, J., 2022, Magnolol. Potential Anticancer Agent: A Proposed Mechanistic Insight. Molecules. 27, 6441.

Wang, Y.B., Liu, B.B., Nie, Z.L., Chen, H.F., Chen, F.J., Figlar, R.B., & Wen, J., 2020, Major clades and a revised classification of Magnolia and Magnoliaceae based on whole plastid genome sequences via genome skimming. J. Systematics. Evolution. 58(5), 673-95.

Wei, Q., Yang, M., Deng, R., & Liu, S., 2023, Analysis of chemical components in two tree species of magnoliaceae, Magnolia sumatrana var. glauca (Blume) Figlar & Noot and Magnolia hypolampra (Dandy) Figlar. Natural. Product. Research. 37(2), 328-332.

Xie, Z., Zhao, J., Wang, H., Jiang, Y., Yang, Q., Fu, Y., Zeng, H., Hölscher, C., Xu, J., & Zhang, Z., 2020, Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ. Biomedicine. Pharmacotherapy. 124, 109886.

Zhang, Q., Cheng, G., Pan, J., Zielonka, J., Xiong, D., Myers, C.R., Feng, L., Shin, S.S., Kim, Y.H., Bui, D., Hu, M., Bennett, B., Schmainda, K., Wang, Y., Kalyanaraman, B., & You, M., 2020, Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I. Cell. Commun. Signal. 18(1), 58.

Zhu, S., Liu, F., Zhang, R., Xiong, Z., Zhang, Q., Hao, L., & Chen, S., 2022, Neuroprotective Potency of Neolignans in Magnolia officinalis Cortex Against Brain Disorders. Front. Pharmacol. (13), 1-12. 10.3389/fphar.2022.857449


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